Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Lu Q Le"'
Autor:
Anand K Ganesan, Hsiang Ho, Brian Bodemann, Sean Petersen, Jayavani Aruri, Shiney Koshy, Zachary Richardson, Lu Q Le, Tatiana Krasieva, Michael G Roth, Pat Farmer, Michael A White
Publikováno v:
PLoS Genetics, Vol 4, Iss 12, p e1000298 (2008)
Melanin protects the skin and eyes from the harmful effects of UV irradiation, protects neural cells from toxic insults, and is required for sound conduction in the inner ear. Aberrant regulation of melanogenesis underlies skin disorders (melasma and
Externí odkaz:
https://doaj.org/article/6e8cb1d7e6c9434d943c7b29e3b17084
Autor:
Frank B. Furnari, Corina Anastasaki, Shan Bian, Howard A. Fine, Tomoyuki Koga, Lu Q. Le, Fausto J. Rodriguez, David H. Gutmann
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/ce1de40fcd154f57adc3a04a5aab3822
Autor:
Chunhui Jiang, Ashwani Kumar, Ze Yu, Tracey Shipman, Yong Wang, Renee M. McKay, Chao Xing, Lu Q. Le
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Neurofibromatosis type 1 (NF1) is one of the most common tumor-predisposing genetic disorders. Neurofibromas are NF1-associated benign tumors. A hallmark feature of neurofibromas is an abundant collagen-rich extracellular matrix (ECM) that constitute
Externí odkaz:
https://doaj.org/article/c58d1cf601994e0eb228352447eddcec
Autor:
Corina Anastasaki, Juan Mo, Ji-Kang Chen, Jit Chatterjee, Yuan Pan, Suzanne M. Scheaffer, Olivia Cobb, Michelle Monje, Lu Q. Le, David H. Gutmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Neuronal activity is emerging as a driver of nervous system tumors. Here, the authors show in mouse models of Neurofibromatosis-1 (NF1) that Nf1 mutations differentially drive both central and peripheral nervous system tumor growth in mice through re
Externí odkaz:
https://doaj.org/article/da669970414141a2a3165032a695c25b
Autor:
Jean-Philippe Brosseau, Adwait A. Sathe, Yong Wang, Toan Nguyen, Donald A. Glass, Chao Xing, Lu Q. Le
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021)
Abstract Neurofibromatosis Type I (NF1) is a neurocutaneous genetic syndrome characterized by a wide spectrum of clinical presentations, including benign peripheral nerve sheath tumor called neurofibroma. These tumors originate from the Schwann cell
Externí odkaz:
https://doaj.org/article/8889596d577b433e91c1f13df8ae59f6
Publikováno v:
JID Innovations, Vol 2, Iss 1, Pp 100061- (2022)
Physician‒scientists have made countless discoveries, and their dwindling numbers are a significant concern. Although dermatology has become an increasingly popular destination for physician‒scientist trainees, the proportion of trainees who purs
Externí odkaz:
https://doaj.org/article/39ec0f50ea00410ca3a645e69438c708
Autor:
Edem Tchegnon, Chung-Ping Liao, Elnaz Ghotbi, Tracey Shipman, Yong Wang, Renee M. McKay, Lu Q. Le
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
Dry eye disease affects over 16 million adults in the US, and the majority of cases are due to Meibomian gland dysfunction. Unfortunately, the identity of the stem cells involved in Meibomian gland development and homeostasis is not well elucidated.
Externí odkaz:
https://doaj.org/article/d956a931a5de4fc7b40d381a8a33922c
Publikováno v:
JID Innovations, Vol 1, Iss 3, Pp 100044- (2021)
Neurofibromatosis type 1 (NF1) is one of the most common neurocutaneous genetic disorders, presenting with different cutaneous features such as café-au-lait macules, intertriginous skin freckling, and neurofibromas. Although most of the disease mani
Externí odkaz:
https://doaj.org/article/1be544bfce7040a89934faf5cdaf43df
Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling
Autor:
Zhiguo Chen, Stephen Li, Juan Mo, Eric Hawley, Yong Wang, Yongzheng He, Jean-Philippe Brosseau, Tracey Shipman, D. Wade Clapp, Thomas J. Carroll, Lu Q. Le
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Schwannomas are tumors of the Schwann cells that cause chronic pain, numbness, and potentially life-threatening impairment of vital organs. Despite the identification of causative genes, including NF2 (Merlin), INI1/SMARCB1, and LZTR1, the exact mole
Externí odkaz:
https://doaj.org/article/c7767e2f0eef47f9a10e9ecb1c27e92d
Autor:
Jean-Philippe Brosseau, Chung-Ping Liao, Yong Wang, Vijay Ramani, Travis Vandergriff, Michelle Lee, Amisha Patel, Kiyoshi Ariizumi, Lu Q. Le
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Germline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironm
Externí odkaz:
https://doaj.org/article/9469062130ae408ba5616d707d78a78d