Dietary nitrate supplementation and cognitive health: the nitric oxide-dependent neurovascular coupling hypothesis.

Autor: Gonçalves JS; Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga 3004-504 Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Health Science Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Marçal AL; Faculty of Pharmacy, University of Coimbra, Health Science Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Marques BS; Faculty of Pharmacy, University of Coimbra, Health Science Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Costa FD; Faculty of Pharmacy, University of Coimbra, Health Science Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Laranjinha J; Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga 3004-504 Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Health Science Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Rocha BS; Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga 3004-504 Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Health Science Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Lourenço CF; Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga 3004-504 Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Health Science Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.

Publikováno v: Biochemical Society transactions [Biochem Soc Trans] 2024 Feb 28; Vol. 52 (1), pp. 279-289.

Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats.

Autor: Gonçalves JS; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal., Seiça RM; Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Laranjinha J; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address: laranjin@ci.uc.pt., Lourenço CF; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address: cflmarques@uc.pt.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2022 Nov 20; Vol. 193 (Pt 2), pp. 669-675. Date of Electronic Publication: 2022 Nov 11.

Microelectrode Sensor for Real-Time Measurements of Nitrite in the Living Brain, in the Presence of Ascorbate.

Autor: Monteiro T; UCIBIO-Applied Molecular Biosciences Unit, REQUIMTE-Rede de Química e Tecnologia, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Monte de Caparica, Portugal., Dias C; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Health Sciences Campus, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Lourenço CF; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Health Sciences Campus, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Ledo A; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Health Sciences Campus, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Barbosa RM; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.; Health Sciences Campus, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Almeida MG; UCIBIO-Applied Molecular Biosciences Unit, REQUIMTE-Rede de Química e Tecnologia, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Monte de Caparica, Portugal.; Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, 2829-511 Monte de Caparica, Portugal.

Publikováno v: Biosensors [Biosensors (Basel)] 2021 Aug 17; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 17.

The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration.

Autor: Ledo A; Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504, Coimbra, Portugal; University of Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal. Electronic address: analedo@ff.uc.pt., Lourenço CF; Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504, Coimbra, Portugal; University of Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal., Cadenas E; Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90089, CA, USA., Barbosa RM; Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504, Coimbra, Portugal; University of Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal., Laranjinha J; Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504, Coimbra, Portugal; University of Coimbra, Faculty of Pharmacy, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2021 Jan; Vol. 162, pp. 500-513. Date of Electronic Publication: 2020 Nov 10.

State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease.

Autor: Rhea, Elizabeth M.^1,2 meredime@uw.edu, Leclerc, Manon^3,4, Yassine, Hussein N.⁵, Capuano, Ana W.⁶, Han Tong⁶, Petyuk, Vladislav A.⁷, Macauley, Shannon L.⁸, Fioramonti, Xavier^9,10, Carmichael, Owen¹¹, Calon, Frederic^3,4,9, Arvanitakis, Zoe⁶

Publikováno v: Aging & Disease. Aug2024, Vol. 15 Issue 4, p1688-1725. 38p.