Výsledky vyhledávání - "Luís A. Vale-Silva"

Akademický článek

Long-term cancer survival prediction using multimodal deep learning

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract The age of precision medicine demands powerful computational techniques to handle high-dimensional patient data. We present MultiSurv, a multimodal deep learning method for long-term pan-cancer survival prediction. MultiSurv uses dedicated s

Externí odkaz: https://doaj.org/article/2d62f466731f45de90e5884414084733

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Akademický článek

Aminodi(hetero)arylamines in the Thieno[3,2-b]pyridine Series: Synthesis, Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Evaluation of Toxicity Using Non-Tumor Cells

Autor: M. Helena Vasconcelos, M. Inês Alvelos, Raquel T. Lima, Eugénia Pinto, Luís A. Vale-Silva, Rui M. V. Abreu, Isabel C. F. R. Ferreira, Daniela Peixoto, Ricardo C. Calhelha, Maria-João R. P. Queiroz

Publikováno v: Molecules, Vol 17, Iss 4, Pp 3834-3843 (2012)

Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling pr

Externí odkaz: https://doaj.org/article/7187e59570644070988ad265cc977d56

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Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates

Autor: Dominique Sanglard, Luís A. Vale-Silva, Emmanuel Beaudoing, Van Du T. Tran

Publikováno v: G3, vol. 7, no. 8, pp. 2413-2426
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2413-2426 (2017)

Candida glabrata is an important fungal pathogen which develops rapidly antifungal resistance in treated patients. It is known that azole treatments lead to antifungal resistance in this fungal species and that multidrug efflux transporters are invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698ebfa2f035fb1d52c4a933da7ebcdc
https://serval.unil.ch/resource/serval:BIB_CDBF97BBE25A.P001/REF.pdf

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Antifungal activity of the essential oil of Thymus villosus subsp. lusitanicus against Candida, Cryptococcus, Aspergillus and dermatophyte species

Autor: Luís A. Vale-Silva, Jéssica Pinto, Maria José Gonçalves, Eugénia Pinto, S. Vaz, Lígia Salgueiro, Karnjana Hrimpeng, Carlos Cavaleiro

Publikováno v: Industrial Crops and Products. 51:93-99

Composition and antifungal activity of the essential oil (EO) of Thymus villosus subsp. lusitanicus and its main components geranyl acetate, terpinen-4-ol, linalool and geraniol against clinically relevant yeasts and moulds were studied. EO from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15ef74a38b6f63f71dfb7bcf3c3f9459
https://doi.org/10.1016/j.indcrop.2013.08.033

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Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals

Autor: Jamel Eddouzi, Luís A. Vale-Silva, Dominique Sanglard, Steve L. Kelly, Mohamed Manai, Françoise Ischer, Josie E. Parker, Alix T. Coste

Publikováno v: Antimicrobial Agents and Chemotherapy. 57:3182-3193

Antifungal resistance of Candida species is a clinical problem in the management of diseases caused by these pathogens. In this study we identified from a collection of 423 clinical samples taken from Tunisian hospitals two clinical Candida species (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736a62632380779be372e31c1c1329ac
https://doi.org/10.1128/aac.00555-13

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Gain-of-Function Mutations in PDR1 , a Regulator of Antifungal Drug Resistance in Candida glabrata, Control Adherence to Host Cells

Autor: Salomé LeibundGut-Landmann, Dominique Sanglard, Luís A. Vale-Silva, Françoise Ischer

Publikováno v: Infect Immun

Candida glabrata is an emerging opportunistic pathogen that is known to develop resistance to azole drugs due to increased drug efflux. The mechanism consists of CgPDR1 -mediated upregulation of ATP-binding cassette transporters. A range of gain-of-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e0e10aea84951e24facb525d479533
https://doi.org/10.1128/iai.00074-13

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Aminodi(hetero)arylamines in the Thieno[3,2-b]pyridine Series: Synthesis, Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Evaluation of Toxicity Using Non-Tumor Cells

Autor: Rui M.V. Abreu, Maria João R. P. Queiroz, M. Helena Vasconcelos, Ricardo C. Calhelha, M. Inês Alvelos, Daniela Peixoto, Eugénia Pinto, Luís A. Vale-Silva, Raquel T. Lima, Isabel C.F.R. Ferreira

Publikováno v: Molecules, Vol 17, Iss 4, Pp 3834-3843 (2012)
Molecules
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Volume 17
Issue 4
Pages 3834-3843

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6f4b2a5dc22789860f73315f311398
https://doi.org/10.3390/molecules17043834

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Comparison of the Etest and a rapid flow cytometry-based method with the reference CLSI broth microdilution protocol M27-A3 for the echinocandin susceptibility testing of Candida spp

Autor: H. Ramos, V. Lopes, P. Pinto, Luís A. Vale-Silva, Eugénia Pinto

Publikováno v: European Journal of Clinical Microbiology & Infectious Diseases. 31:941-946

Reference broth microdilution protocols for the antifungal susceptibility testing (AST) of yeasts are available, but routine AST relies more on simpler alternatives. In this work, the Etest and a novel flow cytometry (FC) method were compared to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6883c93b2dd318e3bd8abc20d77911c
https://doi.org/10.1007/s10096-011-1390-z

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