Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lourdes Garcia‐Quintanilla"'
Autor:
Phillip L.R. Nicolson, Sophie H. Nock, Joshua Hinds, Lourdes Garcia-Quintanilla, Christopher W. Smith, Joana Campos, Alexander Brill, Jeremy A. Pike, Abdullah O. Khan, Natalie S. Poulter, Diedre M. Kavanagh, Stephanie Watson, Callum N. Watson, Hayley Clifford, Aarnoud P. Huissoon, Alice Y. Pollitt, Johannes A. Eble, Guy Pratt, Steve P. Watson, Craig E. Hughes
Publikováno v:
Haematologica, Vol 106, Iss 1 (2020)
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2
Externí odkaz:
https://doaj.org/article/488fe4d4fc05448a940504d50e98e98e
Autor:
Christopher W. Smith, Maan H. Harbi, Lourdes Garcia‐Quintanilla, Kieran Rookes, Helena Brown, Natalie S. Poulter, Steve P. Watson, Phillip L.R. Nicolson, Mark R. Thomas
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2939-2952
New antithrombotic therapies with less effect on bleeding are needed for coronary artery disease. The Btk inhibitor ibrutinib blocks atherosclerotic plaque-mediated thrombus formation. However, it is associated with increased bleeding, possibly due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c27851d0231ac62d8412e29ceb9543
https://doi.org/10.1111/jth.15899
https://doi.org/10.1111/jth.15899
Autor:
Paula M. Mendes, Pushpa Patel, Magdolna Nagy, Samantha J. Montague, Eleyna M. Martin, Lourdes Garcia Quintanilla, Alexandre Slater, Caroline Kardeby, Steve P. Watson, Gina Perrella, Diego Mezzano
Publikováno v:
Platelets, 32(8), 1018-1030. Routledge/Taylor & Francis Group
Charge interactions play a critical role in the activation of the innate immune system by damage- and pathogen-associated molecular pattern receptors. The ability of these receptors to recognize a wide spectrum of ligands through a common mechanism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dfdd348fd90bb08cd2473bbf672257
https://doi.org/10.1080/09537104.2021.1945571
https://doi.org/10.1080/09537104.2021.1945571
Autor:
Neil V. Morgan, Lorena Azocar, Gina Perrella, Jeremy A. Pike, Magdolna Nagy, Elizabeth E. Gardiner, Amanda Dalby, Johan W. M. Heemskerk, Steve P. Watson, Juan Francisco Miquel, Lourdes Garcia Quintanilla, Diego Mezzano, M. Francisca Becerra
Publikováno v:
Blood Adv
Blood advances, 4(13), 2953-2961. The American Society of Hematology
Blood advances, 4(13), 2953-2961. The American Society of Hematology
The role of glycoprotein VI (GPVI) in platelets was investigated in 3 families bearing an insertion within the GP6 gene that introduces a premature stop codon prior to the transmembrane domain, leading to expression of a truncated protein in the cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31e31e5a7031fa939f454d88c3db430
https://doi.org/10.1182/bloodadvances.2020001761
https://doi.org/10.1182/bloodadvances.2020001761
Autor:
Natalie S. Poulter, Joshua Hinds, Alexander Brill, Abdullah O. Khan, Sophie H. Nock, Phillip L R Nicolson, Craig E. Hughes, Joana Campos, Alice Y. Pollitt, Johannes A. Eble, Diedre M Kavanagh, Steve P. Watson, Callum N. Watson, Aarnoud Huissoon, Guy Pratt, Lourdes Garcia-Quintanilla, Christopher W Smith, Hayley Clifford, Stephanie Watson, Jeremy A. Pike
Publikováno v:
Haematologica. 106:208-219
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf28059a9af3a75cc3028f371937372c
https://doi.org/10.3324/haematol.2019.218545
https://doi.org/10.3324/haematol.2019.218545
Autor:
Gina Perrella, Samantha J. Montague, Helena C. Brown, Lourdes Garcia Quintanilla, Alexandre Slater, David Stegner, Mark Thomas, Johan W. M. Heemskerk, Steve P. Watson
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 493
International Journal of Molecular Sciences, 23(1):493. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 493, p 493 (2022)
International Journal of Molecular Sciences, 23(1):493. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 493, p 493 (2022)
Understanding the pathways involved in the formation and stability of the core and shell regions of a platelet-rich arterial thrombus may result in new ways to treat arterial thrombosis. The distinguishing feature between these two regions is the abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f938d0bbad73b8c836f8f6069bf1475
Autor:
Lourdes Garcia-Quintanilla, Phillip L R Nicolson, Katrien Devreese, Caroline Kardeby, Stephen P. Watson, Walid Chayoua, Joost C. M. Meijers, Philip G. de Groot, Bas de Laat
Publikováno v:
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Journal of Thrombosis and Haemostasis
Journal of thrombosis and haemostasis, 19(7), 1776-1782. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 19(7), 1776-1782. Wiley
Journal of Thrombosis and Haemostasis
Journal of thrombosis and haemostasis, 19(7), 1776-1782. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 19(7), 1776-1782. Wiley
Background Arterial and venous thrombosis are both common in antiphospholipid syndrome (APS). Recent studies have shown that anti-factor Xa (FXa) therapy in APS patients leads to a greater number of patients with arterial thrombosis than with warfari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a9ffd6caa5d2d633ee8d1167a36759
https://hdl.handle.net/1854/LU-8703948
https://hdl.handle.net/1854/LU-8703948
Autor:
Marie-Blanche, Onselaer, Magdolna, Nagy, Chiara, Pallini, Jeremy A, Pike, Gina, Perrella, Lourdes Garcia, Quintanilla, Johannes A, Eble, Natalie S, Poulter, Johan W M, Heemskerk, Steve P, Watson
Publikováno v:
Platelets
Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c42ef152ce8795f182a0ac225730909
https://pubmed.ncbi.nlm.nih.gov/30849265
https://pubmed.ncbi.nlm.nih.gov/30849265
Autor:
Alejandro Álvarez-Quilón, José Terrón-Bautista, Irene Delgado-Sainz, Almudena Serrano-Benítez, Rocío Romero-Granados, Pedro Manuel Martínez-García, Silvia Jimeno-González, Cristina Bernal-Lozano, Cristina Quintero, Lourdes García-Quintanilla, Felipe Cortés-Ledesma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2 −/− Atm −/− double-deficient mouse model to
Externí odkaz:
https://doaj.org/article/9f1676662817487ea864a82ec0a5a86d
Autor:
Samantha J. Montague, Pushpa Patel, Eleyna M. Martin, Alexandre Slater, Lourdes Garcia Quintanilla, Gina Perrella, Caroline Kardeby, Magdolna Nagy, Diego Mezzano, Paula M. Mendes, Steve P. Watson
Publikováno v:
Platelets, Vol 32, Iss 8, Pp 1018-1030 (2021)
Charge interactions play a critical role in the activation of the innate immune system by damage- and pathogen-associated molecular pattern receptors. The ability of these receptors to recognize a wide spectrum of ligands through a common mechanism i
Externí odkaz:
https://doaj.org/article/d68fe07341ea448db1db66c9eedf4d5e