Biomarkers in Vestibular Schwannoma–Associated Hearing Loss

Autor: Luis Lassaletta, Miryam Calvino, Jose Manuel Morales-Puebla, Pablo Lapunzina, Lourdes Rodriguez-de la Rosa, Isabel Varela-Nieto, Victor Martinez-Glez

Publikováno v: Frontiers in Neurology, Vol 10 (2019)

Vestibular schwannomas (VSs) are benign tumors composed of differentiated neoplastic Schwann cells. They can be classified into two groups: sporadic VS and those associated with neurofibromatosis type 2 (NF2). VSs usually grow slowly, initially causi

Externí odkaz: https://doaj.org/article/105db71cb8ea4a65afc7291a6f77ebdb

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

Autor: Adelaida M. Celaya, Manuel Serrano, Lourdes Rodriguez-de la Rosa, Jose M Bermúdez-Muñoz, Ángela García-Mato, Daniel Muñoz-Espín, Isabel Varela-Nieto

Publikováno v: Antioxidants, Vol 10, Iss 1351, p 1351 (2021)
Antioxidants
Dipòsit Digital de la UB
Universidad de Barcelona
Volume 10
Issue 9
Digital.CSIC. Repositorio Institucional del CSIC
instname

This article belongs to the Special Issue Oxidative Stress and Inflammation in Deafness: Current and Future Therapy.
Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42e9f389875600061827152a41269ef
https://www.repository.cam.ac.uk/handle/1810/330084

Therapeutic efficiency of the APAF‐1 antagonist LPT99 in a rat model of cisplatin‐induced hearing loss

Autor: Adelaida M. Celaya, Isabel Sánchez-Pérez, Julio Contreras, Lourdes Rodriguez-de la Rosa, Silvia Murillo-Cuesta, Jose M Bermúdez-Muñoz, Isabel Varela-Nieto, Blanca Cervantes

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 4, Pp n/a-n/a (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Clinical and Translational Medicine

© 2021 The Authors
Cis-diammine-dichloroplatinum[II] (cisplatin) is a potent and widely used chemotherapeutic agent with significant efficacy against several forms of cancer in adults and children. Unfortunately, cisplatin has multiple adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da89b1fddd3fbbc355e65d3feba94754
https://doaj.org/article/fc9f5b79c9594d15a1502454f34f37e5

IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

Autor: Carlos Romá-Mateo, Adelaida M. Celaya, Lourdes Rodriguez-de la Rosa, Isabel Varela-Nieto, José Manuel Zubeldia, Jose M Bermúdez-Muñoz, Carlos Avendaño, Federico V. Pallardó

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Cells
Cells, Vol 10, Iss 1686, p 1686 (2021)
Volume 10
Issue 7

This article belongs to the Collection Insulin-Like Growth Factors in Development, Cancers and Aging.
Insulin-like growth factor 1 (IGF-1) deficiency is an ultrarare syndromic human sensorineural deafness. Accordingly, IGF-1 is essential for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b61e57b53430a7f1b6700e58433d8aa
http://hdl.handle.net/10261/259393

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

Autor: Adelaida M. Celaya, Isabel Sánchez-Pérez, Isabel Varela-Nieto, Rosario Perona, Lourdes Rodriguez-de la Rosa, Jose M Bermúdez-Muñoz, Silvia Murillo-Cuesta, Laura Pintado-Berninches

Publikováno v: eLife
eLife, Vol 8 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM

Mitogen-activated protein kinases (MAPK) such as p38 and the c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7735ea7a432ee248baaad107938d0e
http://europepmc.org/articles/PMC6464786