Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Lown JW"'
Publikováno v:
Organic Letters. 4:1851-1854
[carbohydrate structure: see text] The design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates (13, 17) as DNA minor groove binding agents are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ff13c7dda9453992fc6aa80750bc2b
https://doi.org/10.1021/ol020047k
https://doi.org/10.1021/ol020047k
Publikováno v:
Biochemistry. 35:15397-15410
Five classic DNA minor groove-binding drugs and a series of bis-linked lexitropsins based on netropsin and distamycin have been screened for their effectiveness in inhibiting transcription by HIV-1 reverse transcriptase (RT) on a poly(rA).oligo(dT) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39783855cadbe6d870b4d8b0db597f2
https://doi.org/10.1021/bi961604b
https://doi.org/10.1021/bi961604b
Publikováno v:
Bioconjugate Chemistry. 7:670-679
The interaction between the cobalt(III) complex of a bleomycin functional model (AMPHIS-NET) and the oligonucleotide d(CGCAATTGCG)2 and the structural features of the 1:1 ligand-DNA complex have been determined by high-resolution two-dimensional nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b378c8b7e155c7c9ce38276502f4338a
https://doi.org/10.1021/bc960065k
https://doi.org/10.1021/bc960065k
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 12:847-855
The imidazole (Im) containing lexitropsin ImPy related to netropsin (Nt) is a sequence reading DNA ligand which, in contrast to Nt, permits binding to a GC base pair. The ImPy induced DNA conformational changes differ significantly from those induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d09bfb7258b919a660a831e59f890f
https://doi.org/10.1080/07391102.1995.10508780
https://doi.org/10.1080/07391102.1995.10508780
Publikováno v:
Biochemistry. 33:10271-10285
Two-dimensional NMR methods were used to model the possible solution structure of an intercalative complex of 9-aminoellipticine (Aell), a polycyclic pyridocarbazolamine, covalently bound to an apurinic ring-opened deoxyribose site of a duplex DNA fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c7cff09eff36c9f1dee033fff67eb6
https://doi.org/10.1021/bi00200a007
https://doi.org/10.1021/bi00200a007
Autor:
D Mrani, Raymond Houssin, Lown Jw, Jean Louis Imbach, Pierre Colson, Claude Houssier, Michael J. Waring, Jean-Pierre Hénichart, Gilles Gosselin, Christian Bailly
Publikováno v:
Biochemistry. 31:8349-8362
We report the DNA binding properties of two hybrid molecules which result from the combination of the DNA sequence-specific minor groove ligand netropsin with the bithiazole moiety of the antitumor drug bleomycin. The drug-DNA interaction has been in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a9ab559cabb71375fc8c9c4a6559c3
https://doi.org/10.1021/bi00150a032
https://doi.org/10.1021/bi00150a032
Autor:
R. Houssin, Jean Louis Imbach, Jan Balzarini, K. E. Rao, Christian Bailly, D Mrani, Gilles Gosselin, J.P. Hénichart, J. Zimmermann, Lown Jw, E. De Clercq
Publikováno v:
European Journal of Medicinal Chemistry. 27:331-344
A series of hybrid molecules have been synthesized which result from the combination of a DNA sequence-specific ligand (netropsin) coupled to a DNA-interactive structural component of bleomycins (bithiazole). The DNA binding affinities as well as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66f7f59e9ebd739b80f19409ffe79d1
https://doi.org/10.1016/0223-5234(92)90146-r
https://doi.org/10.1016/0223-5234(92)90146-r
Autor:
Lown Jw
Publikováno v:
Antiviral Research. 17:179-196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99f363c3dad01e62b4acc8a27135ad5
https://doi.org/10.1016/0166-3542(92)90040-c
https://doi.org/10.1016/0166-3542(92)90040-c
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 9:299-313
Ab initio calculations (Hartree-Fock) using the 6-31 G basis set have been performed on two prototype lexitropsins or information-reading molecules. The latter are DNA minor groove binding agents related to the A.T recognizing netropsin in which each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ee3aee8bb6b2c355cae076edeb99ac
https://doi.org/10.1080/07391102.1991.10507914
https://doi.org/10.1080/07391102.1991.10507914
Autor:
Lown Jw, Rayner B, William H. Gmeiner, Jean Louis Imbach, Jean-Jacques Vasseur, François Morvan, Rao Ke
Publikováno v:
Biochemistry. 29:10329-10341
The novel hybrid duplex alpha-5'-d(TACACA)-3'.beta-5'-r(AUGUGU)-3' was analyzed extensively by 1D and 2D NMR methods. Two forms of the duplex exist in about an 80:20 ratio. Analysis of the exchangeable imino protons of the major component revealed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede538cc0c7d04933a5e7a4232215616
https://doi.org/10.1021/bi00497a007
https://doi.org/10.1021/bi00497a007