Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lourdes Rodríguez‐de la Rosa"'
Autor:
Silvia Murillo-Cuesta, Ester Lara, Jose M. Bermúdez-Muñoz, Elena Torres-Campos, Lourdes Rodríguez-de la Rosa, Pilar López-Larrubia, Signe R. Erickson, Isabel Varela-Nieto
Publikováno v:
Translational Medicine Communications, Vol 8, Iss 1, Pp 1-19 (2023)
Abstract Background The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is critical for maintaining ionic homeostasis and limiting the entry of deleterious agents. BLB integrity is disrupted by bacterial lipopolysacchar
Externí odkaz:
https://doaj.org/article/ab02f00992ea4c529fe44ec4e8fba638
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 233 (2023)
Insulin-like growth factor 1 (IGF-1) is a trophic factor for the nervous system where it exerts pleiotropic effects, including the regulation of metabolic homeostasis. IGF-1 deficiency induces morphological alterations in the cochlea, apoptosis and h
Externí odkaz:
https://doaj.org/article/3fd890ac7f854efb937ef486ce023feb
Autor:
Isabel Varela-Nieto, Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa, María Jesús Oset-Gasque, José Marco-Contelles
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Nitrones are potent antioxidant molecules able to reduce oxidative stress by trapping reactive oxygen and nitrogen species. The antioxidant potential of nitrones has been extensively tested in multiple models of human diseases. Sensorineural hearing
Externí odkaz:
https://doaj.org/article/c4396688f88040e4bf5810aabd9e2200
Autor:
Silvia Murillo‐Cuesta, Adelaida M Celaya, Blanca Cervantes, Jose M Bermúdez‐Muñoz, Lourdes Rodríguez‐de la Rosa, Julio Contreras, Isabel Sánchez‐Pérez, Isabel Varela‐Nieto
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 4, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/fc9f5b79c9594d15a1502454f34f37e5
Autor:
Jose M. Bermúdez-Muñoz, Adelaida M. Celaya, Ángela García-Mato, Daniel Muñoz-Espín, Lourdes Rodríguez-de la Rosa, Manuel Serrano, Isabel Varela-Nieto
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1351 (2021)
Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to sustained SAPK activa
Externí odkaz:
https://doaj.org/article/748624f927dc4e19a79baea627396416
Autor:
Adelaida M. Celaya, Lourdes Rodríguez-de la Rosa, Jose M. Bermúdez-Muñoz, José M. Zubeldia, Carlos Romá-Mateo, Carlos Avendaño, Federico V. Pallardó, Isabel Varela-Nieto
Publikováno v:
Cells, Vol 10, Iss 7, p 1686 (2021)
Insulin-like growth factor 1 (IGF-1) deficiency is an ultrarare syndromic human sensorineural deafness. Accordingly, IGF-1 is essential for the postnatal maturation of the cochlea and the correct wiring of hearing in mice. Less severe decreases in hu
Externí odkaz:
https://doaj.org/article/08b53422302a442ab55b39d6d311fd5a
Autor:
Adelaida M Celaya, Isabel Sánchez-Pérez, Jose M Bermúdez-Muñoz, Lourdes Rodríguez-de la Rosa, Laura Pintado-Berninches, Rosario Perona, Silvia Murillo-Cuesta, Isabel Varela-Nieto
Publikováno v:
eLife, Vol 8 (2019)
Mitogen-activated protein kinases (MAPK) such as p38 and the c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-infl
Externí odkaz:
https://doaj.org/article/e8f5fffe224b4423ad933e7675ed27a8
Autor:
Veronica Fuentes-Santamaría, Juan C. Alvarado, Lourdes Rodríguez-de la Rosa, José M. Juiz, Isabel Varela-Nieto
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Insulin-like growth factor 1 (IGF-1) is a powerful regulator of synaptic activity and a deficit in this protein has a profound impact on neurotransmission, mostly on excitatory synapses in both the developing and mature auditory system. Adult Igf1−
Externí odkaz:
https://doaj.org/article/24ec1e703e4f4053b65eb04ad5c3a3dd
Autor:
Ana I. Arroba, Lourdes Rodríguez-de la Rosa, Silvia Murillo-Cuesta, Laura Vaquero-Villanueva, Juan M. Hurlé, Isabel Varela-Nieto, Ángela M. Valverde
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 9, Pp 965-974 (2016)
Insulin-like growth factor-1 (IGF-1) is a growth factor with differentiating, anti-apoptotic and metabolic functions in the periphery, and anti-inflammatory properties in the nervous system. Mice that have mutations in the Igf1 gene, rendering the ge
Externí odkaz:
https://doaj.org/article/ddc52dfe94754a0480dc11ef47e728a9
Autor:
Lourdes Rodríguez-de la Rosa, Luis Lassaletta, Miryam Calvino, Silvia Murillo-Cuesta, Isabel Varela-Nieto
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Aging is associated with impairment of sensorial functions and with the onset of neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) bioavailability progressively decreases, we see a direct correlation with sens
Externí odkaz:
https://doaj.org/article/4d9009d1454e4f67958290d34a2fbac8