Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE

Autor: Diogo Pestana, Diana Teixeira, Manuela Meireles, Cláudia Marques, Sónia Norberto, Carla Sá, Virgínia C. Fernandes, Luísa Correia-Sá, Ana Faria, Luísa Guardão, João T. Guimarães, Wendy N. Cooper, Ionel Sandovici, Valentina F. Domingues, Cristina Delerue-Matos, Rosário Monteiro, Miguel Constância, Conceição Calhau

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)

Abstract Endocrine-disrupting chemicals such as p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated in the obesity and diabetes epidemic. Thus, it is hypothesized that p,p’-DD

Externí odkaz: https://doaj.org/article/b3abd049ed6f4508bafbd0af443ec779

Effect of chrysin on changes in intestinal environment and microbiome induced by fructose-feeding in rats

Autor: Cláudia Marques, João Tiago Guimarães, Nelson Andrade, Elisa Keating, Cláudia G. Silva, Fátima Martel, Ilda Rodrigues, Luísa Guardão, Conceição Calhau, Sara Andrade

Publikováno v: Food & Function. 10:4566-4576

Intake of fructose-containing sugars is epidemiological and experimentally linked to metabolic syndrome (MS). We recently verified that the dietary polyphenol chrysin was able to abolish some of the metabolic changes induced by fructose-feeding in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8769f0b946263d49e2361e7ebbadbfb
https://doi.org/10.1039/c9fo01142k

Exploring the in vitro and in vivo compatibility of PLA, PLA/GNP and PLA/CNT-COOH biodegradable nanocomposites: Prospects for tendon and ligament applications

Autor: Rui Miranda Guedes, V.C. Pinto, Luísa Guardão, Raquel Costa-Almeida, Ilda Rodrigues, Raquel Soares

Publikováno v: Journal of Biomedical Materials Research Part A. 105:2182-2190

Anterior cruciate ligament (ACL) reconstructive surgeries are the most frequent orthopedic procedures in the knee. Currently, existing strategies fail in completely restoring tissue functionality and have a high failure rate associated, presenting a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6266f2d08bfb5d4d1a1f72f1bca09a23
https://doi.org/10.1002/jbm.a.36075

Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Control?

Autor: Pedro Vendeira, Carla Costa, Liliana Leite, Pedro Gomes, Luísa Guardão, Ilda Rodrigues, A. Castela, Ricardo Silvestre, Rui Chilro, Ronald Virag

Publikováno v: Journal of Cellular Biochemistry. 118:82-91

Erectile dysfunction (ED) is a complication of diabetes, condition responsible for causing endothelial dysfunction (EDys) and hampering repair mechanisms. However, scarce information is available linking vasculogenesis mediated by Endothelial Progeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73ff9e60bad15f108587f7a86eb5c13d
https://doi.org/10.1002/jcb.25613

Excess perigestational folic acid exposure induces metabolic dysfunction in post-natal life

Autor: Fátima Martel, Elisa Keating, Conceição Calhau, João R. Araújo, Rita Fernandes, Ana Correia-Branco, Manuela Meireles, João Tiago Guimarães, Luísa Guardão

Publikováno v: CIÊNCIAVITAE
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

The aim of this study was to understand whether high folic acid (HFA) exposure during the perigestational period induces metabolic dysfunction in the offspring, later in life. To do this, female Sprague–Dawley rats (G0) were administered a dose of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a89be7c535352a71cf2a900fcb4870
https://ciencia.ucp.pt/en/publications/a9d856dc-1997-481b-87b4-98b2c6d913bd