Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lu-Bin Lan"'
Autor:
Erin G. Schuetz, Richard B. Kim, John D. Schuetz, Thomas A. Kocarek, Stephen C. Strom, Kazuto Yasuda, Lu-Bin Lan
Publikováno v:
Molecular Pharmacology. 62:439-445
We report the development of a rapid real-time assay that measures the transcription of luciferase reporter genes in transduced mouse hepatic cells in vivo. Luciferase activity is noninvasively measured by whole-body optical imaging within hours of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843bf985b970043b675bbd05105eb8dc
https://doi.org/10.1124/mol.62.3.439
https://doi.org/10.1124/mol.62.3.439
Autor:
Mark A. Winter, James H. Wikel, Lu-Bin Lan, John D. Schuetz, Sean Ekins, Kazuto Yasuda, Anne H. Dantzig, Robert L. Shepard, Brenda F. Leake, Erin G. Schuetz, Steven A. Wrighton, Richard B. Kim
Publikováno v:
Molecular Pharmacology. 61:964-973
P-glycoprotein (P-gp) is an efflux transporter involved in limiting the oral bioavailability and tissue penetration of a variety of structurally divergent molecules. A better understanding of the structural requirements of modulators of P-gp function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8af447e299be29454bd336e72bc016
https://doi.org/10.1124/mol.61.5.964
https://doi.org/10.1124/mol.61.5.964
Autor:
James H. Wikel, Erin G. Schuetz, Robert L. Shepard, Anne H. Dantzig, Brenda F. Leake, Richard B. Kim, Lu-Bin Lan, Mark A. Winter, Steven A. Wrighton, Kazuto Yasuda, Sean Ekins, John D. Schuetz
Publikováno v:
Molecular Pharmacology. 61:974-981
Using in vitro data, we previously built Catalyst 3-dimensional quantitative structure activity relationship (3D-QSAR) models that qualitatively rank and predict IC(50) values for P-glycoprotein (P-gp) inhibitors. These models were derived and tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5e3662b48b7b989b3f0dd59f2a785b
https://doi.org/10.1124/mol.61.5.974
https://doi.org/10.1124/mol.61.5.974
Publikováno v:
Molecular Pharmacology. 58:863-869
We determined whether the drug efflux protein P-glycoprotein (Pgp) could influence the extent of CYP3A-mediated metabolism of erythromycin, a widely used model substrate for CYP3A. We compared CYP3A metabolism of erythromycin (a Pgp substrate) using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe826df11110d657fc5f348074278433
https://doi.org/10.1124/mol.58.4.863
https://doi.org/10.1124/mol.58.4.863
Publikováno v:
Anti-Cancer Drugs. 7:60-69
Vinblastine at doses ranging from 0.2 to 6 mg/kg body weight was administered i.p. to mice in the absence or presence of the drugs PSC 833, cyclosporin A, mefloquine, quinidine and dipyridamole, all compounds that modulate the multidrug resistance pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bc6107597fc9b1cd1898d56e5e9af3
https://doi.org/10.1097/00001813-199601000-00007
https://doi.org/10.1097/00001813-199601000-00007
Autor:
Kristina K. Wolf, Jacqueline F. Sinclair, Elizabeth H. Jeffery, Juliana G. Szakacs, Lu-Bin Lan, Steven A. Wrighton, Peter R. Sinclair, David J. Greenblatt, Brooke W. Walton-Strong, Su X. Duan, Lisa L. von Moltke, Jane A. Hunt, Kazuto Yasuda, Sheryl G. Wood, Ronald M. Evans, Michael H. Court, Qin Hao, Erin G. Schuetz
Publikováno v:
Drug Metabolism and Disposition.
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and rats with inducers of CYP3A increases acetaminophen (APAP) hepatotoxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::254702920382d5c14ce9cf14458de2f8
https://doi.org/10.1124/dmd.105.005256
https://doi.org/10.1124/dmd.105.005256
Autor:
Philippe Gambert, Mahfoud Assem, David Masson, Laurent Lagrost, Erin G. Schuetz, John D. Schuetz, Anne Athias, Cynthia Brimer-Cline, Lu-Bin Lan
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 25(10)
Objective— Modification of lipoprotein metabolism by bile acids has been mainly explained by activation of the farnesyl X receptor (FXR). The aim of the present study was to determine the relative contribution of the pregnane X receptor (PXR), anot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6229a6da5f566e64f43db4233a33d5
https://pubmed.ncbi.nlm.nih.gov/16199756
https://pubmed.ncbi.nlm.nih.gov/16199756
Autor:
Erin G. Schuetz, Wooin Lee, Rommel G. Tirona, Brenda F. Leake, Cynthia Cline, Yusuke Inoue, Richard B. Kim, Stephen A. Duncan, Fereshteh Parviz, Frank J. Gonzalez, Vishal Lamba, Lu-Bin Lan
Publikováno v:
Nature medicine. 9(2)
The drug metabolizing enzyme cytochrome P450 3A4 (CYP3A4) is thought to be involved in the metabolism of nearly 50% of all the drugs currently prescribed. Alteration in the activity or expression of this enzyme seems to be a key predictor of drug res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc2930ab331fd6b56ddee9a09df6244
https://pubmed.ncbi.nlm.nih.gov/12514743
https://pubmed.ncbi.nlm.nih.gov/12514743
Autor:
Dominique Sanglard, Lu-Bin Lan, Kazuto Yasuda, Erin G. Schuetz, John D. Schuetz, Katryn N. Furuya
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 303(1)
Many clinically important drug interactions occur due to inhibition of human liver cytochrome P450 3A (CYP3A) metabolism. The drug efflux pump P-glycoprotein (Pgp) can be an additional locus contributing to these drug interactions because there is ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7995860d13c426e7cad752fefe24561c
https://pubmed.ncbi.nlm.nih.gov/12235267
https://pubmed.ncbi.nlm.nih.gov/12235267
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(19)
Hematopoietic stem cells (HSCs) can be identified by a “side population” (SP) phenotype. Previous studies have implicated the ATP binding cassette transporter genesMdr1a/1band/orBcrp1in the SP phenotype. To define the relative role of these trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0175e31d81ae9cfd45773e4efaf02e
https://pubmed.ncbi.nlm.nih.gov/12218177
https://pubmed.ncbi.nlm.nih.gov/12218177