Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lowell J. Underwood"'
Autor:
Timothy J. O'Brien, John B. Beard, Lowell J. Underwood, Alessandro D. Santin, Lyndal York, Richard A. Dennis
Publikováno v:
Tumor Biology. 22:348-366
CA 125 has long presented problems to both clinicians and investigators because there was no definitive information on its structure and function. Here, we describe our work on cloning the CA 125 gene with the anticipation that such information will
Autor:
Yinxiang Wang, Lowell J. Underwood, Hirotoshi Tanimoto, Timothy J. O'Brien, Tim H. Parmley, Kazushi Shigemasa
Publikováno v:
Tumor Biology. 22:104-114
Proteases have been implicated in the extracellular modulation required for tumor growth and invasion. In an effort to categorize those proteases contributing to ovarian carcinoma progression, we have utilized redundant primers to conserved amino aci
Autor:
Timothy J. O'Brien, Kazushi Shigemasa, Lowell J. Underwood, Hirotoshi Tanimoto, Tim H. Parmley, Koso Ohama, John B. Beard
Publikováno v:
Journal of the Society for Gynecologic Investigation. 7:358-362
Objective:In a continued effort to identify and characterized secreted proteases that are overexpressed in ovarian carcinomas, we discovered the testisin protease as such a candidate. When this dis...
Autor:
Janet Osborne, Timothy J. O'Brien, C. Hu, Colleen Hawley, Lowell J. Underwood, Vicki V. Baker
Publikováno v:
Journal of the Society for Gynecologic Investigation. 5:277-280
OBJECTIVE Hox genes encode DNA transcription regulatory proteins that contain a conserved 61 amino acid protein called the homeodomain. Although best known for their role in cellular differentiation during embryonic development, aberrant expression o
Autor:
Lowell J. Underwood, Koso Ohama, Lijun Gu, Xiurong Tian, Kazushi Shigemasa, Hirotoshi Tanimoto, Timothy J. O'Brien
Publikováno v:
Oncology reports. 11(6)
The purpose of this study was to examine human kallikrein 8 (hK8/TADG-14) expression in epithelial ovarian tumors and to investigate the association of hK8 expression levels with patient survival. Human kallikrein 8 protein (hK8) expression was exami
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 23(3)
CA 125 is a well-established marker for patients diagnosed with ovarian carcinoma. It is clearly elaborated in serous cystadenocarcinomas and less likely to be expressed in mucinous tumors. It has been 20 years since CA 125 was first recognized and i
Autor:
Timothy J. O'Brien, Tim H. Parmley, Kazushi Shigemasa, Hirotoshi Tanimoto, Koji Arihiro, Lowell J. Underwood, Koso Ohama
Publikováno v:
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 11(6)
We have previously reported that the stratum corneum chymotryptic enzyme (SCCE) is overexpressed in ovarian cancers and that SCCE has potential as a useful marker and/or a therapeutic target for ovarian carcinoma. Antileukoprotease (ALP) has been sho
Autor:
Yinxiang Wang, Kazushi Shigemasa, Timothy J. O'Brien, Elizabeth Nestrud Schneider, Hirotoshi Tanimoto, John B. Beard, Tim H. Parmley, Lowell J. Underwood
Publikováno v:
Biochimica et biophysica acta. 1502(3)
Serine proteases serve many functions in normal biological processes. These functions are often usurped by cancer cells to allow progression of tumors by increasing the growth and metastatic potential of the neoplasia. Here, we have used a polymerase
Autor:
Timothy J. O'Brien, Kazushi Shigemasa, Hirotoshi Tanimoto, Tim H. Parmley, Lowell J. Underwood
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 22(1)
Proteases are known to play important roles in tumor invasion and metastasis. Protease M, which was originally identified by Anisowicz and colleagues in 1996, is a new member of the serine protease family. We also identified the protease M transcript
Autor:
Yan Yan, Hirotoshi Tanimoto, Yinxiang Wang, Kazushi Shigemasa, Timothy J. O'Brien, Lowell J. Underwood, John Clarke, Tim H. Parmley
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 20(2)
Matrix metalloproteases are known to play an important role in tumor invasion by mediating degradation of extracellular matrix. In this study, we have investigated the expression of the matrix metalloprotease pump-1 gene (also referred to as MMP-7, M