MR1 blockade drives differential impact on integrative signatures based on circuits of circulating immune cells and soluble mediators in visceral leishmaniasis

Autor: Luana Oliveira Borges-Fernandes, Marcela de Lima Moreira, Victória Hellena Silva Pereira, Marcelo Antônio Pascoal-Xavier, Ágata Lopes Ribeiro, Ismael Artur da Costa-Rocha, Ludmila Rosa Lopes, Guilherme Telles Cristo Moreira, Márcio Sobreira da Silva Araújo, Andréa Teixeira-Carvalho, Joaquim Pedro Brito-de-Sousa, Andrea Lucchesi de Carvalho, Maria Vitória Assumpção Mourão, Flávia Alves Campos, Marineide Borges, Mariângela Carneiro, Moriya Tsuji, Olindo Assis Martins-Filho, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhães

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionVisceral leishmaniasis (VL) is an important tropical and neglected disease and represents a serious global health problem. The initial interaction between the phagocytes and the parasite is crucial to determine the pathogen’s capacity t

Externí odkaz: https://doaj.org/article/707e52ddb14a4e9ab0c70f6f7c86a106

Anti-Leishmania activity of mucosal-associated invariant T-cells

Autor: Maria Vitória Assumpção Mourão, Marcela de Lima Moreira, Marineide Borges, Malcolm J. McConville, Vanessa Peruhype-Magalhães, Sidonia B G Eckle, Flávia Alves Campos, Marcelo Antônio Pascoal-Xavier, Andrea Lucchesi de Carvalho, Mariângela Carneiro, Zhenjun Chen, Olindo Assis Martins-Filho, Victória Hellena Silva Pereira, Andréa Teixeira-Carvalho, James McCluskey, Moriya Tsuji, Ágata Lopes-Ribeiro, Jordana Grazziela Coelho-dos-Reis, Troi J. Pediongco, Luana Oliveira Borges Fernandes, Eleanor C Saunders, Márcio da Silva Araújo

Mucosal-associated invariant T (MAIT)-cells are restricted by MR1 and are known to contribute to protection from bacterial and viral infections. Here we show that MAIT-cells also play an important role in protection from visceral leishmaniasis-VL, ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad156f4744ef4acbd26ecdeeaee5c28a
https://doi.org/10.21203/rs.3.rs-612599/v1

Effectiveness, safety, and immunogenicity of half dose ChAdOx1 nCoV-19 COVID-19 Vaccine: Viana project

Autor: Valéria Valim, Olindo Assis Martins-Filho, Maria da Penha Gomes Gouvea, Luiz Antônio Bastos Camacho, Daniel Antunes Maciel Villela, Sheila Maria Barbosa de Lima, Adriana Souza Azevedo, Lauro Ferreira Pinto Neto, Carla Magda Allan Santos Domingues, Nésio Fernandes de Medeiros Junior, Isac Ribeiro Moulaz, Laiza Hombre Dias, Samira Tatiyama Miyamoto, Andréa Teixeira-Carvalho, José Geraldo Mill, Half Dose ChAdOx Study Group, Thayná Martins Gouveia, Beatriz Paoli Thompson, Karen Evelin Monlevade Lança, Gabriela Curto Cristianes Lacerda, João Pedro Gonçalves Lenzi, Sabrina de Souza Ramos, Felipe de Castro Pimentel, Ludimila Forechi, Thaís Ruchdeschel, João Pedro Moraes Miossi, Matheus Leite Rassele, Gabriel Smith Sobral Vieira, Laís Pasti, Allan Gonçalves Henriques, Maria Eduarda Morais Hibner Amaral, Alessandro Demoner Ramos, Heitor Filipe Surlo, Laura Gonçalves Rodrigues Aguiar, Luiza Lorenzoni Grillo, Matheus Pereira, Ramon Borge Rizzi, Sara Monteiro Muniz, Hully Cantão dos Santos, Thais Luma de Oliveira Roza, Adriana Santos Silva, Lunara Baptista Ferreira, Karina Lallemand, Ketty Lysie Libardi Lira Machado, Tania Queiroz Reuter Motta, Jaquelini Jubini, Carla Cristina Moraes de Mattos, Maria Angélica Calegário Vieira, Danielle Grillo Pacheco Lyra, Cristiano Soares da Silva, Rodrigo Ribeiro Rodrigues, Luís Carlos Reblin, Orlei Cardoso, Lely Stella Guzmán Barrera, Jhader Pércio, Ismael Artur da Costa Rocha, Roberta Oliveira Prado, Agnes Antônia Sampaio Pereira, Vitor Hugo Simões Miranda, Gláucia Diniz Alessio, Fernanda Fortes de Araújo, Elaine Speziali, Christiane Costa Pereira, Clarice Carvalho Alves, Kétyllen Reis Andrade de Carvalho, Anna Carolina Cançado Figueiredo, Liliane Martins dos Santos, Cristiana Couto Garcia, Nani Oliveira Carvalho, Laise Rodrigues Reis, Tâmilla Mayane Alves Fidelis dos Santos, Joaquim Pedro Brito-de-Souza, Camila Medeiros Costa, Isabela Natália Pascoal Campos do Vale, Priscilla Miranda Henriques, Poliane Silva Maciel, Thais Abdala Torres, Nathália Werneck Cézar de Oliveira, Gabriela de Oliveira, Luana Oliveira Borges Fernandes, Andreza Parreiras Gonçalves, Jesuanne Carla Silva Andrade, Ladson Lúcio Viana da Silva, Armanda Moreira Mattoso Barbosa, Maria Beatriz Martins Araújo, Bruna Luiza Fonte Boa Rocha, Lis Ribeiro do Valle Antonelli, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhães, Waleska Dias Schwarcz, Nathalia dos Santos Alves, Ingrid Siciliano Horbach, Ariane Faria de Souza, Brenda de Moura Dias, Bruno Pimenta Setatino, Caio Bidueira Denani

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Fractional dose is an important strategy to increase access to vaccines. This study evaluated the effectiveness, safety, and immunogenicity of half dose of ChAdOx1 nCoV-19 vaccine. A non-inferiority non-randomized controlled trial compared a half dos

Externí odkaz: https://doaj.org/article/0906b38d59ab4e75add7bcfe17d13124