The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.

Autor: Mayer AE; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany., Löffler MC; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany., Loza Valdés AE; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany., Schmitz W; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany., El-Merahbi R; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany., Viera JT; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany., Erk M; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany., Zhang T; Biotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway., Braun U; Biotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway., Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Leitges M; Biotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway., Schulze A; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany., Sumara G; Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany. grzegorz.sumara@uni-wuerzburg.de.; Nencki Institute of Experimental Biology, PAS, 02-093 Warsaw, Poland.

Publikováno v: Science signaling [Sci Signal] 2019 Aug 06; Vol. 12 (593). Date of Electronic Publication: 2019 Aug 06.