Zobrazeno 1 - 10
of 408
pro vyhledávání: '"Low-density lipoprotein receptor gene family"'
Autor:
Saito, Akihiko, Yamazaki, Hajime, Rader, Katherine, Nakatani, Akiko, Ullrich, Robert, Kerjaschki, Dontscho, Orlando, Robert A., Farquhar, Marilyn Gist
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1996 Aug 01. 93(16), 8601-8605.
Externí odkaz:
https://www.jstor.org/stable/39910
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1995 Aug . 92(18), 8453-8457.
Externí odkaz:
https://www.jstor.org/stable/2368076
Publikováno v:
Current Opinion in Lipidology. 28(3):241-247
Purpose of review Clearing of atherogenic lipoprotein particles by the liver requires hepatic low-density lipoprotein receptor (LDLR) and LDLR-related protein 1 (LRP1). This review highlights recent studies that have expanded our understanding of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a130cc36ac9036e7aee1119c9f8060
https://hdl.handle.net/11370/9b7ed149-be14-42f6-a6fd-f5a6e350b918
https://hdl.handle.net/11370/9b7ed149-be14-42f6-a6fd-f5a6e350b918
Autor:
Courtney Lane-Donovan, Joachim Herz
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1036-1043 (2017)
The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0779cd6a8f79b5f10a9660ffe7b61245
https://doi.org/10.1194/jlr.r075507
https://doi.org/10.1194/jlr.r075507
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 2, Pp 364-374 (2017)
Lipoproteins internalized by the LDL receptor (LDLR) are released from this receptor in endosomes through a process that involves acid-dependent conformational changes in the receptor ectodomain. How acidic pH promotes this release process is not wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15a8f38223a433cdbf6957b26a7d9c7
https://doi.org/10.1194/jlr.m070938
https://doi.org/10.1194/jlr.m070938
Autor:
J. Olsen, Elisabeth Veyhe Andersen, Peter Tougaard, Gorm Thorlacius Ussing, Anders Elm Pedersen, Brian Skriver Nielsen
Publikováno v:
Global Journal of Gastroenterology & Hepatology. 4:36-44
Background and Aim : Chronic inflammation is associated with changes in lipid and cholesterol metabolism in the liver. A predominant finding is changes in surface LDL receptor (LDLR) expression at various stages of disease which may be associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8283252ce8035674550977c699299f93
https://doi.org/10.12970/2308-6483.2016.04.02.3
https://doi.org/10.12970/2308-6483.2016.04.02.3
Autor:
Nabil G. Seidah
Publikováno v:
Current Opinion in Lipidology. 27:274-281
High levels of LDL-cholesterol (LDL-C) are directly associated with devastating cardiovascular complications. Statins downregulate cholesterol synthesis and upregulate hepatic mRNA levels of LDL receptor (LDLR) and proprotein convertase subtilisin-ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c89f561380536b0ef1246790594b5c
https://doi.org/10.1097/mol.0000000000000295
https://doi.org/10.1097/mol.0000000000000295
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) regulates the expression of low-density lipoprotein (LDL)-receptors, through reducing their recycling by binding to the receptor along with LDL and targeting it for lysosomal destruction. PCSK9 al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bcc3d3edcae546032faf61eb3902333
https://doi.org/10.1016/j.atherosclerosis.2016.02.018
https://doi.org/10.1016/j.atherosclerosis.2016.02.018
Autor:
Henri J. Huttunen, Kai Kysenius
Publikováno v:
Experimental Cell Research. 340:238-247
Lipoprotein receptor family members hold multiple roles in the brain, and alterations in lipoprotein receptor expression and function are implicated in neuronal stress, developmental disorders and neurodegenerative diseases, such as Alzheimer's disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4a5cbc577fc0ff9b08d494cb5ffc53
https://doi.org/10.1016/j.yexcr.2016.01.001
https://doi.org/10.1016/j.yexcr.2016.01.001
Publikováno v:
Biochemical Journal. 472:275-286
The hepatic expression of low-density lipoprotein (LDL) receptor (LDLR) gene is regulated primarily at the transcriptional level by a sterol-regulatory element (SRE) in its proximal promoter region which is the site of action of SRE-binding protein 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e916f7a721687e24a6fd1fbe2c5a82c
https://doi.org/10.1042/bj20150666
https://doi.org/10.1042/bj20150666