Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism

Autor: Kim Moorwood, Florentia M. Smith, Alastair S. Garfield, Michael Cowley, Lowenna J. Holt, Roger J. Daly, Andrew Ward

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-22 (2024)

Abstract Background The growth factor receptor bound protein 7 (Grb7) family of signalling adaptor proteins comprises Grb7, Grb10 and Grb14. Each can interact with the insulin receptor and other receptor tyrosine kinases, where Grb10 and Grb14 inhibi

Externí odkaz: https://doaj.org/article/4301b2953b36487aa2e022180b9e1406

Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice

Autor: Chantal A. Coles, Elaine Preston, Roger J. Daly, Lewin Small, Eurwin Suryana, Donna Wilks, Nancy Mokbel, Gregory J. Cooney, Amanda E. Brandon, Lowenna J Holt, Jason D. White, Nigel Turner

Publikováno v: Endocrinology. 159(3)

Grb10 is an adaptor-type signaling protein most highly expressed in tissues involved in insulin action and glucose metabolism, such as muscle, pancreas, and adipose. Germline deletion of Grb10 in mice creates a phenotype with larger muscles and impro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169edab31ba04a0158dfe81a3faac398
https://pubmed.ncbi.nlm.nih.gov/29370381

Growth Factor Receptor-Bound Protein 14 Undergoes Light-Dependent Intracellular Translocation in Rod Photoreceptors: Functional Role in Retinal Insulin Receptor Activation

Autor: Dustin T. Allen, Ammaji Rajala, Roger J. Daly, Vadim Y. Arshavsky, Raju V. S. Rajala, Masaki Tanito, Ekaterina S. Lobanova, Lowenna J Holt

Publikováno v: Biochemistry. 48:5563-5572

Phosphoinositide 3-kinase kinase (PI3K) is at the heart of one of the major signal transduction pathways (1–4). The signals mediated by this enzyme influence a wide variety of cellular functions, including cell growth, differentiation and survival,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b654aa5a2dd4bbb68e69d9024c6922a
https://doi.org/10.1021/bi9000062

Hydrophilic and cationic latex particles for the specific extraction of nucleic acids

Autor: Cécile Voisset, Abdelhamid Elaissari, Claude Mabilat, Christian Pichot, Francoise Meunier, Bernard Mandrand, Lowenna J Holt

Publikováno v: Journal of Biomaterials Science, Polymer Edition
Journal of Biomaterials Science, Polymer Edition, Taylor & Francis, 1999, 10 (4), pp.403-420. ⟨10.1163/156856299X00171⟩

The adsorption of BSA and RNA onto hydrophilic and thermosensitive poly(N-isopropyl-acrylamide) (NIPAM) latex particles was described as a function of pH, ionic strength and temperature. The hydrogel poly(NIPAM) latex was synthesized by precipitation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bbf19935a6d0cd2fe797ae867ec5dd
https://doi.org/10.1163/156856299x00171

Grb10 regulates the development of fiber number in skeletal muscle

Autor: Nancy Mokbel, Roger J. Daly, Sophie Trefely, Lowenna J Holt, Christopher J. Ormandy, Warren Kaplan, Timo Kanzleiter, Gregory J. Cooney, Nigel Turner

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(9)

Grb10 is an intracellular adaptor protein that acts as a negative regulator of insulin and insulin-like growth factor 1 (IGF1) receptors. Since global deletion of Grb10 in mice causes hypermuscularity, we have characterized the skeletal muscle physio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecceaa274f158ddcfa6940d1cd51e804
https://pubmed.ncbi.nlm.nih.gov/22623587