Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Loyda M. Melendez"'
Autor:
Zaida Bayrón-Marrero, Siobhan Branfield, Javier Menéndez-Pérez, Benjamín Nieves-López, Laura Ospina, Yadira Cantres-Rosario, Loyda M. Melendez, Robert Hunter, Angelia Gibson, Gerónimo Maldonado-Martínez, A. Valance Washington
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13632 (2023)
Platelets play crucial roles in the development and progression of coronary artery disease (CAD). The triggering receptor expressed in myeloid cells-like transcript-1 (TLT-1) is stored in platelet α granules, and activated platelets release a solubl
Externí odkaz:
https://doaj.org/article/4a1029fb808d401999d8c3a4c95c0293
Autor:
Nelson Martínez-Matías, Nataliya Chorna, Sahily González-Crespo, Lilliam Villanueva, Ingrid Montes-Rodríguez, Loyda M. Melendez-Aponte, Abiel Roche-Lima, Kelvin Carrasquillo-Carrión, Ednalise Santiago-Cartagena, Brian C. Rymond, Mohan Babu, Igor Stagljar, José R. Rodríguez-Medina
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Functional analysis of the Mtl1 protein in Saccharomyces cerevisiae has revealed that this transmembrane sensor endows yeast cells with resistance to oxidative stress through a signaling mechanism called the cell wall integrity pathway (CWI)
Externí odkaz:
https://doaj.org/article/f825aad1e0eb4f1d95efe613c725f24e
Autor:
Brian C. Rymond, Sahily González-Crespo, Lilliam Villanueva, Loyda M. Melendez-Aponte, Nelson Martínez-Matías, José R. Rodríguez-Medina, Nataliya E. Chorna, Igor Stagljar, Mohan Babu, Kelvin Carrasquillo-Carrión, Ingrid M. Montes-Rodríguez, Abiel Roche-Lima, Ednalise Santiago-Cartagena
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Functional analysis of the Mtl1 protein in Saccharomyces cerevisiae has revealed that this transmembrane sensor endows yeast cells with resistance to oxidative stress through a signaling mechanism called the cell wall integrity pathway (CWI). We obse
Autor:
Omar Vélez-López, Kelvin Carrasquillo-Carrión, Yadira M. Cantres-Rosario, Eraysy Machín-Martínez, Manuel E. Álvarez-Ríos, Abiel Roche-Lima, Eduardo L. Tosado-Rodríguez, Loyda M. Meléndez
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1934 (2024)
HIV-1 infects monocyte-derived macrophages (MDM) that migrate into the brain and secrete virus and neurotoxic molecules, including cathepsin B (CATB), causing cognitive dysfunction. Cocaine potentiates CATB secretion and neurotoxicity in HIV-infected
Externí odkaz:
https://doaj.org/article/d244f6bbf6654cb6a256face6ac49479
Autor:
Lester J. Rosario-Rodríguez, Yadira M. Cantres-Rosario, Kelvin Carrasquillo-Carrión, Alexandra Rosa-Díaz, Ana E. Rodríguez-De Jesús, Verónica Rivera-Nieves, Eduardo L. Tosado-Rodríguez, Loyda B. Méndez, Abiel Roche-Lima, Jorge Bertrán, Loyda M. Meléndez
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5426 (2024)
Viral strains, age, and host factors are associated with variable immune responses against SARS-CoV-2 and disease severity. Puerto Ricans have a genetic mixture of races: European, African, and Native American. We hypothesized that unique host protei
Externí odkaz:
https://doaj.org/article/731e5c139cc4474c9267c030c130ca6f
Autor:
Lester J. Rosario-Rodríguez, Yadira M. Cantres-Rosario, Kelvin Carrasquillo-Carrión, Ana E. Rodríguez-De Jesús, Luz J. Cartagena-Isern, Luis A. García-Requena, Abiel Roche-Lima, Loyda M. Meléndez
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3246 (2024)
HIV-associated neurocognitive disorders (HAND) affect 15–55% of HIV-positive patients and effective therapies are unavailable. HIV-infected monocyte-derived macrophages (MDM) invade the brain of these individuals, promoting neurotoxicity. We demons
Externí odkaz:
https://doaj.org/article/eb0c4c893fa549a1a865cf276e77c567
Autor:
Loyda M. Melendez-Guerrero, H. Tien, Miguel A. Arroyo, Hillyer Gv, R. Swanstrom, Carmen L. Cadilla, Moraima Pagan
Publikováno v:
AIDS Research and Human Retroviruses. 18:447-460
HIV-1 vertical transmission in Puerto Rico has decreased significantly due to the implementation of antiviral therapy. Several studies have shown that the phenotype of the HIV-1 isolates initially recovered from infected infants has generally been on
Autor:
Lester J. Rosario-Rodríguez, Yamil Gerena, Luis A. García-Requena, Luz J. Cartagena-Isern, Juan C. Cuadrado-Ruiz, Gabriel Borges-Vélez, Loyda M. Meléndez
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract HIV-associated neurocognitive disorders (HAND) are prevalent despite combined antiretroviral therapy (cART), affecting 52% of people living with HIV. Our laboratory has demonstrated increased expression of cathepsin B (CATB) in postmortem br
Externí odkaz:
https://doaj.org/article/d5e8b7ab635e44b28b3468d5793a17da
Autor:
Wen-Zhe Ho, Judy W. Mikovits, Francis A. Ruscetti, Michael R. Ruff, Candace B. Pert, Loyda M. Melendez-Guerrero, Quan-en Yang
Publikováno v:
Antiviral research. 52(1)
Peptide T, which is derived from the V2 region of HIV-1, inhibits replication of R5 and dual-tropic (R5/X4) HIV-1 strains in monocyte-derived macrophages (MDMs), microglia, and primary CD4 + T cells. Little to no inhibition by peptide T was observed
Autor:
Gabriel Borges-Vélez, Juan A. Arroyo, Yadira M. Cantres-Rosario, Ana Rodriguez de Jesus, Abiel Roche-Lima, Julio Rosado-Philippi, Lester J. Rosario-Rodríguez, María S. Correa-Rivas, Maribel Campos-Rivera, Loyda M. Meléndez
Publikováno v:
Cells, Vol 11, Iss 22, p 3627 (2022)
Zika virus (ZIKV) compromises placental integrity, infecting the fetus. However, the mechanisms associated with ZIKV penetration into the placenta leading to fetal infection are unknown. Cystatin B (CSTB), the receptor for advanced glycation end prod
Externí odkaz:
https://doaj.org/article/8de32c3ba52348948485177d3113e7b3