Synthesis of new bifunctional compounds which selectively alkylate guanines in DNA

Autor: Nd, Henderson, Sm, Lacy, Hare Cc, O., Ja, Hartley, Siobhán McClean, Lp, Wakelin, Lr, Kelland, Dj, Robins

Publikováno v: Europe PubMed Central

The aim of this work was to develop new bifunctional alkylating agents which damage DNA in a selective manner. In order to extend our previously published work on conformationally restricted nitrogen mustards containing one piperidine ring, new bispi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::904ba457ec36ad6c6952407c84e018e9
https://pubmed.ncbi.nlm.nih.gov/9807160

Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening.

Autor: Drwal MN; Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia., Marinello J; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Manzo SG; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Wakelin LP; Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia., Capranico G; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Griffith R; Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia.

Publikováno v: PloS one [PLoS One] 2014 Dec 09; Vol. 9 (12), pp. e114904. Date of Electronic Publication: 2014 Dec 09 (Print Publication: 2014).

Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines.

Autor: Chen J; Department of Pharmacology, School of Medical Sciences, Wallace Wurth Building, UNSW Australia, Sydney, NSW 2052, Australia. Electronic address: junli.chen@unsw.edu.au., Campbell AP; Department of Pharmacology, School of Medical Sciences, Wallace Wurth Building, UNSW Australia, Sydney, NSW 2052, Australia. Electronic address: a.campbell@unsw.edu.au., Urmi KF; Department of Pharmacology, School of Medical Sciences, Wallace Wurth Building, UNSW Australia, Sydney, NSW 2052, Australia. Electronic address: k.urmi@unsw.edu.au., Wakelin LP; Department of Pharmacology, School of Medical Sciences, Wallace Wurth Building, UNSW Australia, Sydney, NSW 2052, Australia. Electronic address: l.wakelin@unsw.edu.au., Denny WA; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address: b.denny@auckland.ac.nz., Griffith R; Department of Pharmacology, School of Medical Sciences, Wallace Wurth Building, UNSW Australia, Sydney, NSW 2052, Australia. Electronic address: r.griffith@unsw.edu.au., Finch AM; Department of Pharmacology, School of Medical Sciences, Wallace Wurth Building, UNSW Australia, Sydney, NSW 2052, Australia. Electronic address: angela.finch@unsw.edu.au.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Nov 01; Vol. 22 (21), pp. 5910-6. Date of Electronic Publication: 2014 Sep 16.

Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells.

Autor: Wolf SJ; Biospecimens Research and Tumour Bank, Children's Cancer Research Unit, The Children's Hospital at Westmead, Westmead, NSW 2774, Australia., Huynh T, Bryce NS, Hambley TW, Wakelin LP, Stewart BW, Catchpoole DR

Publikováno v: BMC cell biology [BMC Cell Biol] 2011 Aug 24; Vol. 12, pp. 36. Date of Electronic Publication: 2011 Aug 24.

Effects of DNA minor groove binding agents on global gene expression.

Autor: Zihlif M; Department of Pharmacology, Faculty of Medicine, University of Jordan, Amman, Jordan. M.zihlif@ju.edu.jo, Catchpoole DR, Stewart BW, Wakelin LP

Publikováno v: Cancer genomics & proteomics [Cancer Genomics Proteomics] 2010 Nov-Dec; Vol. 7 (6), pp. 323-30.