Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lu RA"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Accurate chromosome segregation during cell division relies on coordinated actions of microtubule (MT)-based motor proteins in the mitotic spindle. Kinesin-14 motors play vital roles in spindle assembly and maintenance by crosslinking antipa
Externí odkaz:
https://doaj.org/article/77320487777b4eff9c9a946a1361c7df
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Mutations in the microtubule-associated motor protein KIF1A lead to severe neurological conditions known as KIF1A-associated neurological disorders (KAND). Despite insights into its molecular mechanism, high-resolution structures of KIF1A-mi
Externí odkaz:
https://doaj.org/article/55ded18659ae49698b2622dc23011f92
Publikováno v:
Zhongguo quanke yixue, Vol 27, Iss 11, Pp 1320-1325 (2024)
Background Carotid plaque is an important early predictive signal of clinical carotid atherosclerosis, the association between homocysteine (Hcy) and carotid plaque is well recognized, however, the correlation between Hcy and carotid plaque in postme
Externí odkaz:
https://doaj.org/article/99f0c58b54804c4591371420dfbd2d2c
Autor:
Lu Rao, Arne Gennerich
Publikováno v:
Cells, Vol 13, Iss 4, p 330 (2024)
Dynein, an ancient microtubule-based motor protein, performs diverse cellular functions in nearly all eukaryotic cells, with the exception of land plants. It has evolved into three subfamilies—cytoplasmic dynein-1, cytoplasmic dynein-2, and axonema
Externí odkaz:
https://doaj.org/article/554660b7b09b4553906725e785bc3adf
Autor:
Zhijun Wang, Lili Fu, Dongliang Liu, Dongxu Tang, Kun Liu, Lu Rao, Jinyu Yang, Yi Liu, Yuesheng Li, Huangqin Chen, Xiaojie Yang
Publikováno v:
Gels, Vol 9, Iss 7, p 571 (2023)
Hydrogels are materials consisting of a network of hydrophilic polymers. Due to their good biocompatibility and hydrophilicity, they are widely used in biomedicine, food safety, environmental protection, agriculture, and other fields. This paper summ
Externí odkaz:
https://doaj.org/article/d7576121e78b40e3bff628dabb01a8fe
Autor:
Xiaoqin Fu, Lu Rao, Peijun Li, Xinglei Liu, Qi Wang, Alexander I Son, Arne Gennerich, Judy Shih-Hwa Liu
Publikováno v:
eLife, Vol 11 (2022)
Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined. Here, we demonstrate that DCX negatively r
Externí odkaz:
https://doaj.org/article/64373830ab2f4cd1846a64ce86b5d746
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Cytoplasmic dynein contains three active AAA + ATPases (AAA1, 3 and 4), but only the functions of AAA1 and 3 are known. Here, we perform single-molecule fluorescence and optical tweezers studies and show that AAA4 controls the priming stroke of the m
Externí odkaz:
https://doaj.org/article/66f8acdf26af494eacd6829c2907021d
Publikováno v:
Open Medicine, Vol 14, Iss 1, Pp 663-672 (2019)
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) accelerated vascular diseases progression, like atherosclerosis and restenosis. MicroRNAs were reported to participate in modulating diverse cellular processes. Here, we foc
Externí odkaz:
https://doaj.org/article/9daa0164074548989d9477ed8f946675
Autor:
Bin Huang, Chizhou Wu, Yuzhu Hu, Lu Rao, Mingzhe Yang, Mengyao Zhao, Huangqin Chen, Yuesheng Li
Publikováno v:
Polymers, Vol 14, Iss 24, p 5399 (2022)
Conventional medical agents for oral squamous cell carcinoma (OSCC) with some adverse effects no longer meet the needs of the public. In this study, the prognosis-related hub genes of osmanthus-targeted therapy for OSCC were predicted and analyzed by
Externí odkaz:
https://doaj.org/article/e8f97651ff6e459c87bf5bf59adc3d6b
Autor:
Bin Huang, Mengyao Zhao, Mingzhe Yang, Lu Rao, Chizhou Wu, Yuzhu Hu, Huangqin Chen, Yuesheng Li
Publikováno v:
Gels, Vol 8, Iss 10, p 659 (2022)
There is an urgent need to find long-acting, natural osteogenesis-promoting drug systems. In this study, first the potential targets and mechanism of osmanthus fragrans (O. fragrans) extract in regulating osteogenic differentiation based on autophagy
Externí odkaz:
https://doaj.org/article/bba63fdcbf0a4ced940ef40ee6d28e0b