Solid state 13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery system

Autor: McCoy, Clare F., Apperley, David C., Malcolm, Robert, Variano, Bruce, Sussman, Heather, Louven, Daniel, Boyd, Peter, Malcolm, R. Karl

Publikováno v: McCoy, C F, Apperley, D C, Malcolm, R, Variano, B, Sussman, H, Louven, D, Boyd, P & Malcolm, R K 2018, ' Solid state 13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery system ', International Journal of Pharmaceutics, vol. 548, 10.1016/j.ijpharm.2018.07.040, pp. 689-697 . https://doi.org/10.1016/j.ijpharm.2018.07.040

Steroid molecules have a long history of incorporation into silicone elastomer materials for controlled release drug delivery applications. Previously, based on in vitro release testing and drug content analysis, we demonstrated indirectly that the c

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https://pure.qub.ac.uk/en/publications/fe5f23bb-19a5-499d-9b91-c98cc10975cf