Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Louise V. Smith"'
Publikováno v:
Biophysical Chemistry. 126:117-123
Isothermal titration (ITC) and differential scanning calorimetry (DSC) have been used to screen the binding thermodynamics of a family of DNA intercalators based on the dihydro-imidazo-phenanthridinium (DIP) framework. All members of this DIP-based l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d62fa0502805ec92e54f5e072d74a8
https://doi.org/10.1016/j.bpc.2006.05.006
https://doi.org/10.1016/j.bpc.2006.05.006
Publikováno v:
Tetrahedron. 61:8410-8418
Secondary amines and thiols undertake a substitution reaction on the side chain of 2-bromoethyl-pyridinium derivatives ‘directed’ by an intramolecular re-arrangement. Experimental investigations strongly indicate that the reaction is initiated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c462f3acd43c036b30b2ec6886925dee
https://doi.org/10.1016/j.tet.2005.06.074
https://doi.org/10.1016/j.tet.2005.06.074
Autor:
Robert S. Brown, Jane A. Plumb, Louise V. Smith, Leroy Cronin, Alexis D. C. Parenty, Kevin M. Guthrie
Publikováno v:
Chembiochem : a European journal of chemical biology. 7(11)
We have synthesised a library of dihydroimidazophenanthridinium cations (DIPs) with large structural diversity (1–29) using a “one-pot” approach. The DNA binding constants of DIPs range from 2 ' 10 4 to 1.3 ' 10 5 m � 1 , and the free energie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e858bf0d6261281f5ad21d2e804fd37a
https://pubmed.ncbi.nlm.nih.gov/17031882
https://pubmed.ncbi.nlm.nih.gov/17031882
Autor:
Leroy Cronin, Louise V. Smith, Alexis D. C. Parenty, Kevin M. Guthrie, Eric Burkholder, Yu-Fei Song
Publikováno v:
ChemInform. 37
A new class of heterocyclic aromatic cation with novel physical properties has been constructed by an unprecedented reaction pathway that proceeds via five spontaneous steps to yield a ‘synthon’ that can be further derivatised by a final nucleoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18611009c017a6b956a149585287a1fc
https://doi.org/10.1002/chin.200632177
https://doi.org/10.1002/chin.200632177
Autor:
De-Liang Long, Kevin M. Guthrie, Jane A. Plumb, Robert S. Brown, Louise V. Smith, Leroy Cronin, Alexis D. C. Parenty
Publikováno v:
Journal of medicinal chemistry. 48(14)
A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7986719c5e47f43b70bf02e88092d33f
https://pubmed.ncbi.nlm.nih.gov/15999988
https://pubmed.ncbi.nlm.nih.gov/15999988
Publikováno v:
The Journal of organic chemistry. 69(18)
A new class of phenanthridinium derivative has been isolated from the reaction of 2-bromoethyl-phenanthridinium bromide with a range of primary amines in excellent yields. The reaction pathway is unprecedented and proceeds via three cascade steps: nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac88af59202649296d8939c05304205
https://pubmed.ncbi.nlm.nih.gov/15373478
https://pubmed.ncbi.nlm.nih.gov/15373478
Autor:
Andrew R. Pitt, Alexis D. C. Parenty, Nicola McMillan, Sharon M. Kelly, Katrina Thomson, Jesús M. de la Fuente, Nikolaj Gadegaard, Leroy Cronin, Louise V. Smith, Cameron D. Mackenzie
Publikováno v:
Chemical Communications. :2581
N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d86ee791c2935acacc8b1bd644d0ca
https://doi.org/10.1039/b702575k
https://doi.org/10.1039/b702575k
Autor:
Alexis D. C. Parenty, Kevin M. Guthrie, Eric Burkholder, Louise V. Smith, Y.-F. Song, Leroy Cronin
Publikováno v:
Synfacts. 2006:0554-0554
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ad1dc98a2d7950ff53b7678c7a4b8d
https://doi.org/10.1055/s-2006-934467
https://doi.org/10.1055/s-2006-934467
Publikováno v:
New Journal of Chemistry. 29:1118
Ultrafiltration analysis has been used to screen DNA oligonucleotide interactive small molecules for the first time, providing an almost instantaneous indication of the binding affinity, and was used to identify a new class of DNA interactive molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::452729939813e67efeb4f53136cea0fd
https://doi.org/10.1039/b507037f
https://doi.org/10.1039/b507037f
Autor:
Louise V. Smith, Alexis D. C. Parenty, Kevin M. Guthrie, Jane Plumb, Robert Brown, Leroy Cronin
Publikováno v:
ChemBioChem; Nov2006, Vol. 7 Issue 11, p1757-1763, 7p