An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets

Autor: Papageorgiou, L. Loukatou, S. Sofia, K. Maroulis, D. Vlachakis, D.

The rate of Flaviviridae family virus infections worldwide has increased dramatically in the last few years. In addition, infections caused by arthropod vector viruses including Hepatitis C, West Nile, Dengue fever, Yellow fever and Japanese encephal

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https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3086102

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Molecular dynamics simulations through GPU video games technologies.

Autor: Loukatou S; Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece., Papageorgiou L; Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece; Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, University Campus, Athens 15784, Greece., Fakourelis P; Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece; Department of Computer Engineering and Informatics Faculty, University of Patras, Patras 26500, Greece., Filntisi A; Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece; School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece., Polychronidou E; Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece; Department of Informatics, Ionian University, Tsirigoti Square 7, Corfu 49100, Greece., Bassis I; Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece., Megalooikonomou V; Department of Computer Engineering and Informatics Faculty, University of Patras, Patras 26500, Greece., Makałowski W; Institute of Bioinformatics, University of Münster, Niels-Stensen-Straße 14, Münster 48149, Germany., Vlachakis D; Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece; Department of Computer Engineering and Informatics Faculty, University of Patras, Patras 26500, Greece; Bionetwork ltd. 15234, Chalandri, Athens, Greece., Kossida S; Computational Biology & Medicine Group, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens 11527, Greece.

Publikováno v: Journal of molecular biochemistry [J Mol Biochem] 2014; Vol. 3 (2), pp. 64-71. Date of Electronic Publication: 2014 Jun 30.