Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain

Autor: Assia Mouhand, Loussiné Zargarian, Anissa Belfetmi, Marjorie Catala, Marco Pasi, Ewen Lescop, Carine Tisné, Olivier Mauffret

Publikováno v: Viruses, Vol 14, Iss 3, p 632 (2022)

The nucleocapsid domain (NCd), located at the C-terminus of the HIV-1 Gag protein, is involved in numerous stages of the replication cycle, such as the packaging of the viral genome and reverse transcription. It exists under different forms through t

Externí odkaz: https://doaj.org/article/627b846bf9ec4dfa9a79b6d94dc977b4

Studies of the antitumor mechanism of action of dermaseptin B2, a multifunctional cationic antimicrobial peptide, reveal a partial implication of cell surface glycosaminoglycans.

Autor: Célia Dos Santos, Sabah Hamadat, Karen Le Saux, Clara Newton, Meriem Mazouni, Loussiné Zargarian, Mickael Miro-Padovani, Patricia Zadigue, Jean Delbé, Yamina Hamma-Kourbali, Mohamed Amiche

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182926 (2017)

Dermaseptin-B2 (DRS-B2) is a multifunctional cationic antimicrobial peptide (CAP) isolated from frog skin secretion. We previously reported that DRS-B2 possesses anticancer and antiangiogenic activities in vitro and in vivo. In the present study, we

Externí odkaz: https://doaj.org/article/3b02bf40888a4211bad00eaf50f6d847

Intrinsic nucleic acid dynamics modulates HIV-1 nucleocapsid protein binding to its targets.

Autor: Ali Bazzi, Loussiné Zargarian, Françoise Chaminade, Hugues De Rocquigny, Brigitte René, Yves Mély, Philippe Fossé, Olivier Mauffret

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38905 (2012)

HIV-1 nucleocapsid protein (NC) is involved in the rearrangement of nucleic acids occurring in key steps of reverse transcription. The protein, through its two zinc fingers, interacts preferentially with unpaired guanines in single-stranded sequences

Externí odkaz: https://doaj.org/article/4daf88b01b9443528384150c085154af

The intrinsic mechanics of B-DNA in solution characterized by NMR

Autor: Akli Ben Imeddourene, Xiaoqian Xu, Christophe Oguey, Brigitte Hartmann, Loussiné Zargarian, Nicolas Foloppe, Olivier Mauffret

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2016, 44 (7), pp.3432-3447. ⟨10.1093/nar/gkw084⟩
Nucleic Acids Research, 2016, 44 (7), pp.3432-3447. ⟨10.1093/nar/gkw084⟩

International audience; Experimental characterization of the structural couplings in free B-DNA in solution has been elusive, because of subtle effects that are challenging to tackle. Here, the exploitation of the NMR measurements collected on four d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31068f6be868b397b09a014589517dce
http://europepmc.org/articles/PMC4838374

Structural and Dynamical Impact of a Universal Fluorescent Nucleoside Analogue Inserted Into a DNA Duplex

Autor: Nelly Morellet, Loussiné Zargarian, Olivier Mauffret, Yves Mély, Brigitte René, Nicolas Barthes, Krishna Gavvala, Alain Burger, Akli Ben Imeddourene, Benoît Y. Michel, Philippe Fosse, Cyril A. Kenfack

Publikováno v: Journal of Physical Chemistry B
Journal of Physical Chemistry B, American Chemical Society, 2017, 121 (50), pp.11249-11261. ⟨10.1021/acs.jpcb.7b08825⟩
Journal of Physical Chemistry B, 2017, 121 (50), pp.11249-11261. ⟨10.1021/acs.jpcb.7b08825⟩

Recently, a 3-hydroxychromone based nucleoside 3HCnt has been developed as a highly environment-sensitive nucleoside surrogate to investigate protein-DNA interactions. When it is incorporated in DNA, the probe is up to 50-fold brighter than 2-aminopu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4e8c048af6cbb96e1c329c68cfcb6c
https://hal.archives-ouvertes.fr/hal-02119010