Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lovisa Dousha"'
Autor:
Paul T. King, Lovisa Dousha, Nadeene Clarke, Jennifer Schaefer, Rosemary Carzino, Roleen Sharma, Ken L. Wan, Aveena Anantharajah, Kim O'Sullivan, Zhong X. Lu, Stephen R. Holdsworth, Sarath Ranganathan, Philip G. Bardin, David S. Armstrong
Publikováno v:
ERJ Open Research, Vol 7, Iss 2 (2021)
Childhood lung infection is often associated with prominent neutrophilic airway inflammation and excess production of proteases such as neutrophil elastase (NE). The mechanisms responsible for this inflammation are not well understood. One potentiall
Externí odkaz:
https://doaj.org/article/117403dc98d74041be104999276d522c
Autor:
Andrew Lilja, Clare E Weeden, Kate McArthur, Thao Nguyen, Alastair Donald, Zi Xin Wong, Lovisa Dousha, Steve Bozinovski, Ross Vlahos, Christopher J Burns, Marie-Liesse Asselin-Labat, Gary P Anderson
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0114975 (2015)
Inflammation is an important component of cancer diathesis and treatment-refractory inflammation is a feature of many chronic degenerative lung diseases. HSP90 is a 90kDa protein which functions as an ATP-dependent molecular chaperone that regulates
Externí odkaz:
https://doaj.org/article/cb1257f818d240afaad8c2a8edb75f39
Autor:
Stephen R. Holdsworth, Philip G. Bardin, Nadeene Clarke, Ken L. Wan, Zhong X. Lu, David S. Armstrong, Roleen Sharma, Jennifer Schaefer, Paul T. King, Rosemary Carzino, Sarath Ranganathan, Kim M. O’Sullivan, Aveena Anantharajah, Lovisa Dousha
Publikováno v:
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 2 (2021)
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 2 (2021)
Childhood lung infection is often associated with prominent neutrophilic airway inflammation and excess production of proteases such as neutrophil elastase (NE). The mechanisms responsible for this inflammation are not well understood. One potentiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f6ecb8c761539ff51c3635e0961ad7
https://doi.org/10.1183/23120541.00883-2020
https://doi.org/10.1183/23120541.00883-2020
Publikováno v:
Airway cell biology and immunopathology.
1. Precision cut lung slices (PCLS) offer a unique integrated experimental platform for investigating both inflammatory and immune responses to viral infection. 2. This study aimed to develop a protocol for robust infection of PCLS ex vivo with influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ef24d672e66b19d2de65f798b4650e
https://doi.org/10.1183/13993003.congress-2021.pa3691
https://doi.org/10.1183/13993003.congress-2021.pa3691
Publikováno v:
Journal of visualized experiments : JoVE. (172)
Haemophilus influenzae (Hi) is a prevalent bacterium found in a range of respiratory conditions. A variety of different assays/techniques may be used to assess the respiratory immune/inflammatory response to this bacterium. Flow cytometry and confoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e2e5f929f2a658cf668b6bba1107e13
https://pubmed.ncbi.nlm.nih.gov/34279491
https://pubmed.ncbi.nlm.nih.gov/34279491
Publikováno v:
Journal of Visualized Experiments.
Haemophilus influenzae (Hi) is a prevalent bacterium found in a range of respiratory conditions. A variety of different assays/techniques may be used to assess the respiratory immune/inflammatory response to this bacterium. Flow cytometry and confoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944d04212baf0a9a6ec46a33049358cd
https://doi.org/10.3791/62572-v
https://doi.org/10.3791/62572-v
Autor:
Saleela Ruwanpura, Paul T. King, Kim M. O’Sullivan, Belinda J. Thomas, Lovisa Dousha, Judy M. Callaghan, Stavros Selemidis, Roleen Sharma, Gavin De Carle Brooks, Michael Farmer, Michaela Finsterbusch, Gary P. Anderson, Barton R Jennings, Steven Lim, Philip G. Bardin, Stephen R. Holdsworth
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Our aim was to investigate if deoxyribonuclease (DNase) 1 is a potential therapeutic agent to reduce pathogenic effects of cigarette smoke exposure in the lung. Cigarette smoke causes protease imbalance with excess production of proteases, which is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4853588de49460d7e8e01050b6da1d4f
https://doi.org/10.1038/s41598-017-12474-5
https://doi.org/10.1038/s41598-017-12474-5
Autor:
Virginie Deswaerte, Lovisa Dousha, Christoph Garbers, Huei Jiunn Seow, Martin MacDonald, Louise McLeod, Gary P. Anderson, Stefan Rose-John, Philip G. Bardin, Michelle D. Tate, Sultan Alhayyani, Ross Vlahos, Paul T. King, Steven Bozinovski, Brendan J. Jenkins, Saleela Ruwanpura, Gavin De Carle Brooks
Publikováno v:
American journal of respiratory and critical care medicine. 194(12)
The potent immunomodulatory cytokine IL-6 is consistently up-regulated in human lungs with emphysema and in mouse emphysema models; however, the mechanisms by which IL-6 promotes emphysema remain obscure. IL-6 signals using two distinct modes: classi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd32e9a10fd1c850fbf171e1d620ccc
https://pubmed.ncbi.nlm.nih.gov/27976936
https://pubmed.ncbi.nlm.nih.gov/27976936
Autor:
Gary P. Anderson, Sheau Pyng J. Chan, Ross Vlahos, Huei Jiunn Seow, Selcuk Yatmaz, Shenna Y. Langenbach, Lovisa Dousha, Steven Bozinovski, Michelle J. Hansen, Jessica E Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 11, p e113180 (2014)
PLoS ONE, Vol 9, Iss 11, p e113180 (2014)
While global success in cessation advocacy has seen smoking rates fall in many developed countries, persistent lung inflammation in ex-smokers is an increasingly important clinical problem whose mechanistic basis remains poorly understood. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1269654e51ec5c970ce42ce291dba1
https://pubmed.ncbi.nlm.nih.gov/25405776
https://pubmed.ncbi.nlm.nih.gov/25405776
Autor:
Huei Jiunn Seow, Gary P. Anderson, Lovisa Dousha, Bruce D. Levy, Mohib Uddin, Ross Vlahos, Louis Irving, Steven Bozinovski, Michelle E. Thompson, Desiree Anthony
Publikováno v:
American journal of respiratory and critical care medicine. 188(2)
Neutrophilic inflammation is an important pathologic feature of chronic obstructive pulmonary disease (COPD) and infectious exacerbations of COPD. Serum amyloid A (SAA) promotes neutrophilic inflammation by its interaction with lung mucosal ALX/FPR2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fa7efa86226c01ebfa364d33285d4a
https://pubmed.ncbi.nlm.nih.gov/23627303
https://pubmed.ncbi.nlm.nih.gov/23627303