Zobrazeno 1 - 10
of 2 829
pro vyhledávání: '"Low Density Lipoprotein Receptor –Related Protein"'
Autor:
Lucia Soria-Tobar, Laura Román-Valero, Álvaro Sebastián-Serrano, Paloma Aivar, Beatriz Álvarez-Castelao, Miguel Díaz-Hernández
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. Three new drugs for AD based on monoclonal antibodies against the amyloid-β peptide (Aβ) have recently been approved because they favor the reduction of
Externí odkaz:
https://doaj.org/article/03f850d954664ef7a6519c138f55e3c5
Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier
Autor:
Laura Fritzen, Katharina Wienken, Lelia Wagner, Magdalena Kurtyka, Katharina Vogel, Jakob Körbelin, Sascha Weggen, Gert Fricker, Claus U. Pietrzik
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-23 (2024)
Abstract Background The most crucial area to focus on when thinking of novel pathways for drug delivery into the CNS is the blood brain barrier (BBB). A number of nanoparticulate formulations have been shown in earlier research to target receptors at
Externí odkaz:
https://doaj.org/article/6959b746fc7b4f43abec3dada8978c0c
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Background MiRNAs are closely related to tumor radiosensitivity. MiR-378a-5p level is down-regulated in colorectal cancer (CRC). Therefore, this study intends to explore the role of miR-378a-5p in CRC, especially radiosensitivity.Methods The expressi
Externí odkaz:
https://doaj.org/article/e21f3be6208d4700b105da22cde11d14
Autor:
Yiyan Zhao, Weimin Liu, Xiaoming Zhao, Zhitao Yu, Hongfang Guo, Yang Yang, Hans Merzendorfer, Kun Yan Zhu, Jianzhen Zhang
Publikováno v:
Journal of Integrative Agriculture, Vol 23, Iss 5, Pp 1618-1633 (2024)
Low-density lipoprotein receptor-related protein 2 (LRP2) is a multifunctional endocytic receptor expressed in epithelial cells. In mammals, it acts as an endocytic receptor that mediates the cellular uptake of cholesterol-containing apolipoproteins
Externí odkaz:
https://doaj.org/article/9b3da2b555bd45f7a3530630add234a7
Publikováno v:
Radiology Case Reports, Vol 19, Iss 4, Pp 1325-1328 (2024)
Osteopetrosis is a heterogenous group of inheritable disorders which manifests as increased bone density and brittleness. The most common and mildest variant typically presents in adulthood with bone pain and pathologic fractures, including spondylol
Externí odkaz:
https://doaj.org/article/2cf168c6adc14e089e250f333ed14b26
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 3, Pp 695-714 (2023)
Alzheimer’s disease, the primary cause of dementia, is characterized by neuropathologies, such as amyloid plaques, synaptic and neuronal degeneration, and neurofibrillary tangles. Although amyloid plaques are the primary characteristic of Alzheimer
Externí odkaz:
https://doaj.org/article/548fec7ed7264a1f9707fc01ec234d71
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Lead (Pb) is a known environmental risk factor in the etiology of Alzheimer’s disease (AD). The existing reports suggest that Pb exposure increases beta-amyloid (Aβ) levels in brain tissues and cerebrospinal fluid (CSF) and facilitates th
Externí odkaz:
https://doaj.org/article/8588a97d8e634cb49f6ac1046875181f
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Osteoporosis is a systemic bone disease characterized by an imbalance in the relationship between osteoblasts, osteocytes, and osteoclasts. This imbalance in bone metabolism results in the destruction of the bone’s microstructure and an increase in
Externí odkaz:
https://doaj.org/article/32a8c2ee4b1d45f9a83c3049a0f64aa1
Publikováno v:
Orthopedic Research and Reviews, Vol Volume 15, Pp 39-45 (2023)
Jake Littman,1 Chanika Phornphutkul,2 Celine Saade,3 Julia Katarincic,1 Roy Aaron1 1Department of Orthopedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI, USA; 2Division of Human Genetics, Department of Pediatrics, Hasbro
Externí odkaz:
https://doaj.org/article/ff326069353b4e159eac1443db412b08
Autor:
Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lazarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien, Carine Ali
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background In the vascular compartment, the serine protease tissue-type plasminogen activator (tPA) promotes fibrinolysis, justifying its clinical use against vasculo-occlusive diseases. Accumulating evidence shows that circulating tPA (endo
Externí odkaz:
https://doaj.org/article/60012a27b2ab46b7a5e1d372421d5ee8