Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Lourdes Cruz-Garcia"'
Autor:
Natalie Brown, Rosemary Finnon, Paul Finnon, Roisin McCarron, Lourdes Cruz-Garcia, Grainne O’Brien, Eleanor Herbert, Cheryl L. Scudamore, Edouard Morel, Christophe Badie
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107530- (2023)
Summary: Ionizing radiation (IR) is a risk factor for acute myeloid leukemia (rAML). Murine rAMLs feature both hemizygous chromosome 2 deletions (Del2) and point mutations (R235) within the hematopoietic regulatory gene Spi1. We generated a heterozyg
Externí odkaz:
https://doaj.org/article/3a11095d3f2342bdb9b60e049777d4d7
Autor:
Gráinne O’Brien, Malgorzata Kamuda, Lourdes Cruz-Garcia, Mariia Polozova, Ales Tichy, Marketa Markova, Igor Sirak, Oldrich Zahradnicek, Piotr Widłak, Lucyna Ponge, Joanna Polanska, Christophe Badie
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1080 (2024)
Cancer and ionizing radiation exposure are associated with inflammation. To identify a set of radiation-specific signatures of inflammation-associated genes in the blood of partially exposed radiotherapy patients, differential expression of 249 infla
Externí odkaz:
https://doaj.org/article/bde703d48dc748f4a24257a3fc261678
Autor:
Lourdes Cruz-Garcia, Christophe Badie, Selvakumar Anbalagan, Jayne Moquet, Lone Gothard, Grainne O’Brien, Navita Somaiah, Elizabeth A. Ainsbury
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-10 (2021)
Abstract Background This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients. Methods Peripheral blood sample
Externí odkaz:
https://doaj.org/article/5af9b4ff73ea42428c4ef5e6d80dc60e
Autor:
Ilona Barbara Csordás, Eric Andreas Rutten, Tünde Szatmári, Prabal Subedi, Lourdes Cruz-Garcia, Dávid Kis, Bálint Jezsó, Christine von Toerne, Martina Forgács, Géza Sáfrány, Soile Tapio, Christophe Badie, Katalin Lumniczky
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8607 (2023)
Extracellular vesicles (EVs), through their cargo, are important mediators of bystander responses in the irradiated bone marrow (BM). MiRNAs carried by EVs can potentially alter cellular pathways in EV-recipient cells by regulating their protein cont
Externí odkaz:
https://doaj.org/article/da32caad9291454fa78534468cedd68c
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 11 (2021)
Haematopoietic bone marrow cells are amongst the most sensitive to ionizing radiation (IR), initially resulting in cell death or genotoxicity that may later lead to leukaemia development, most frequently Acute Myeloid Leukaemia (AML). The target cell
Externí odkaz:
https://doaj.org/article/abf58c8ed23b4885a46df3ed6bbc927c
Autor:
Lourdes Cruz-Garcia, Grainne O’Brien, Botond Sipos, Simon Mayes, Aleš Tichý, Igor Sirák, Marie Davídková, Markéta Marková, Daniel J. Turner, Christophe Badie
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7851 (2020)
Following cell stress such as ionising radiation (IR) exposure, multiple cellular pathways are activated. We recently demonstrated that ferredoxin reductase (FDXR) has a remarkable IR-induced transcriptional responsiveness in blood. Here, we provided
Externí odkaz:
https://doaj.org/article/a2c7ba0be4ca4cebb13e7cd78bba75f7
Autor:
Lourdes Cruz-Garcia, Amnon Schlegel
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1944-1958 (2014)
Liver X receptors (Lxrs) are master regulators of cholesterol catabolism, driving the elimination of cholesterol from the periphery to the lumen of the intestine. Development of pharmacological agents to activate Lxrs has been hindered by synthetic L
Externí odkaz:
https://doaj.org/article/62c5b038f67c49a4952d99d819096191
Autor:
Stanislav Polozov, Lourdes Cruz-Garcia, Grainne O'Brien, Veronika Goriacha, Farah Nasser, Penelope Jeggo, Serge Candéias, Christophe Badie
Publikováno v:
Advances in Radiation Oncology. 8:101215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc0af8cf52fef1857e2508b79dcc1f4
https://doi.org/10.1016/j.adro.2023.101215
https://doi.org/10.1016/j.adro.2023.101215
Autor:
Rosemary Finnon, Christophe Badie, Grainne O’Brien, Natalie Brown, Joanna Polanska, Joanna Zyla, Lourdes Cruz-Garcia
Publikováno v:
Carcinogenesis
Therapy-related and more specifically radiotherapy-associated acute myeloid leukaemia (AML) is a well-recognized potential complication of cytotoxic therapy for the treatment of a primary cancer. The CBA mouse model is used to study radiation leukaem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23d0ea0c181be420e1f2c92f26f36a0
https://doi.org/10.1093/carcin/bgz175
https://doi.org/10.1093/carcin/bgz175
Autor:
Lone Gothard, Selvakumar Anbalagan, Jayne Moquet, Grainne O’Brien, Navita Somaiah, Christophe Badie, Elizabeth A. Ainsbury, Lourdes Cruz-Garcia
Publikováno v:
Radiation Oncology (London, England)
Radiation Oncology, Vol 16, Iss 1, Pp 1-10 (2021)
Radiation Oncology, Vol 16, Iss 1, Pp 1-10 (2021)
Background This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients. Methods Peripheral blood samples were ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27d110663a18c95205fd1b2eef07452
https://doi.org/10.1186/s13014-021-01807-4
https://doi.org/10.1186/s13014-021-01807-4