Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Lu Gaohua"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 12, Pp 1547-1551 (2022)
Abstract The phase distribution model, proposed by Atkinson and Begg in 1990, has been widely used for predicting breastmilk‐to‐plasma drug concentration ratio. However, misrepresentations of the equations have been noted in recent publications.
Externí odkaz:
https://doaj.org/article/2070a3d5d02c48fbb2fb7f2bfdbc196d
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16224 (2023)
A permeability-limited physiologically based pharmacokinetic (PBPK) model featuring four subcompartments (corresponding to the intracellular and extracellular water of the tissue, the residual plasma, and blood cells) for each tissue has been develop
Externí odkaz:
https://doaj.org/article/de8213100d24426d8ee7e191cae0ce3e
Autor:
Caroline Sychterz, Iain Gardner, Manting Chiang, Ramakrishna Rachumallu, Sibylle Neuhoff, Vidya Perera, Samira Merali, Brian J. Schmidt, Lu Gaohua
Publikováno v:
Metabolites, Vol 12, Iss 10, p 1001 (2022)
Physiologically based pharmacokinetic (PBPK) modeling has a number of applications, including assessing drug–drug interactions (DDIs) in polymorphic populations, and should be iteratively refined as science progresses. The Simcyp Simulator is annua
Externí odkaz:
https://doaj.org/article/7fd1513fad8a4539b077960c88a087e4
Akademický článek
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Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 17:1103-1124
Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH-partition hypothesis form the theoretical base to define the impact of pH
Akademický článek
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Publikováno v:
Protein Degradation with New Chemical Modalities ISBN: 9781788016865
Many examples of PROTACs possessing in vivo efficacy in pre-clinical studies have now been disclosed. While building pharmacokinetic (PK)/pharmacodynamic (PD) relationships is recognized as a key activity in small-molecule drug discovery to support t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20bd3803ad89dfc67765bf21eb34f214
https://doi.org/10.1039/9781839160691-00075
https://doi.org/10.1039/9781839160691-00075
Publikováno v:
Drug discovery today. Technologies. 31
Proteolysis Targeting Chimeras (PROTACs) are a rapidly expanding new therapeutic modality inducing selective protein degradation and offering the potential of a differentiated pharmacological profile across multiple therapeutic areas. As the repertoi
Publikováno v:
Metabolite Safety in Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca28366c4363c1ea0a8824f2f8e74019
https://doi.org/10.1002/9781118949689.ch8
https://doi.org/10.1002/9781118949689.ch8
Publikováno v:
British Journal of Clinical Pharmacology. 74:873-885
Aims Pregnant women are usually not part of the traditional drug development programme. Pregnancy is associated with major biological and physiological changes that alter the pharmacokinetics (PK) of drugs. Prediction of the changes to drug exposure