Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lourdes Osuna-Almagro"'
Autor:
Neil P. Dufton, Claire R. Peghaire, Lourdes Osuna-Almagro, Claudio Raimondi, Viktoria Kalna, Abhishek Chauhan, Gwilym Webb, Youwen Yang, Graeme M. Birdsey, Patricia Lalor, Justin C. Mason, David H. Adams, Anna M. Randi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchym
Externí odkaz:
https://doaj.org/article/688d3e51bd6e4384bf9ccbf1181bb7d6
Autor:
Neil P. Dufton, Claire R. Peghaire, Lourdes Osuna-Almagro, Claudio Raimondi, Viktoria Kalna, Abhishek Chauhan, Gwilym Webb, Youwen Yang, Graeme M. Birdsey, Patricia Lalor, Justin C. Mason, David H. Adams, Anna M. Randi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/09a0a6c4e2f844d885132da763c799de
Autor:
Christopher M. Schafer, Silvia Martin-Almedina, Katarzyna Kurylowicz, Neil Dufton, Lourdes Osuna-Almagro, Meng-Ling Wu, Charmain F. Johnson, Aarti V. Shah, Dorian O. Haskard, Andrianna Buxton, Erika Willis, Kate Wheeler, Sean Turner, Magdalena Chlebicz, Rizaldy P. Scott, Susan Kovats, Audrey Cleuren, Graeme M. Birdsey, Anna M. Randi, Courtney T. Griffin
Publikováno v:
bioRxiv
BackgroundDuring infectious diseases, pro-inflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the passage of immune molecules and cells into tissues. However, in the lung the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526ae34af15f04eccb276895f65dccd1
https://doi.org/10.1101/2023.02.08.527788
https://doi.org/10.1101/2023.02.08.527788
Autor:
Patricia F. Lalor, Anna M. Randi, Neil Dufton, Abhishek Chauhan, Gwilym J. Webb, Justin C. Mason, Youwen Yang, Viktoria Kalna, Claire Peghaire, David H. Adams, Claudio Raimondi, Lourdes Osuna-Almagro, Graeme M. Birdsey
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
The role of the endothelium in protecting from chronic liver disease and TGFβ-mediated fibrosis remains unclear. Here we describe how the endothelial transcription factor ETS-related gene (ERG) promotes liver homoeostasis by controlling canonical TG
Autor:
Viktoria, Kalna, Youwen, Yang, Claire R, Peghaire, Karen, Frudd, Rebecca, Hannah, Aarti V, Shah, Lourdes, Osuna Almagro, Joseph J, Boyle, Berthold, Göttgens, Jorge, Ferrer, Anna M, Randi, Graeme M, Birdsey
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: The ETS (E-26 transformation-specific) transcription factor ERG (ETS-related gene) is essential for endothelial homeostasis, driving expression of lineage genes and repressing pro
Rationale: The ETS (E-26 transformation-specific) transcription factor ERG (ETS-related gene) is essential for endothelial homeostasis, driving expression of lineage genes and repressing pro
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation
Autor:
Neil Dufton, Olga Tornavaca, Maria S. Balda, Minghao Chia, Lourdes Osuna Almagro, Daniel E. Conway, Karl Matter, Martin A. Schwartz, Anna M. Randi
Publikováno v:
The Journal of Cell Biology
ZO-1 regulates VE-cadherin–dependent endothelial junctions and actomyosin organization, thereby influencing cell–cell tension, migration, angiogenesis, and barrier formation
Intercellular junctions are crucial for mechanotransduction, but wh
Intercellular junctions are crucial for mechanotransduction, but wh
Autor:
Nicola H. Dryden, Anna M. Randi, Valérie Amsellem, Roberta Martinelli, Justin C. Mason, Felicity N. E. Gavins, Graeme M. Birdsey, Patric Turowski, Dorian O. Haskard, Lourdes Osuna Almagro
Publikováno v:
Cell Communication and Signaling
Cell Communication and Signaling, BioMed Central, 2014, 12 (1), pp.12. ⟨10.1186/1478-811X-12-12⟩
Cell Communication and Signaling : CCS
Cell Communication and Signaling, BioMed Central, 2014, 12 (1), pp.12. ⟨10.1186/1478-811X-12-12⟩
Cell Communication and Signaling : CCS
Background Endothelial junctions control functions such as permeability, angiogenesis and contact inhibition. VE-Cadherin (VECad) is essential for the maintenance of intercellular contacts. In confluent endothelial monolayers, N-Cadherin (NCad) is mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ed9e0744a2d3f641bd2483cd023667
http://bura.brunel.ac.uk/handle/2438/21269
http://bura.brunel.ac.uk/handle/2438/21269
Autor:
Lourdes Osuna Almagro, Ian R. Gould, Neil Dufton, Dorian O. Haskard, Graeme M. Birdsey, Anna M. Randi
Publikováno v:
Heart. 100:A115.2-A116
The ETS transcription factor ERG is constitutively expressed in endothelial cells (EC) and acts as a master-regulator of endothelial function. ERG drives expression of genes which determine endothelial lineage and control homeostasis, such as VE-Cadh
Autor:
Neil Dufton, Kairbaan Hodivala-Dilke, Louise E. Reynolds, Samia Taufiq Khan, Berthold Göttgens, Ralf H. Adams, Anna M. Randi, Aarti V. Shah, Holger Gerhardt, Irene M. Aspalter, Lourdes Osuna Almagro, Graeme M. Birdsey, Elisabetta Dejana, Justin C. Mason, Youwen Yang
Publikováno v:
Developmental Cell
Summary Blood vessel stability is essential for embryonic development; in the adult, many diseases are associated with loss of vascular integrity. The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity. We