Zobrazeno 1 - 10 of 864 pro vyhledávání: '"Loupakis Fotios"'
1
Akademický článek
Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer
Autor: Manzoni Mariangela, Ricci Vincenzo, Bencardino Katia, Santini Daniele, Vincenzi Bruno, Canestrari Emanuele, Galluccio Nadia, Catalano Vincenzo, Frumento Paolo, Schirripa Marta, Masi Gianluca, Cremolini Chiara, Ruzzo Annamaria, Salvatore Lisa, Loupakis Fotios, Danova Marco, Tonini Giuseppe, Magnani Mauro, Falcone Alfredo, Graziano Francesco
Publikováno v: BMC Cancer, Vol 11, Iss 1, p 247 (2011)
Abstract Background Molecular predictors of bevacizumab efficacy in colorectal cancer have not been identified yet. Specific VEGF polymorphisms may affect gene transcription and therefore indirectly influence the efficacy of bevacizumab. Methods Geno
Externí odkaz: https://doaj.org/article/d0d3ccc86ec147918e417ad73faa21aa
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2
Akademický článek
Magnitude of benefit of the addition of bevacizumab to first-line chemotherapy for metastatic colorectal cancer: meta-analysis of randomized clinical trials
Autor: Falcone Alfredo, Salvatore Lisa, Cremolini Chiara, Carlini Paolo, Milella Michele, Cuppone Federica, Vaccaro Vanja, Bria Emilio, Loupakis Fotios, Muti Paola, Sperduti Isabella, Giannarelli Diana, Cognetti Francesco
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 29, Iss 1, p 58 (2010)
Abstract Background Although the addition of bevacizumab to 1st line chemotherapy provides a significant survival benefit for advanced colorectal cancer, the magnitudes of both advantages and toxicities have not been extensively investigated. Methods
Externí odkaz: https://doaj.org/article/395db3ad83e44a368f1af0c801c0f644
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3
Akademický článek
Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis
Autor: Scartozzi Mario, Bearzi Italo, Mandolesi Alessandra, Pierantoni Chiara, Loupakis Fotios, Zaniboni Alberto, Negri Francesca, Quadri Antonello, Zorzi Fausto, Galizia Eva, Berardi Rossana, Biscotti Tommasina, Labianca Roberto, Masi Gianluca, Falcone Alfredo, Cascinu Stefano
Publikováno v: BMC Cancer, Vol 9, Iss 1, p 303 (2009)
Abstract Background K-RAS wild type colorectal tumors show an improved response rate to anti-EGFR monoclonal antibodies. Nevertheless 70% to 40% of these patients still does not seem to benefit from this therapeutic approach. FISH EGFR GCN has been p
Externí odkaz: https://doaj.org/article/09b4f251f761445e89832cd8dcfa91fe
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