Výsledky vyhledávání - "Love, Sharma"

Akademický článek

Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy[S]

Autor: Ashraf U. Nissar, Love Sharma, Malik A. Mudasir, Lone A. Nazir, Sheikh A. Umar, Parduman R. Sharma, Ram A. Vishwakarma, Sheikh A. Tasduq

Publikováno v: Journal of Lipid Research, Vol 58, Iss 9, Pp 1855-1868 (2017)

Defective autophagy has been linked to lipotoxicity in several cellular models. We aimed to investigate autophagy in lipid-stimulated hepatoma (Huh7) cells and tested whether 4-phenyl butyric acid (4-PBA), a chemical chaperone, has a beneficial role

Externí odkaz: https://doaj.org/article/cb81a8799fcc4ae0a5aabeb979c3ae0d

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Thioacetamide potentiates high cholesterol and high fat diet induced steato-hepatitic changes in livers of C57BL/6J mice: A novel eight weeks model of fibrosing NASH

Autor: Divya Gupta, Love Sharma, Sheikh Tasduq Abdullah

Publikováno v: Toxicology Letters. 304:21-29

There is an inadequacy of relevant animal models to study non-alcoholic steatohepatitis (NASH) and fibrosis. Here, we co-administered thioacetamide (TH) along with fast food diet (FFD) to C57BL/6 J mice for eight weeks. The treatments were: a) standa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c2cc85abbb7f4923a77acffe2a26ba
https://doi.org/10.1016/j.toxlet.2019.01.001

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Akademický článek

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Acteoside-mediates chemoprevention of experimental liver carcinogenesis through STAT-3 regulated oxidative stress and apoptosis

Autor: Love Sharma, Naresh Kumar Satti, Bhushan Shashi, Sheikh A. Tasduq, Aamir H. Faridi, Kaiser J. Peerzada, Subhash Bhardwaj

Publikováno v: Environmental Toxicology. 31:782-798

In the absence of an effective therapy against Hepatocellular Carcinoma (HCC), chemoprevention remains an important strategy to circumvent morbidity and mortality. Here, we examined chemopreventive potential of Acteoside (ACT), a plant derived phenyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b734b176aeed3f55cf258036e88feade
https://doi.org/10.1002/tox.22089

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Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL/6J mice, via restoration of hepatic autophagy

Autor: Adil Hassan, Love Sharma, Tasduq S Abdullah, Nazir A. Lone, Rachel M. Knott

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 121

Non-alcoholic fatty liver disease (NAFLD) is often linked with impaired hepatic autophagy. Here, we studied the alterations in hepatocellular autophagy by high cholesterol and high-fat diet (HC-HF) diet in C57BL/6J mice, and by palmitic acid (PA), in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7bec4b340ca5a9fa1d1088564f96cf
https://pubmed.ncbi.nlm.nih.gov/30208301

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Palmitic acid induced lipotoxicity is associated with altered lipid metabolism, enhanced CYP450 2E1 and intracellular calcium mediated ER stress in human hepatoma cells

Autor: Ashraf U. Nissar, Sheikh A. Tasduq, Love Sharma

Publikováno v: Toxicology Research. 4:1344-1358

The aim of the present investigation was to study the events associated with palmitic acid induced metabolic and lipotoxic changes in human hepatoma cells (Hep3B, Huh7 and HepG2). The cells were lipid-overloaded with varied concentrations of saturate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4beb8b32596823fa47229f0617e9421
https://doi.org/10.1039/c5tx00101c

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Synthesis, characterization and augmented anticancer potential of PEG-betulinic acid conjugate

Autor: Ravindra Dhar Dubey, P. L. Sangwan, Ankit Saneja, Dilip M. Mondhe, Sheikh Abdullah Tasaduq, Mubashir Javed Mintoo, Love Sharma, Amit Kumar, Prem N. Gupta, Gurdarshan Singh, Amrinder Singh

Publikováno v: Materials scienceengineering. C, Materials for biological applications. 73

Betulinic acid (BA), a pentacyclic lupine-type triterpene, is reported to inhibit cell growth in a variety of cancers. However, its efficacy is limited by its poor aqueous solubility and relatively short half-life. In this study, BA-monomethoxy polye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eda25f363be671e2fdece068a13a51b
https://pubmed.ncbi.nlm.nih.gov/28183653

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