C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors in vitro

Autor: A. Robin Temming, Matthias Tammes Buirs, Arthur E. H. Bentlage, Louise W. Treffers, Hannah Feringa, Steven W. de Taeye, Taco W. Kuijpers, Sietse Q. Nagelkerke, Giso Brasser, Juk Yee Mok, Wim J. E. van Esch, Timo K. van den Berg, Theo Rispens, C. Ellen van der Schoot, Gestur Vidarsson

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells, many factors are still

Externí odkaz: https://doaj.org/article/a051437a3dee48c7afce6b02bcb366cb

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

Autor: Hanke L. Matlung, Liane Babes, Xi Wen Zhao, Michel van Houdt, Louise W. Treffers, Dieke J. van Rees, Katka Franke, Karin Schornagel, Paul Verkuijlen, Hans Janssen, Pasi Halonen, Cor Lieftink, Roderick L. Beijersbergen, Jeanette H.W. Leusen, Jaap J. Boelens, Ingrid Kuhnle, Jutte van der Werff Ten Bosch, Karl Seeger, Sergio Rutella, Daria Pagliara, Takashi Matozaki, Eiji Suzuki, Catharina Willemien Menke-van der Houven van Oordt, Robin van Bruggen, Dirk Roos, Rene A.W. van Lier, Taco W. Kuijpers, Paul Kubes, Timo K. van den Berg

Publikováno v: Cell Reports, Vol 23, Iss 13, Pp 3946-3959.e6 (2018)

Summary: Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc-receptor-expressing immune cells, including neutrophils. However,

Externí odkaz: https://doaj.org/article/949872a446914ec6b8703403d441a789

Data from IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47–SIRPα Checkpoint Inhibition

Autor: Hanke L. Matlung, Jeanette H.W. Leusen, Thomas Valerius, Timo K. van den Berg, Taco W. Kuijpers, Katka Franke, Jan M. Prins, Paul J.J.H. Verkuijlen, Karin Schornagel, Steffen Kahle, Michel van Houdt, J.H. Marco Jansen, Thies Rösner, Toine ten Broeke, Louise W. Treffers

Therapeutic monoclonal antibodies (mAb), directed toward either tumor antigens or inhibitory checkpoints on immune cells, are effective in cancer therapy. Increasing evidence suggests that the therapeutic efficacy of these tumor antigen–targeting m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed4d0b16a582b60db76330392fc3c53
https://doi.org/10.1158/2326-6066.c.6550411.v1

Supplementary Figures from IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47–SIRPα Checkpoint Inhibition

Autor: Hanke L. Matlung, Jeanette H.W. Leusen, Thomas Valerius, Timo K. van den Berg, Taco W. Kuijpers, Katka Franke, Jan M. Prins, Paul J.J.H. Verkuijlen, Karin Schornagel, Steffen Kahle, Michel van Houdt, J.H. Marco Jansen, Thies Rösner, Toine ten Broeke, Louise W. Treffers

Supplementary Figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9b8f6a57e4ee63d57d35612a94a925
https://doi.org/10.1158/2326-6066.22543804.v1

Genetic variation of human neutrophil Fcγ receptors and SIRPα in antibody-dependent cellular cytotoxicity towards cancer cells

Autor: Timo K. van den Berg, Judy Geissler, Taco W. Kuijpers, Patricia Gonzalez, Xi Wen Zhao, Sietse Q. Nagelkerke, Joris van der Heijden, Michel van Houdt, Hanke L. Matlung, Martin de Boer, Paul Verkuijlen, Dieke J van Rees, Louise W. Treffers

Publikováno v: Treffers, L W, Zhao, X W, van der Heijden, J, Nagelkerke, S Q, van Rees, D J, Gonzalez, P, Geissler, J, Verkuijlen, P, van Houdt, M, de Boer, M, Kuijpers, T W, van den Berg, T K & Matlung, H L 2018, ' Genetic variation of human neutrophil Fcγ receptors and SIRPα in antibody-dependent cellular cytotoxicity towards cancer cells ', European Journal of Immunology, vol. 48, no. 2, pp. 344-354 . https://doi.org/10.1002/eji.201747215
European Journal of Immunology, 48(2), 344-354. Wiley-VCH Verlag
European journal of immunology, 48(2), 344-354. Wiley-VCH Verlag

The efficacy of cancer therapeutic antibodies varies considerably among patients. Anticancer antibodies act through different mechanisms, including antibody-dependent cellular cytotoxicity (ADCC) triggered via Fc gamma receptors (Fc gamma R). This ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4d039b7716657adbd8fbbe407227bf
https://research.vumc.nl/en/publications/907cf272-4dd8-4fd6-9f8b-d657babe3e0d