Zobrazeno 1 - 10
of 4 322
pro vyhledávání: '"Lrp6"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract The Wnt/β-catenin signaling pathway is crucial for embryonic development and adult tissue homeostasis. Dysregulation of Wnt signaling is linked to various developmental anomalies and diseases, notably cancer. Although numerous regulators of
Externí odkaz:
https://doaj.org/article/c3ba54daa57447849f20e4f956dea977
Autor:
Tongqing Chen, Yiming Wang, Jia-Lin Yang, Jiahui Ni, Keyuan You, Xuesong Li, Yuping Song, Xu Wang, Jian Li, Xiaoyan Shen, Yujuan Fan, Yan You
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107516- (2024)
Atherosclerotic-related acute cardiovascular events remain a leading cause of mortality worldwide, yet there are currently no pharmacological interventions available to address plaque formation or plaque rupture (PR). Here we reported that gentisic a
Externí odkaz:
https://doaj.org/article/102634deaa404f6bb452ac73d9184a3e
Autor:
Lifeng Tan, Mengfang Yan, Zijie Su, Hanbin Wang, Huan Li, Xibao Zhao, Shanshan Liu, Long Zhang, Qi Sun, Desheng Lu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract R-spondins (RSPOs) are secreted signaling molecules that potentiate the Wnt/β-catenin pathway by cooperating with Wnt ligands. RSPO1 is crucial in tissue development and tissue homeostasis. However, the molecular mechanism by which RSPOs ac
Externí odkaz:
https://doaj.org/article/d8b517d8e7034ad99dda22ae52694beb
Publikováno v:
Pharmacological Research, Vol 204, Iss , Pp 107200- (2024)
Targeting specific molecular drivers of tumor growth is a key approach in cancer therapy. Among these targets, the low-density lipoprotein receptor-related protein 6 (LRP6), a vital component of the Wnt signaling pathway, has emerged as an intriguing
Externí odkaz:
https://doaj.org/article/d1629e0a3f4a47d38db62d965f9b1a17
Autor:
Xiu Chen, Yu Zhang, Pingping Zhang, Mengzhu Wei, Tian Tian, Yanling Guan, Chenchen Han, Wei Wei, Yang Ma
Publikováno v:
Infectious Agents and Cancer, Vol 18, Iss 1, Pp 1-12 (2023)
Abstract Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive. Herein, we present ev
Externí odkaz:
https://doaj.org/article/370f299d226241e19bbc635b95e6b5fa
Akademický článek
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Akademický článek
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Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-17 (2023)
Abstract Background Mechanotransduction mechanisms whereby periodontal ligament stem cells (PDLSCs) translate mechanical stress into biochemical signals and thereby trigger osteogenic programs necessary for alveolar bone remodeling are being decipher
Externí odkaz:
https://doaj.org/article/4596ca3d9d1142f6a54e3ea40c932153
Autor:
Janine Häfliger, Marlene Schwarzfischer, Kirstin Atrott, Claudia Stanzel, Yasser Morsy, Marcin Wawrzyniak, Silvia Lang, Tomas Valenta, Konrad Basler, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 717-739 (2023)
Background & Aims: Glycoprotein (GP)96 is an endoplasmic reticulum–resident master chaperone for cell surface receptors including the Wnt co-receptors low-density lipoprotein-receptor–related protein 5/6. Intestinal epithelial cell (IEC)-specific
Externí odkaz:
https://doaj.org/article/9a20e5b0ea1a40e19da95551ede99806
Autor:
Hongya Guan, Pengju Lv, Pengli Han, Lijuan Zhou, Jia Liu, Wei Wu, Ming Yan, Qinghe Xing, Wei Cao
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 445-458 (2023)
Abstract Background Long non‐coding RNAs (lncRNAs) have critical functions within esophageal squamous cell carcinoma (ESCC). However, the function and mechanism underlying ESCC‐associated lncRNA‐1 (ESCCAL‐1) in ESCC tumorigenesis have not bee
Externí odkaz:
https://doaj.org/article/b730a94ad3c84b65bf5bb17d3b75c79b