Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Luísa, Perin"'
Autor:
Kátia da Silva Fonseca, Luísa Perin, Nívia Carolina Nogueira de Paiva, Beatriz Cristiane da Silva, Thays Helena Chaves Duarte, Flávia de Souza Marques, Guilherme de Paula Costa, Israel Molina, Rodrigo Correa-Oliveira, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro
Publikováno v:
Pathogens, Vol 10, Iss 6, p 729 (2021)
As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. The
Externí odkaz:
https://doaj.org/article/50db52f0a3a34ad5a6b8e8d640dd002a
Autor:
Ayla das Chagas Almeida, Raíssa Soares Meinel, Yasmim Lopes Leal, Thiago P. Silva, Nícolas Glanzmann, Débora Vasconcelos Costa Mendonça, Luísa Perin, Edézio Ferreira Cunha-Júnior, Eduardo A. F. Coelho, Rossana C. N. Melo, Adilson David da Silva, Elaine Soares Coimbra
Publikováno v:
Parasitology Research. 121:1389-1406
Visceral leishmaniasis (VL) is the most severe clinical form of leishmaniasis, being fatal if untreated. In search of a more effective treatment for VL, one of the main strategies is the development and screening of new antileishmanial compounds. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06b75ddedfedae9a8034125f3b874d6
https://doi.org/10.1007/s00436-022-07431-9
https://doi.org/10.1007/s00436-022-07431-9
Autor:
Luciana da Fonseca Medeiros, Cláudia Martins Carneiro, Paula Melo de Abreu Vieira, Luísa Perin, Lívia Carvalho Mendes, Kátia da Silva Fonseca, Thaís Vieira Carvalho Silva, Flávia de Souza Marques, Thays Helena Chaves Duarte, Nívia Carolina Nogueira-Paiva, Fernando Augusto Siqueira Mathias, Aline Coelho das Mercês, Viviane Flores Xavier, Aline Tonhela Ferraz
Publikováno v:
Parasitology Research. 120:3475-3486
With the control of vectorial transmission of Chagas disease caused by metacyclic trypomastigotes (MT) in endemic countries, other pathways of infection have become important. The infection caused by blood trypomastigotes (BT) is relevant in places w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9f3ace3259b1849c8b067232021d39
https://doi.org/10.1007/s00436-021-07236-2
https://doi.org/10.1007/s00436-021-07236-2
Autor:
Jamil S. Oliveira, Myron Christodoulides, Ricardo Andrez Machado-de-Ávila, Patrícia A.F. Ribeiro, Lívia M. Carvalho, Bethina T. Steiner, Vívian T. Martins, Grasiele S.V. Tavares, Daysiane de Oliveira, Luísa Perin, Thaís T.O. Santos, Fernanda F. Ramos, Eduardo A.F. Coelho, Daniel Dias, Débora V.C. Mendonça, Bruno Mendes Roatt, Daniela P. Lage, Antônio Lúcio Teixeira, Amanda S. Machado, Maria Victoria Humbert, João A. Oliveira-da-Silva
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-13 (2020)
Leishmaniases are neglected diseases caused by infection with Leishmania parasites and there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic recombinant vaccine against visceral leishmaniasis (VL) called Chime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427ef9bc81af0da21fb3768708695488
http://link.springer.com/article/10.1038/s41541-020-00224-0
http://link.springer.com/article/10.1038/s41541-020-00224-0
Autor:
Elaine Soares Coimbra, Vinicio T.S. Coelho, Patrícia A.F. Ribeiro, Guilherme R. Pereira, Guilherme Firmo De Matos, Luísa Perin, Pedro Henrique De Almeida Simões Neves, Eduardo A.F. Coelho, Grasiele S.V. Tavares, Andreza Cristina Gomes Ferreira, Daniel Dias, Débora V.C. Mendonça, Fernanda Ludolf, Daniela P. Lage, Luciana M.R. Antinarelli, Tauane G. Soyer, Miguel A. Chávez-Fumagalli
Publikováno v:
Experimental Parasitology. 199:30-37
The treatment against leishmaniasis presents problems, since the currently used drugs are toxic and/or have high costs. In addition, parasite resistance has increased. As a consequence, in this study, a chloroquinolin derivative, namely 7-chloro-N,N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd00ae1668a2bd906ceb49f8607fde76
https://doi.org/10.1016/j.exppara.2019.02.019
https://doi.org/10.1016/j.exppara.2019.02.019
Autor:
Daniela P, Lage, Patrícia A F, Ribeiro, Daniel S, Dias, Débora V C, Mendonça, Fernanda F, Ramos, Lívia M, Carvalho, Daysiane, de Oliveira, Bethina T, Steiner, Vívian T, Martins, Luísa, Perin, Amanda S, Machado, Thaís T O, Santos, Grasiele S V, Tavares, João A, Oliveira-da-Silva, Jamil S, Oliveira, Bruno M, Roatt, Ricardo A, Machado-de-Ávila, Antônio L, Teixeira, Maria V, Humbert, Eduardo A F, Coelho, Myron, Christodoulides
Publikováno v:
NPJ Vaccines
Leishmaniases are neglected diseases caused by infection with Leishmania parasites and there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic recombinant vaccine against visceral leishmaniasis (VL) called Chime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c3f8cc034066e203c6b63b6ed2ae782
https://pubmed.ncbi.nlm.nih.gov/32821440
https://pubmed.ncbi.nlm.nih.gov/32821440
Autor:
Paula Melo de Abreu Vieira, Israel Molina, Rodrigo Correa-Oliveira, Glauco Henrique Balthazar Nardotto, Luísa Perin, Cláudia Martins Carneiro, Kátia da Silva Fonseca, Leonardo Santos Ribeiro Pinto, Thaís Fernanda Rodrigues Bastos Mendes, Beatriz Oliveira Paiva
Publikováno v:
The Journal of antimicrobial chemotherapy. 75(8)
Objectives To evaluate the population pharmacokinetics of different benznidazole treatment regimens and the drug’s biodistribution in mice. Methods Two hundred mice were divided into five groups according to benznidazole dosing regimens: (1) 100 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daccb8d0f7b256ec861c957e823e836
https://pubmed.ncbi.nlm.nih.gov/32356873
https://pubmed.ncbi.nlm.nih.gov/32356873
Autor:
Lívia M. Carvalho, Cláudia Martins Carneiro, Paula Melo de Abreu Vieira, Thais Vieira de Carvalho, João Vitor Madeira, Kátia da Silva Fonseca, Rodrigo Correa-Oliveira, Israel Molina, Luciana da Fonseca Medeiros, Luísa Perin
Publikováno v:
Experimental parasitology. 210
Studies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b375e9151fbf8b28aa1782f316fc2e6d
https://pubmed.ncbi.nlm.nih.gov/31978394
https://pubmed.ncbi.nlm.nih.gov/31978394
Autor:
Beatriz Cristiane da Silva, Thays Helena Chaves Duarte, Nívia Carolina Nogueira de Paiva, Kátia da Silva Fonseca, Israel Molina, Paula Melo de Abreu Vieira, Guilherme de Paula Costa, Flávia de Souza Marques, Luísa Perin, Cláudia Martins Carneiro, Rodrigo Correa-Oliveira
Publikováno v:
Pathogens
Volume 10
Issue 6
Pathogens, Vol 10, Iss 729, p 729 (2021)
Scientia
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Volume 10
Issue 6
Pathogens, Vol 10, Iss 729, p 729 (2021)
Scientia
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Trypanosoma cruzi; Benznidazol; Estratègies terapèutiques Trypanosoma cruzi; Benznidazol; Estrategias terapéuticas Trypanosoma cruzi; Benznidazole; Therapeutic strategies As the development of new drugs for Chagas disease is not a priority due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca01c69f04a993859ebdf112aee699d
https://doi.org/10.3390/pathogens10060729
https://doi.org/10.3390/pathogens10060729
Autor:
Luciana M.R. Antinarelli, Luísa Perin, Grasiele S.V. Tavares, Daniela P. Lage, Elaine Soares Coimbra, João A. Oliveira-da-Silva, Denis F. Alvarenga, Patrícia A.F. Ribeiro, Geraldo Célio Brandão, Jessica K.T. Sousa, Fernanda Ludolf, Eduardo A.F. Coelho, Bianka A. Oliveira, Vinicio T.S. Coelho, Guilherme R. Pereira, Miguel A. Chávez-Fumagalli, Vandack Nobre, Daniel Dias, Débora V.C. Mendonça
Publikováno v:
Parasitology international. 73
The identification of new therapeutics to treat leishmaniasis is desirable, since available drugs are toxic and present high cost and/or poor availability. Therefore, the discovery of safer, more effective and selective pharmaceutical options is of u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013d93b575235d887428c6db0b2dce50
https://pubmed.ncbi.nlm.nih.gov/31362122
https://pubmed.ncbi.nlm.nih.gov/31362122