Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies

Autor: Fiona Broughton Pipkin, Amy Simpson, Louise V. Briggs, Carolyn J.P. Jones, David S. Gardner, Lesia O. Kurlak, Paula J. Scaife, Hiten D. Mistry

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7295, p 7295 (2021)
Volume 22
Issue 14
Scaife, P J, Simpson, A, Kurlak, L O, Briggs, L V, Gardner, D S, Pipkin, F B, Jones, C J P & Mistry, H D 2021, ' Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies ', International Journal of Molecular Sciences, vol. 22, no. 14, 7295 . https://doi.org/10.3390/ijms22147295

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c9473ee6405a3243e91a8da6648825
http://europepmc.org/articles/PMC8303298

Comparison of in vitro pre-eclampsia (PE) cell models with PE placental tissue

Autor: Louise V. Briggs, Henning Schneider, Sampada Kallol, Hiten D. Mistry, Christiane Albrecht, Ruedi Moser

Publikováno v: Placenta. 83:e104

Objectives: We induced hypoxia and oxidative stress (OS) in cytotrophoblasts (CTB) from control placentae to mimic the characteristics of preeclampsia (PE). For validation we compared the gene and protein expression of established PE biomarkers betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f73208cc7c21a7aa198202ac788728c
https://doi.org/10.1016/j.placenta.2019.06.329