Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Lu Min, Wong"'
Autor:
Julyun Oh, Charles Kirsh, Jing-Ping Hsin, Kelly C. Radecki, Alexandre Zampieri, Diane Manry, Yuta Ando, Sara Miller, Jamie Chan, Ethan McLeod, Kathleen M. Cunningham, Lu Min Wong, Han Xu, Alexander Kamb
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109913- (2024)
Summary: Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E) which are widely expressed on cancer cells. Noncancerous cells—despite high expre
Externí odkaz:
https://doaj.org/article/2f54004c83044be5bd8ac35ee92cdfc3
Autor:
J Randolph Hecht, Mark Sandberg, Xueyin Wang, Aaron Martin, Daniel Nampe, Grant Gabrelow, Chuck Li, Michele Mcelvain, Wen-Hua Lee, Sanam Shafaattalab, Sara Martire, Fernando Fisher, Yuta Ando, Edwin Liu, David Ju, Jing-Ping Hsin, Alexandre Zampieri, Diane Simeone, Scott Kopetz, Maria Pia Morelli, Mitesh Borad, Theodore Welling, Sandip Patel, Edward Garon, Kedar Kirtane, Frederick Locke, John Welch, Eric Ng, William Go, Armen Mardiros, David Maloney, Lu-Min Wong, Alexander Kamb, Han Xu, Julian Molina
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1735e53f27307384385c169464cb2129
https://doi.org/10.1136/jitc-2022-sitc2022.0229
https://doi.org/10.1136/jitc-2022-sitc2022.0229
Autor:
Mark L. Sandberg, Xueyin Wang, Aaron D. Martin, Daniel P. Nampe, Grant B. Gabrelow, Chuck Z. Li, Michele E. McElvain, Wen-Hua Lee, Sanam Shafaattalab, Sara Martire, Fernando A. Fisher, Yuta Ando, Edwin Liu, David Ju, Lu Min Wong, Han Xu, Alexander Kamb
Publikováno v:
Science Translational Medicine. 14
TheCEACAM5gene product [carcinoembryonic antigen (CEA)] is an attractive target for colorectal cancer because of its high expression in virtually all colorectal tumors and limited expression in most healthy adult tissues. However, highly active CEA-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b937aafb9e034f95524df0c50694f753
https://doi.org/10.1126/scitranslmed.abm0306
https://doi.org/10.1126/scitranslmed.abm0306
Autor:
Xueyin, Wang, Lu Min, Wong, Michele E, McElvain, Sara, Martire, Wen-Hua, Lee, Chuck Z, Li, Fernando A, Fisher, Ruchika L, Maheshwari, Ming Lun, Wu, Maria C, Imun, Rabi, Murad, Dora, Toledo Warshaviak, Jun, Yin, Alexander, Kamb, Han, Xu
Publikováno v:
Toxicology and Applied Pharmacology. 437:115894
Cell therapy is an emerging therapeutic modality with the power to exploit new cancer targets and potentially achieve positive outcomes for patients with few other options. Like all synthetic treatments, cell therapy has the risk of toxicity via unpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30232859dc2cfa9337a62aeec9b210a
https://doi.org/10.1016/j.taap.2022.115894
https://doi.org/10.1016/j.taap.2022.115894
Autor:
Maria Imun, Mark L. Sandberg, Yuta Ando, Wen-Hua Lee, Xueyin Wang, Fernando Fisher, Michele McElvain, Kiran Deshmukh, Agnes E. Hamburger, Han Xu, Lu-Min Wong, Chuck Li, Breanna DiAndreth, Alexander Kamb, David M.C. Ju, Grant B Gabrelow, Dora Toledo-Warshaviak, Sanam Shafaattalab, Daniel P Nampe, Talar Tokatlian, Mark E. Daris, Shruti Sharma, Edwin Liu, Jee-Young Mock, Martin S. Naradikian, Kristian Bolanos-Ibarra, Aaron D. Martin, Grace E. Asuelime
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A131-A131
BackgroundMesothelin (MSLN) and carcinoembryonic antigen (CEA) are classic tumor-associated antigens that are expressed in many solid tumors including the majority of lung, colorectal and pancreatic cancers. However, both MSLN and CEA are also expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::210c828c83b6d00261fd0c8831789f2c
https://doi.org/10.1136/jitc-2021-sitc2021.122
https://doi.org/10.1136/jitc-2021-sitc2021.122
Autor:
Claire L. M. Jackson, Bradley Henkle, Matthew R. Lee, Brad Herberich, Andrew Tasker, Samer Chmait, Qiurong Liu, Christiaan J. M. Saris, Faye Hsieh, Liping H. Pettus, Christopher Mohr, Lisa Sherman, Ryan Wurz, Lu Min Wong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1226-1229
Structure-activity relationship (SAR) investigations of a novel class of triazolopyridazinone p38α mitogen activated protein kinase (MAPK) inhibitors are disclosed. From these studies, increased in vitro potency was observed for 2,6-disubstituted ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9647181f2f2fd256c513ab351fdba20b
https://doi.org/10.1016/j.bmcl.2011.11.067
https://doi.org/10.1016/j.bmcl.2011.11.067
Autor:
Christiaan J. M. Saris, Lu Min Wong, Brad Herberich, Qiurong Liu, Bradley Henkle, Matthew R. Lee, Ryan Wurz, Liping H. Pettus, Christopher Mohr, Sharon X. Mu, Faye Hsieh, Matthew H. Plant, Samer Chmait, Helen J. McBride, Shimin Xu, Andrew Tasker, Lisa Sherman
Publikováno v:
Journal of Medicinal Chemistry. 53:2973-2985
The p38α mitogen-activated protein (MAP) kinase is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5255318d383925bfacd6a667356c7235
https://doi.org/10.1021/jm100095x
https://doi.org/10.1021/jm100095x
Autor:
David Powers, Guo-Qiang Cao, Scott Middleton, Lisa Sherman, Kelvin Sham, Dawei Zhang, Partha P. Chakrabarti, Faye Hsieh, Andrew Tasker, Yanyan Tudor, Bradley Henkle, Shimin Xu, Lu Min Wong, Ryan Wurz, Liping H. Pettus, Matthew R. Lee, Robert M. Rzasa, Violeta Yu, Christiaan J. M. Saris, Matthew H. Plant, Rashid Syed
Publikováno v:
Journal of Medicinal Chemistry. 51:6280-6292
The p38 mitogen-activated protein kinase (MAPK) is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7087b9c4f5722d23b003b38ab86133ff
https://doi.org/10.1021/jm8005405
https://doi.org/10.1021/jm8005405
Autor:
Peter H. Schafer, Rebecca T. Patterson, D. I. Stirling, Michael A. Shirley, Kate Blease, Lu Min Wong, George W. Muller, Laura G. Corral, Heather Raymon, Darius Babusis, Hon-Wah Man, Yang Tang, Roger Shen-Chu Chen, Jim Leisten
Publikováno v:
Journal of Medicinal Chemistry. 52:1522-1524
In this communication, we report the discovery of 1S (apremilast), a novel potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-alpha inhibitor. The optimization of previously reported 3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d477da9bf927b28bf8be6aacbf81a7
https://doi.org/10.1021/jm900210d
https://doi.org/10.1021/jm900210d
Autor:
Laura G. Corral, Patrick A. J. Haslett, George W. Muller, Roger Chen, Lu-Min Wong, Christopher J. Ocampo, Rebecca T. Patterson, David I. Stirling, Gilla Kaplan
Publikováno v:
The Journal of Immunology. 163:380-386
TNF-α mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown thalidomide to be a relatively selective inhibitor of TNF-α production in vivo and in vitro. Additionally, we have recently repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d67d661d10ee23ce4e9db387a346728d
https://doi.org/10.4049/jimmunol.163.1.380
https://doi.org/10.4049/jimmunol.163.1.380