Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Luís Ferreira Moita"'
Autor:
Tiago R. Velho, MD, Ricardo Ferreira, MD, Katharina Willmann, PhD, Dora Pedroso, PhD, Tiago Paixão, PhD, Rafael Maniés Pereira, CLP, Nádia Junqueira, MD, Nuno Carvalho Guerra, MD, Dulce Brito, PhD, Ana G. Almeida, PhD, Ângelo Nobre, MD, Thomas Köcher, PhD, Fausto Pinto, PhD, Luís Ferreira Moita, PhD
Publikováno v:
Critical Care Explorations, Vol 4, Iss 10, p e0763 (2022)
OBJECTIVES:. Cardiac surgery is frequently associated with significant postoperative bleeding. Platelet-dysfunction is the main cardiopulmonary bypass (CPB)-induced hemostatic defect. Not only the number of platelets decreases, but also the remaining
Externí odkaz:
https://doaj.org/article/13b76a98d91c4a46a0d87799bc0ab8d3
Autor:
Tiago R. Velho, MD, Rafael Maniés Pereira, CLP, Tiago Paixão, PhD, Nuno Carvalho Guerra, MD, Ricardo Ferreira, MD, Hugo Corte-Real, MD, Ângelo Nobre, MD, Luís Ferreira Moita, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 4, Iss 5, p e0682 (2022)
OBJECTIVES:. The Sequential Organ Failure Assessment (SOFA) score is a predictor of mortality in ICU patients. Although it is widely used and has been validated as a reliable and independent predictor of mortality and morbidity in cardiac ICU, few st
Externí odkaz:
https://doaj.org/article/7bb344078ad344deab7d1c4b8270ce2d
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-3 (2020)
Externí odkaz:
https://doaj.org/article/0b3139b92b8d40b7b240afceba830eea
Autor:
Susana Moreira, Raquel Rodrigues, André B. Barros, Nadja Pejanovic, Ana Neves-Costa, Dora Pedroso, Cláudia Pereira, Dina Fernandes, João Valença Rodrigues, Cristina Barbara, Luís Ferreira Moita
Publikováno v:
Frontiers in Medicine, Vol 4 (2017)
PurposeMetabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock
Externí odkaz:
https://doaj.org/article/ffcad939b6c2400db7f9bb7a66f414de
Autor:
Susana A Gonçalves, Diana Macedo, Helena Raquel, Pedro D Simões, Flaviano Giorgini, José S Ramalho, Duarte C Barral, Luís Ferreira Moita, Tiago Fleming Outeiro
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005995 (2016)
Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and ce
Externí odkaz:
https://doaj.org/article/b5e598c8111f482999db633fa738c153
Autor:
Peter Schlattmann, Thomas Lehmann, Tim Rahmel, Johannes Roth, Peter Kranke, Frank M Brunkhorst, Andreas Greinacher, Patrick Meybohm, Philipp Helmer, Stefan Hagel, Florian Rißner, Michael Bauer, Matthias Gründling, Sven-Olaf Kuhn, Christian Fuchs, Luis Ferreira Moita, Frank Bloos, Matthias Michael, Ulrike Schumacher, Matthias Unterberg, Daniel Thomas-Rüddel, Christiane Helbig, Johannes Ehler, Heiko Schenk, Thomas Köcher, Markus Gräler, Ann-Julika Heger, Sebastian Weis, Karen Dlubatz, Jakob Hammersen, Katja Leonhardt, René Markgraf, Franziska Röstel, Nicole Schwarze, Mariann Städtler, Wolfgang Vivas-Varela, Andre Hagedorn, Andrea Wittkowski, Florian Rumpf, Tobias Haas, Sebastian Hottenrott, Eva Kranke, Marianne Neuf, Anke Reppchen, Daniel Röder, Julius Schmidt
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Sepsis remains the major cause of death among hospitalised patients in intensive care. While targeting sepsis-causing pathogens with source control or antimicrobials has had a dramatic impact on morbidity and mortality of sepsis patients
Externí odkaz:
https://doaj.org/article/61a05aa5bd5545d9812046f23ab53e28
Autor:
Angelo Ferreira Chora, Dora Pedroso, Eleni Kyriakou, Nadja Pejanovic, Henrique Colaço, Raffaella Gozzelino, André Barros, Katharina Willmann, Tiago Velho, Catarina F Moita, Isa Santos, Pedro Pereira, Silvia Carvalho, Filipa Batalha Martins, João A Ferreira, Sérgio Fernandes de Almeida, Vladimir Benes, Josef Anrather, Sebastian Weis, Miguel P Soares, Arie Geerlof, Jacques Neefjes, Michael Sattler, Ana C Messias, Ana Neves-Costa, Luis Ferreira Moita
Publikováno v:
eLife, Vol 11 (2022)
Anthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. Here, we show
Externí odkaz:
https://doaj.org/article/32ef11be914c4b2e932acba420ab64bc
Autor:
Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes, Filip Van Immerseel, Rudi Beyaert, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-21 (2020)
Abstract The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete pr
Externí odkaz:
https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814
Autor:
Rita Cascão, Bruno Vidal, Tânia Carvalho, Inês Pascoal Lopes, Vasco C. Romão, João Goncalves, Luis Ferreira Moita, João Eurico Fonseca
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Background: We previously demonstrated that celastrol has significant anti-inflammatory and bone protective effects when administered via the intraperitoneal route. For further preclinical evaluation, an effective oral administration of celastrol is
Externí odkaz:
https://doaj.org/article/94e4c20a4ba642e19a8e7cbc6236a3ab
Publikováno v:
Swiss Medical Weekly, Vol 146, Iss 0708 (2016)
Externí odkaz:
https://doaj.org/article/df0495ed85544b1f8d869523dba97cf6