Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Luís Gales"'
Publikováno v:
Molecules, Vol 29, Iss 4, p 895 (2024)
Amyloidosis is a group of protein misfolding diseases, which include spongiform encephalopathies, Alzheimer’s disease and transthyretin (TTR) amyloidosis; all of them are characterized by extracellular deposits of an insoluble fibrillar protein. TT
Externí odkaz:
https://doaj.org/article/e2cb028f3c3c42509bb2ec80da2fd1b5
Autor:
Luís Gales
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 3, Pp 497-498 (2024)
Externí odkaz:
https://doaj.org/article/02e1f4bb62164a1ebb940435c28b85b8
Autor:
Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Luís Gales, Armindo Salvador, Tânia Francisco, Jorge E. Azevedo
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102764- (2023)
Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind this phenomenon remains unexplored, and simple questions such as “is the
Externí odkaz:
https://doaj.org/article/1cf19b1fe0fc4b3b8ec2e7a924a0fbe5
Autor:
Rotchana Klaram, Tida Dethoup, Fátima P. Machado, Luís Gales, Decha Kumla, Salar Hafez Ghoran, Emília Sousa, Sharad Mistry, Artur M. S. Silva, Anake Kijjoa
Publikováno v:
Marine Drugs, Vol 21, Iss 6, p 344 (2023)
Five undescribed pentaketide derivatives, (R)-6,8-dihydroxy-4,5-dimethyl-3-methylidene-3,4-dihydro-1H-2-benzopyran-1-one (1), [(3S,4R)-3,8-dihydroxy-6-methoxy-4,5-dimethyl-1-oxo-3,4-dihydro-1H-isochromen-3-yl]methyl acetate (2), (R)-5, 7-dimethoxy-3-
Externí odkaz:
https://doaj.org/article/8e5702be233e4e7abb2aa356c247399c
Autor:
Fátima P. Machado, Inês C. Rodrigues, Aikaterini Georgopolou, Luís Gales, José A. Pereira, Paulo M. Costa, Sharad Mistry, Salar Hafez Ghoran, Artur M. S. Silva, Tida Dethoup, Emília Sousa, Anake Kijjoa
Publikováno v:
Marine Drugs, Vol 21, Iss 3, p 194 (2023)
An undescribed hybrid phenalenone dimer, talaropinophilone (3), an unreported azaphilone, 7-epi-pinazaphilone B (4), an unreported phthalide dimer, talaropinophilide (6), and an undescribed 9R,15S-dihydroxy-ergosta-4,6,8 (14)-tetraen-3-one (7) were i
Externí odkaz:
https://doaj.org/article/eba2cccf15af484b864372c28185fe7a
Autor:
Ana C. Reis, Boris A. Kolvenbach, Mohamed Chami, Luís Gales, Conceição Egas, Philippe F.-X. Corvini, Olga C. Nunes
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-23 (2019)
Abstract Background Microbial communities recurrently establish metabolic associations resulting in increased fitness and ability to perform complex tasks, such as xenobiotic degradation. In a previous study, we have described a sulfonamide-degrading
Externí odkaz:
https://doaj.org/article/0dd810ea15bc46ebaab0ff72b99e21a2
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 328 (2022)
Over recent decades, multidrug-resistant pathogens have become a global concern, with WHO even considering it one of the biggest threats to global health, food security, and development today, which led to the search for alternative antibacterial age
Externí odkaz:
https://doaj.org/article/46de613273f342b6af20876033d3545e
Autor:
Joana Cardoso, Joana Freitas-Silva, Fernando Durães, Diogo Teixeira Carvalho, Luís Gales, Madalena Pinto, Emília Sousa, Eugénia Pinto
Publikováno v:
Antibiotics, Vol 11, Iss 11, p 1488 (2022)
Fungal infections are one of the main causes of mortality and morbidity worldwide and taking into account the increasing incidence of strains resistant to classical antifungal drugs, the development of new agents has become an urgent clinical need. C
Externí odkaz:
https://doaj.org/article/d40f753d48ef4ff7bdae45a45c72545b
Autor:
Fátima P. Machado, Inês C. Rodrigues, Luís Gales, José A. Pereira, Paulo M. Costa, Tida Dethoup, Sharad Mistry, Artur M. S. Silva, Vitor Vasconcelos, Anake Kijjoa
Publikováno v:
Marine Drugs, Vol 20, Iss 11, p 672 (2022)
An unreported isocoumarin, (3S,4R)-4-hydroxy-6-methoxymellein (2), an undescribed propylpyridinium anthraquinone (4), and an unreported C-glucosyl resorcinol derivative, acetyl carnemycin E (5c), were isolated, together with eight previously reported
Externí odkaz:
https://doaj.org/article/c65fb4b6997b4a8eb6de58c7c3a1efcf
Autor:
Solida Long, Izadora L. Furlani, Juliana M. de Oliveira, Diana I. S. P. Resende, Artur M. S. Silva, Luís Gales, José A. Pereira, Anake Kijjoa, Quezia B. Cass, Regina V. Oliveira, Emília Sousa, Madalena M. M. Pinto
Publikováno v:
Molecules, Vol 26, Iss 16, p 5070 (2021)
In recent decades, fungi-derived naturally occurring quinazolines have emerged as potential drug candidates. Nevertheless, most studies are conducted for bioactivity assays, and little is known about their absorption, distribution, metabolism, and el
Externí odkaz:
https://doaj.org/article/c02d9b09174f4208890f6eba6f7a3406