GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity

Autor: Sturchler, Emmanuel, Li, Xia, de Lourdes Ladino, Maria, Kaczanowska, Kasia, Cameron, Michael, Griffin, Patrick R, Finn, MG, Markou, Athina, McDonald, Patricia

Publikováno v: Pharmacology research & perspectives, vol 5, iss 2

Positive modulation of the GABAB receptor (GABABR) represents a potentially useful therapeutic approach for the treatment of nicotine addiction. The positive allosteric modulators (PAMs) of GABABR GS39783 and BHF177 enhance GABA-stimulated [35S]GTP �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5a5590af9e1f321d052936abbaab0c7c
https://escholarship.org/uc/item/1cz197m0

GABA B receptor allosteric modulators exhibit pathway-dependent and species-selective activity.

Autor: Sturchler E; Department of Molecular Therapeutics The Scripps Research Institute 130 Scripps way Jupiter Florida 33458., Li X; Department of Psychiatry University of California San Diego 9500 Gilman Drive La Jolla California 92093., de Lourdes Ladino M; Department of Molecular Therapeutics The Scripps Research Institute 130 Scripps way Jupiter Florida 33458; Present address: School of Medicine Vanderbilt University 2215 Garland Ave Nashville Tennessee 37232., Kaczanowska K; Department of Chemistry The Scripps Research Institute 10550 North Torrey Pines Road La Jolla California 92037; Present address: Department of Chemistry University of California San Diego, 9500 Gilman Drive La Jolla California 92093., Cameron M; Department of Molecular Therapeutics The Scripps Research Institute 130 Scripps way Jupiter Florida 33458., Griffin PR; Department of Molecular Therapeutics The Scripps Research Institute 130 Scripps way Jupiter Florida 33458., Finn MG; Department of Chemistry The Scripps Research Institute 10550 North Torrey Pines Road La Jolla California 92037; Present address: Georgia Institute of Technology School of Chemistry and Biochemistry 901 Atlantic Drive Atlanta Georgia 30332., Markou A; Department of Psychiatry University of California San Diego 9500 Gilman Drive La Jolla California 92093., McDonald P; Department of Molecular Therapeutics The Scripps Research Institute 130 Scripps way Jupiter Florida 33458.

Publikováno v: Pharmacology research & perspectives [Pharmacol Res Perspect] 2017 Mar 24; Vol. 5 (2), pp. e00288. Date of Electronic Publication: 2017 Mar 24 (Print Publication: 2017).