Výsledky vyhledávání - "Lozan Todorov"

Akademický článek

Molecular properties of a triazole–Ce(III) complex with antioxidant activity: structure, spectroscopy, and relationships with related derivatives. Influence of the ligands in the complex

Autor: M. Alcolea Palafox, Nataliya P. Belskaya, Lozan Todorov, Nadya Hristova-Avakumova, Irena P. Kostova

Publikováno v: Frontiers in Chemistry, Vol 12 (2024)

A novel Ce(III) complex with the triazole ligand 2b, which presents four H-bonded sites with amino acids of the MMP-2 receptor, was synthesized. The experimental IR and Raman spectra of this Ce(III) complex were well-interpreted based on their compar

Externí odkaz: https://doaj.org/article/5218523dc87b448d9ad90ba190e8a8d7

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Akademický článek

1,2,3-Triazoles and their metal chelates with antimicrobial activity

Autor: Lozan Todorov, Irena Kostova

Publikováno v: Frontiers in Chemistry, Vol 11 (2023)

The emergence of drug-resistant bacterial and fungal pathogens has highlighted the urgent need of innovative antimicrobial therapeutics. Transition metal complexes with biologically active ligands (coumarins, terpyridines, triazoles, uracils, etc.) h

Externí odkaz: https://doaj.org/article/7bd960732d0c4ddeb55df600c308a27b

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Akademický článek

Does dihydropyrimidine dehydrogenase level modify plasma antioxidant capacity in colorectal cancer patients treated with fluoropyrimidines?

Autor: Velko Minchev, Nadya Hristova-Avakumova, Kalina Kamenova, Liliya Atanasova, Marin Angelov, Lozan Todorov, Slavina Surcheva, Rumen Nikolov

Publikováno v: Folia Medica, Vol 63, Iss 5, Pp 760-767 (2021)

Introduction: Colorectal cancer is the third most common cancer type worldwide. Fluoropyrimidines and their prodrug-based regimens are widely applied as primary medications. The main enzyme responsible for the rate-limiting step in pyrimidine and for

Externí odkaz: https://doaj.org/article/a876796cbb9b49189af579081ee8639a

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Akademický článek

Antioxidant Activity of Coumarins and Their Metal Complexes

Autor: Lozan Todorov, Luciano Saso, Irena Kostova

Publikováno v: Pharmaceuticals, Vol 16, Iss 5, p 651 (2023)

Ubiquitously present in plant life, coumarins, as a class of phenolic compounds, have multiple applications—in everyday life, in organic synthesis, in medicine and many others. Coumarins are well known for their broad spectrum of physiological effe

Externí odkaz: https://doaj.org/article/ed06769c596e4ac495272d4a4f32ca7a

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Akademický článek

In vitro anticancer activity and oxidative molecular damage by cannabidiol administered alone and in combination with epirubicin

Autor: Margarita Zhelyazkova, Nadya Hristova-Avakumova, Lozan Todorov, Georgi Momekov

Publikováno v: Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 1613-1622 (2021)

Evidence suggests that the non-psychotropic phytocannabinoid cannabidiol (CBD) has anticancer activity on different cell lines and in animal models. The DNA-damaging drug epirubicin (EPI) is widely used for the treatment of malignant tumours. In this

Externí odkaz: https://doaj.org/article/561a735bda53473f927a09373311a1bb

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Akademický článek

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

Autor: Lozan Todorov, Irena Kostova

Publikováno v: Molecules, Vol 28, Iss 4, p 1959 (2023)

Since the accidental discovery of the anticancer properties of cisplatin more than half a century ago, significant efforts by the broad scientific community have been and are currently being invested into the search for metal complexes with antitumor

Externí odkaz: https://doaj.org/article/4035d0b0292647b68a906d870968d445

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Akademický článek

Synthesis, Structure and Impact of 5-Aminoorotic Acid and Its Complexes with Lanthanum(III) and Gallium(III) on the Activity of Xanthine Oxidase

Autor: Lozan Todorov, Luciano Saso, Khedidja Benarous, Maria Traykova, Abderahmane Linani, Irena Kostova

Publikováno v: Molecules, Vol 26, Iss 15, p 4503 (2021)

The superoxide radical ion is involved in numerous physiological processes, associated with both health and pathology. Its participation in cancer onset and progression is well documented. Lanthanum(III) and gallium(III) are cations that are known to

Externí odkaz: https://doaj.org/article/2d7fa2545f0c4c2894059f3452cdf5b3

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