Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

Autor: Bas Molenaar, Louk T. Timmer, Marjolein Droog, Ilaria Perini, Danielle Versteeg, Lieneke Kooijman, Jantine Monshouwer-Kloots, Hesther de Ruiter, Monika M. Gladka, Eva van Rooij

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)

Molenaar et al. use scRNA-seq to profile cardiac cell gene expression changes at three time points following ischemic injury. They observe that B2M is secreted by cardiomyocytes following injury, promoting scar formation. This data may be useful in f

Externí odkaz: https://doaj.org/article/4ad3dd3f14f6498bac1a498a6c119c9c

The role of IGF-1 signaling in skeletal muscle atrophy

Autor: Richard T. Jaspers, Louk T. Timmer, Willem M.H. Hoogaars

Publikováno v: Muscle atrophy, 1088, 109-137
Advances in Experimental Medicine and Biology ISBN: 9789811314346
Timmer, L T, Hoogaars, W M H & Jaspers, R T 2018, The role of IGF-1 signaling in skeletal muscle atrophy . in Muscle atrophy . vol. 1088, Advances in Experimental Medicine and Biology, vol. 1088, Springer New York LLC, pp. 109-137 . https://doi.org/10.1007/978-981-13-1435-3_6

Insulin-like growth factor 1 (IGF-1) is a key anabolic growth factor stimulating phosphatidylinositol 3-kinase (PI3K)/Akt signaling which is well known for regulating muscle hypertrophy. However, the role of IGF-1 in muscle atrophy is less clear. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f96d13f5ec3781c1bcc5ca7cff76ffd
https://hdl.handle.net/1871.1/b1a62cfe-0264-4887-91b0-9411e256ac48