Výsledky vyhledávání - "Lourens J. P. Nonkes"

Akademický článek

Automatic quantification of lymphocyte vacuolization in peripheral blood smears of patients with Batten's disease (CLN3 disease)

Autor: Lourens J. P. Nonkes, Willemijn F. E. Kuper, Karin Berrens‐Hogenbirk, Ruben E. A. Musson, Peter M. vanHasselt, Albert Huisman

Publikováno v: JIMD Reports, Vol 58, Iss 1, Pp 100-103 (2021)

Abstract Quantifying lymphocyte vacuolization in peripheral blood smears (PBSs) serves as a measure for disease severity in CLN3 disease—a lysosomal storage disorder of childhood‐onset. However, thus far quantification methods are based on labor�

Externí odkaz: https://doaj.org/article/43aeac3783594367870bdff0c67e8d25

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Akademický článek

Quantifying lymphocyte vacuolization serves as a measure of CLN3 disease severity

Autor: Willemijn F. E. Kuper, Marlies Oostendorp, Brigitte T. A. van den Broek, Karin van Veghel, Lourens J. P. Nonkes, Edward E. S. Nieuwenhuis, Sabine A. Fuchs, Tineke Veenendaal, Judith Klumperman, Albert Huisman, Stefan Nierkens, Peter M. van Hasselt

Publikováno v: JIMD Reports, Vol 54, Iss 1, Pp 87-97 (2020)

Abstract Background The CLN3 disease spectrum ranges from a childhood‐onset neurodegenerative disorder to a retina‐only disease. Given the lack of metabolic disease severity markers, it may be difficult to provide adequate counseling, particularl

Externí odkaz: https://doaj.org/article/7886a21647e344d2b4f69eb6634c1ae8

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Temporally precise control of single-neuron spiking by juxtacellular nanostimulation

Autor: Lourens J. P. Nonkes, Paul H. E. Tiesinga, H. Rüdiger A. P. Geis, Arthur R. Houweling, Maik C. Stüttgen

Publikováno v: Journal of Neurophysiology, 117(3), 1363-1378. American Physiological Society
Journal of Neurophysiology, 117, 3, pp. 1363-1378
Journal of Neurophysiology, 117, 1363-1378
Journal of neurophysiology 117(3), 1363-1378 (2017). doi:10.1152/jn.00479.2016

Temporal patterns of action potentials influence a variety of activity-dependent intra- and intercellular processes and play an important role in theories of neural coding. Elucidating the mechanisms underlying these phenomena requires imposing spike

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9743d8e76de315cb20e62f7db788359b
https://doi.org/10.1152/jn.00479.2016

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Improved cognitive flexibility in serotonin transporter knockout rats is unchanged following chronic cocaine self-administration

Autor: Lourens J P, Nonkes, Joseph H R, Maes, Judith R, Homberg

Publikováno v: Addiction biology. 18(3)

Cocaine dependence is associated with orbitofrontal cortex (OFC)-dependent cognitive inflexibility in both humans and laboratory animals. A critical question is whether cocaine self-administration affects pre-existing individual differences in cognit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3f115fbb5e02613e4ec2988185f90af
https://pubmed.ncbi.nlm.nih.gov/21790908

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Akademický článek

Impaired fear extinction as displayed by serotonin transporter knockout rats housed in open cages is disrupted by IVC cage housing.

Autor: Ling Shan, Pieter Schipper, Lourens J P Nonkes, Judith R Homberg

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91472 (2014)

Anxiety disorders are influenced by both environmental and genetic factors. A well-known example for gene x environment interactions in psychiatry is the low activity (s) allelic variant of the serotonin transporter (5-HTT) promoter polymorphism (5-H

Externí odkaz: https://doaj.org/article/a1b66f402d9f483fa2bd8bd087fbae45

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