Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Louise Stjernborg"'
Autor:
Susan Monkley, Jayendra Kumar Krishnaswamy, Melker Göransson, Maryam Clausen, Johan Meuller, Kristofer Thörn, Ryan Hicks, Stephen Delaney, Louise Stjernborg
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243807 (2020)
Induced pluripotent stem cells (iPSC) offer the possibility to generate diverse disease-relevant cell types, from any genetic background with the use of cellular reprogramming and directed differentiation. This provides a powerful platform for diseas
Externí odkaz:
https://doaj.org/article/8866dc9e7d7c4d558c5325042769e7f8
Autor:
Louise Stjernborg, Johan Meuller, Jayendra Kumar Krishnaswamy, Melker Göransson, Maryam Clausen, Ryan Hicks, Kristofer Thörn, Stephen Delaney, Susan J. Monkley
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0243807 (2020)
PLoS ONE, Vol 15, Iss 12, p e0243807 (2020)
Induced pluripotent stem cells (iPSC) offer the possibility to generate diverse disease-relevant cell types, from any genetic background with the use of cellular reprogramming and directed differentiation. This provides a powerful platform for diseas
Publikováno v:
European Journal of Biochemistry. 231:40-44
One of the cellular responses to hypotonic stress is a marked induction of a key regulatory enzyme in the polyamine biosynthetic pathway, i.e. ornithine decarboxylase (ODC). This increase in ODC activity appears to be a physiological response since t
Publikováno v:
European Journal of Biochemistry. 215:753-759
Ornithine decarboxylase catalyzes the first step in the biosynthesis of polyamines in mammalian cells. The enzyme is subject to various control mechanisms to maintain adequate intracellular levels of polyamines. Polyamines exert a strong feedback con
Publikováno v:
Assay and drug development technologies. 4(1)
The aim of the present study was to test the use of cryopreserved cells for human ether-ago- go (hERG) channel screening. A stable Chinese hamster ovary-K1 cell line expressing hERG channels was used in a non-radioactive Rb+ efflux assay for screenin
Publikováno v:
European journal of biochemistry. 214(3)
Cell proliferation is dependent on an adequate supply of the polyamines putrescine, spermidine and spermine. One of the key steps in the polyamine biosynthetic pathway is catalyzed by S-adenosylmethionine decarboxylase (AdoMetDC). In the present stud
Autor:
Lo Persson, Louise Stjernborg
Publikováno v:
Biochemical pharmacology. 45(5)
Aminoguanidine, an inhibitor of copper-containing amine oxidases, is often used in cell culture studies to prevent the oxidation of added polyamines or their derivatives by the amine oxidase present in bovine serum. However, in the present study, we
A potent irreversible inhibitor of S-adenosylmethionine (AdoMet) decarboxylase, S-(5'-adenosyl)-methylthio-2-aminooxyethane (AdoMeSaoe), was used to study the regulatory control of this key enzyme in the polyamine biosynthetic pathway. Treatment of L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9450d3707c6c4316a531fe1783036992
http://hdl.handle.net/2318/52009
http://hdl.handle.net/2318/52009
Publikováno v:
Assay & Drug Development Technologies; Feb2006, Vol. 4 Issue 1, p83-88, 6p
Publikováno v:
Progress in Polyamine Research ISBN: 9781468456394
Since the polyamines putrescine, spermidine and spermine are essential cellular components for growth and differentiation it is of no surprise that their synthesis is highly regulated. Disregarding arginase, which catalyzes the formation of ornithine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7b24cb1ab2630079017168fad624328
https://doi.org/10.1007/978-1-4684-5637-0_24
https://doi.org/10.1007/978-1-4684-5637-0_24