Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Luan Wen"'
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103436- (2024)
Y chromosome deletion and karyotype abnormalities are commonly associated with congenital non-obstructive azoospermia, impairing spermatogenesis. Specifically, the deletion of the Y chromosome Azoospermia factor a (AZFa) has been identified in infert
Externí odkaz:
https://doaj.org/article/937a5613b1d045388690e6f99dc4b515
Publikováno v:
Molecules, Vol 29, Iss 16, p 3886 (2024)
Artemisinin is a natural sesquiterpene lactone obtained from the traditional Chinese medicinal herb Artemisia annua L. (qinghao). Artemisinin and its derivatives share an unusual endoperoxide bridge and are extensively used for malaria treatment worl
Externí odkaz:
https://doaj.org/article/d07eb98d3cf04d66906117bed1d2aaf1
Autor:
Li-Kuang Tsai, Min Peng, Chia-Chun Chang, Luan Wen, Lin Liu, Xiubin Liang, Y. Eugene Chen, Jie Xu, Li-Ying Sung
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background In eukaryotic cells, DNA double strand breaks (DSB) are primarily repaired by canonical non-homologous end joining (c-NHEJ), homologous recombination (HR) and alternative NHEJ (alt-NHEJ). Zinc finger and SCAN domain containing 4 (
Externí odkaz:
https://doaj.org/article/7dffff95d442413cad8b10bee359437b
Publikováno v:
Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Four polysaccharides (MCPa, MCPb, MCPc, MCPd) were obtained from Lepidium meyenii Walp. Their structures were characterized by chemical and instrumental methods including total sugar, uronic acid and protein content determination, UV, IR and
Externí odkaz:
https://doaj.org/article/c3ee183023c34dac9666e5344a52fc0e
Publikováno v:
Synthetic and Systems Biotechnology, Vol 6, Iss 3, Pp 153-162 (2021)
Ubiquitously distributed microorganisms are natural decomposers of environmental pollutants. However, because of continuous generation of novel recalcitrant pollutants due to human activities, it is difficult, if not impossible, for microbes to acqui
Externí odkaz:
https://doaj.org/article/f77bdb3e8fb2451fa990c40380cd0714
Autor:
Linyuan Ma, Jinxue Ruan, Jun Song, Luan Wen, Dongshan Yang, Jiangyang Zhao, Xiaofeng Xia, Y. Eugene Chen, Jifeng Zhang, Jie Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Cas9 fused to DNA damage repair proteins can improve rates of gene knock-in but the chimeric protein is often large. Here the authors fuse Cas9 to a minimal Brex27 motif from BRCA2 consisting of thirty-six amino acids to enhance the efficacy and safe
Externí odkaz:
https://doaj.org/article/58d62b4781c84e8aa9e7b4d0d8b4512d
Autor:
Kemao Xiu, Laura Saunders, Luan Wen, Jinxue Ruan, Ruonan Dong, Jun Song, Dongshan Yang, Jifeng Zhang, Jie Xu, Y. Eugene Chen, Peter X. Ma
Publikováno v:
Cells, Vol 12, Iss 1, p 156 (2022)
Gene editing nucleases such as CRISPR/Cas9 have enabled efficient and precise gene editing in vitro and hold promise of eventually achieving in vivo gene editing based therapy. However, a major challenge for their use is the lack of a safe and effect
Externí odkaz:
https://doaj.org/article/93602edda32c46029d7ed99e5661f88a
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Thyroid hormone (T3) plays several key roles in development of the nervous system in vertebrates, controlling diverse processes such as neurogenesis, cell migration, apoptosis, differentiation, and maturation. In anuran amphibians, the hormone exerts
Externí odkaz:
https://doaj.org/article/52f366d318a74fc19dc93202fdb9aa59
Autor:
Luan Wen, Changzhi Zhao, Jun Song, Linyuan Ma, Jinxue Ruan, Xiaofeng Xia, Y. Eugene Chen, Jifeng Zhang, Peter X. Ma, Jie Xu
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 653 (2020)
Mammalian telomere lengths are primarily regulated by telomerase, a ribonucleoprotein consisting of a reverse transcriptase (TERT) and an RNA subunit (TERC). TERC is constitutively expressed in all cells, whereas TERT expression is temporally and spa
Externí odkaz:
https://doaj.org/article/91fd69f7a2844fa58c07f95ddaf57790
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38939 (2012)
GOLPH2 is a highly conserved protein. It is upregulated in a number of tumors and is being considered as an emerging biomarker for related diseases. However, the function of GOLPH2 remains unknown. The Xenopus model is used to study the function of h
Externí odkaz:
https://doaj.org/article/dffbf4e359364f6e9d1a0ba94a43f886