A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.

Autor: Ackloo S; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Li F; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Szewczyk M; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Seitova A; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Loppnau P; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Zeng H; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Xu J; Google, 1600 Amphitheatre Parkway, Mountain View, California 94043, United States., Ahmad S; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Arnautova YA; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Baghaie AJ; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Beldar S; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Bolotokova A; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Centrella PA; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Chau I; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Clark MA; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Cuozzo JW; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Dehghani-Tafti S; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Disch JS; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Dong A; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Dumas A; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Feng JA; Google, 1600 Amphitheatre Parkway, Mountain View, California 94043, United States., Ghiabi P; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Gibson E; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Gilmer J; Google, 1600 Amphitheatre Parkway, Mountain View, California 94043, United States., Goldman B; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Green SR; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Guié MA; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Guilinger JP; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Harms N; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Herasymenko O; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Houliston S; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2M9, Canada., Hutchinson A; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Kearnes S; Google, 1600 Amphitheatre Parkway, Mountain View, California 94043, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Keefe AD; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Kimani SW; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Kramer T; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Kutera M; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Kwak HA; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Lento C; Department of Chemistry, York University, Toronto, ON M3J 1P3, Canada., Li Y; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Liu J; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Loup J; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Machado RAC; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Mulhern CJ; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Perveen S; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Righetto GL; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Riley P; Google, 1600 Amphitheatre Parkway, Mountain View, California 94043, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Shrestha S; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Sigel EA; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Silva M; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Sintchak MD; Civetta Therapeutics, 10 Wilson Rd., Cambridge, Massachusetts 02138, United States., Slakman BL; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Taylor RD; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Thompson J; Google, 1600 Amphitheatre Parkway, Mountain View, California 94043, United States., Torng W; Google, 1600 Amphitheatre Parkway, Mountain View, California 94043, United States., Underkoffler C; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., von Rechenberg M; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Walsh RT; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Watson I; Google, 1600 Amphitheatre Parkway, Mountain View, California 94043, United States., Wilson DJ; Department of Chemistry, York University, Toronto, ON M3J 1P3, Canada., Wolf E; Department of Chemistry, York University, Toronto, ON M3J 1P3, Canada., Yadav M; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Yazdi AK; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Zhang J; ZebiAI Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States.; Relay Therapeutics, 399 Binney St., Cambridge, Massachusetts 02139, United States., Zhang Y; X-Chem Inc., 100 Beaver St., Waltham, Massachusetts 02435, United States., Santhakumar V; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Edwards AM; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada., Schapira M; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada., Brown PJ; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada., Halabelian L; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON M5G 1L7, Canada.; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2M9, Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 04. Date of Electronic Publication: 2024 Nov 04.

Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer

Autor: Bantzi, M. Augsburger, F. Loup, J. Berset, Y. Vasilakaki, S. Myrianthopoulos, V. Mikros, E. Szabo, C. Bochet, C.G.

The enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is one of the more recently identified mammalian sources of H2S. A recent study identified several novel 3-MST inhibitors with micromolar potency. Among those, (2-[(4-hydroxy-6-methylpyrimidin-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::88073daaede3214def4096bf6b6b6194
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020321

Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer.

Autor: Bantzi M; Department of Chemistry, University of Fribourg, 1700 Fribourg, Switzerland.; Chair of Pharmacology, Faculty of Science and Medicine University of Fribourg, 1700 Fribourg, Switzerland., Augsburger F; Chair of Pharmacology, Faculty of Science and Medicine University of Fribourg, 1700 Fribourg, Switzerland., Loup J; Department of Chemistry, University of Fribourg, 1700 Fribourg, Switzerland., Berset Y; Department of Chemistry, University of Fribourg, 1700 Fribourg, Switzerland., Vasilakaki S; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, 15772 Athens, Greece., Myrianthopoulos V; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, 15772 Athens, Greece., Mikros E; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, 15772 Athens, Greece., Szabo C; Chair of Pharmacology, Faculty of Science and Medicine University of Fribourg, 1700 Fribourg, Switzerland., Bochet CG; Department of Chemistry, University of Fribourg, 1700 Fribourg, Switzerland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6221-6240. Date of Electronic Publication: 2021 Apr 15.

Enhancing sleep quality for nursing home residents with dementia: a pragmatic randomized controlled trial of an evidence-based frontline huddling program.

Autor: Snow AL; Alabama Research Institute on Aging and the Department of Psychology, The University of Alabama, Gordon Palmer Hall, Tuscaloosa, AL, 35487, USA. Lsnow@UA.edu.; Tuscaloosa Veterans Affairs Medical Center, Tuscaloosa, AL, 35404, USA. Lsnow@UA.edu., Loup J; Alabama Research Institute on Aging and the Department of Psychology, The University of Alabama, Gordon Palmer Hall, Tuscaloosa, AL, 35487, USA.; Tuscaloosa Veterans Affairs Medical Center, Tuscaloosa, AL, 35404, USA., Morgan RO; Department of Management, Policy and Community Health, School of Public Health, The University of Texas Health Science Center at Houston, Houston, USA., Richards K; School of Nursing, The University of Texas at Austin, Austin, TX, 78701-1412, USA., Parmelee PA; Alabama Research Institute on Aging and the Department of Psychology, The University of Alabama, Gordon Palmer Hall, Tuscaloosa, AL, 35487, USA., Baier RR; Brown University School of Public Health, Providence, RI, 02912, USA., McCreedy E; Brown University School of Public Health, Providence, RI, 02912, USA., Frank B; B&F Consulting, Warren, RI, 02885, USA., Brady C; B&F Consulting, Warren, RI, 02885, USA., Fry L; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, 78712, USA., McCullough M; Department of Public Health, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA, 01854, USA.; Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, Bedford, MA, 01730, USA., Hartmann CW; Department of Public Health, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA, 01854, USA.; Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, Bedford, MA, 01730, USA.

Publikováno v: BMC geriatrics [BMC Geriatr] 2021 Apr 27; Vol. 21 (1), pp. 281. Date of Electronic Publication: 2021 Apr 27.

Development and Refinement of Educational Materials to Help Older Veterans Use VA Mental Health Mobile Apps.

Autor: Gould CE; Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA., Loup J; Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, CA, USA., Scales AN; Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, CA, USA., Juang C; Psychology Service, VA Palo Alto Health Care System., Carlson C; Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, CA, USA., Ma F; Psychology Service, VA Palo Alto Health Care System.; Pacific Graduate School of Psychology, Palo Alto University., Sakai EY; Psychology Service, VA Palo Alto Health Care System.

Publikováno v: Professional psychology, research and practice [Prof Psychol Res Pr] 2020 Aug; Vol. 51 (4), pp. 414-423. Date of Electronic Publication: 2020 Jul 16.