Zobrazeno 1 - 10
of 1 853
pro vyhledávání: '"Lu, Gan"'
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-10 (2024)
Abstract Purpose To explore the effects of a single dose of uridine adenosine tetraphosphate (Up4A) administered through the tail vein, on the blood pressure of mice. Methods The mice were separated into three groups: the Up4A group, the norepinephri
Externí odkaz:
https://doaj.org/article/3c4621810d89483f8183d9ee7ad3f629
Publikováno v:
Diabetes & Metabolism Journal, Vol 48, Iss 4, Pp 503-517 (2024)
Several mitochondrial dysfunctions in obesity and diabetes include impaired mitochondrial membrane potential, excessive mitochondrial reactive oxygen species generation, reduced mitochondrial DNA, increased mitochondrial Ca2+ flux, and mitochondrial
Externí odkaz:
https://doaj.org/article/f1aa92f5558d4a44b4e607a518497842
Publikováno v:
Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)
Abstract The programmed death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) axis inhibits T cell activity, impairing anti‐tumor immunity. Blocking this axis with therapeutic antibodies is one of the most promising anti‐tumor immunotherapies. It
Externí odkaz:
https://doaj.org/article/87d266990ffa4fdeb0e793dd8cd90150
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract As a key factor in determining testis size and sperm number, sertoli cells (SCs) play a crucial role in male infertility. Heat stress (HS) reduces SCs counts, negatively impacting nutrient transport and supply to germ cells, and leading to s
Externí odkaz:
https://doaj.org/article/547167a38a3b47dd86be31e0602a8698
Autor:
Yidan Tang, Jiahui Wu, Changliang Liu, Lu Gan, Hai Chen, Ya-Lan Sun, Jin Liu, Yuan-Xiang Tao, Tao Zhu, Chan Chen
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background The pathogenesis of memory impairment, a common complication of chronic neuropathic pain (CNP), has not been fully elucidated. Schwann cell (SC)-derived extracellular vesicles (EVs) contribute to remote organ injury. Here, we show
Externí odkaz:
https://doaj.org/article/eb28ccc17f0048ef8bc9af26e338188e
Autor:
Lu Gan, Bin Zhao, Maki Inoue-Choi, Linda M. Liao, Barry I. Graubard, Stephanie J. Weinstein, Demetrius Albanes, Jiaqi Huang
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Background The impact of sodium intake on cardiovascular disease (CVD) health and mortality has been studied for decades, including the well-established association with blood pressure. However, non-linear patterns, dose–response associati
Externí odkaz:
https://doaj.org/article/16329dc6f28a42c9810896dc9c80f29e
Publikováno v:
Materials Today Bio, Vol 29, Iss , Pp 101308- (2024)
Surgery is one of the primary treatments for solid tumors. However, the incomplete resection of tumor cells and the immunosuppressive microenvironment make the issue of postsurgical tumor recurrence a great challenge. Furthermore, a wide range of req
Externí odkaz:
https://doaj.org/article/4c3eac02c982474cbadc68a6779c4f6d
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Background Chronic stress can induce stress-related hormones; norepinephrine (NE) is considered to have the highest potential in cancer. NE can stimulate the expression of hypoxia-inducible factor-1α (HIF-1α), which is associated with vascular endo
Externí odkaz:
https://doaj.org/article/08b23400672c4c8487d15930cc43df60
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e35128- (2024)
Climate-related disasters have been escalating worldwide, incurring major losses. Landslides have become one of the most destructive disasters, especially in China's mountainous areas. To address this, constructing emergency shelters and designing ev
Externí odkaz:
https://doaj.org/article/43292b371cf64af09630f75f473814c7
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105200- (2024)
Summary: Nanoparticles have shown great potential for tumor targeting delivery via enhanced permeability and retention effect. However, the tumor mechanical microenvironment, characterized by dense extracellular matrix (ECM), high tumor stiffness and
Externí odkaz:
https://doaj.org/article/daaa0314ef7f44d99e0722310b9c26e4