Výsledky vyhledávání

Differential-effects of tumor promoters and cytokines on protooncogene expression in a hematopoietic cytokine-dependent cell-line

Autor: Pa Algate, Kd Prevost, G Arana, Mw Mayo, Xy Wang, Mk White, Ja Mccubrey, Ls Steelman

Publikováno v: Oncology reports. 1(2)

In order to investigate the mechanisms by which cytokines and tumor promoters stimulate cell growth, the expression of genes implicated in the regulation of cellular proliferation were examined in an interleukin-3 (IL-3) dependent hematopoietic cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5317fd357388ed7eb3cd77127c7d0759
https://pubmed.ncbi.nlm.nih.gov/21607354

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Autocrine growth-factor secretion after transformation of human cytokine-dependent cells by viral and cellular oncogenes

Autor: Cr White, Pa Algate, Pe Hoyle, P Robbins, D Mylott, Xy Wang, Ew Davidian, Ls Steelman, Ja Mccubrey, Kd Prevost, Mk White

Publikováno v: International journal of oncology. 7(3)

The effects of viral and cellular oncogenes on a human erythroleukemic cell line (TF-1) were investigated. The TF-1 cell line required granulocyte/macrophage-colony stimulating factor (GM-CSF) for growth but this factor-dependency was abrogated by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21202cb569523ae78cf6a183dc1071e
https://pubmed.ncbi.nlm.nih.gov/21552876

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Differential-effects of viral and cellular oncogenes on the growth factor-dependency of hematopoietic-cells

Autor: D Mylott, Ls Steelman, Ew Davidian, Xy Wang, Mk White, P Robbins, Pa Algate, C White, Pe Hoyle, Ja Mccubrey, Kd Prevost

Publikováno v: International journal of oncology. 7(2)

The effects of different viral and cellular oncogenes on the cytokine-dependency of murine hematopoietic cell lines were compared. The myeloid FDC-P1 cell line was sensitive to abrogation of growth factor-dependency by the constitutive expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedc2b74f33f66cb1b3baeea82fe7181
https://pubmed.ncbi.nlm.nih.gov/21552839

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DIFFERENTIAL REGULATION OF GLUCOSE-TRANSPORTER EXPRESSION IN HEMATOPOIETIC-CELLS BY ONCOGENIC TRANSFORMATION AND CYTOKINE STIMULATION

Autor: Ja Mccubrey, Je Devente, Mk White, Ls Steelman, Mw Mayo, Dm Canupp, Pj Robbins

Publikováno v: Oncology Reports.

Malignant transformation by the v-src oncogene and mitogenic stimulation by interleukin-3 (IL-3) both increased glucose transport into a hematopoietic cell line. These increases were additive and correlated with elevations in the level of GLUT1 mRNA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6042242037cabc5a3bffa9a4b0ba8dda
https://doi.org/10.3892/or.1.1.17

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Effects of phorbol esters on an interleukin-3-dependent cell line

Autor: JA McCubrey, LS Steelman, G Sandlin, RS Riddle, DK Ways

Publikováno v: Blood. 76(1)

FDC-P1 is an interleukin-3 (IL-3)-dependent cell line that ceases to proliferate in the absence of IL-3. We have isolated variant cell lines from FDC-P1 that grow in response to phorbol myristate acetate (PMA). These variant cell lines (FD/PMA) have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bd7ed8de029f361a2d9f1ec4b6ec56
https://pubmed.ncbi.nlm.nih.gov/2364174

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Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells

Autor: Ls, Steelman, Pa, Algate, William Blalock, Xy, Wang, Kd, Prevost, Pe, Hoyle, Ja, Mccubrey

Publikováno v: Europe PubMed Central

To elucidate the relationship between malignant transformation and cytokine receptor expression, the interleukin-3 receptor (IL-3R) complex was examined in an IL-3-dependent parental line and cells transformed by cytokines and oncogenes. In IL-3-depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::11c0f0b0f7600743b984cccc7b71c2de
http://europepmc.org/abstract/med/8642872

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Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells

Autor: Ja, Mccubrey, Jt, Lee, Ls, Steelman, William Blalock, Pw, Moye, Chang F, Pearce M, Jg, Shelton, Mk, White, Ra, Franklin, Sc, Pohnert

Publikováno v: Europe PubMed Central

The PI3K/Akt and Raf/MEK/ERK signal transduction cascades are pivotal in transmitting signals from membrane receptors to downstream targets that regulate apoptosis, gene expression, and cell growth. The abilities of activated PI3K, Akt, Raf, and MEK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::59f0563e7a09345c59aae97ca22fb9a0
http://europepmc.org/abstract/med/11531015

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