Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Louise Sivertsson"'
Autor:
Louise Sivertsson, Etienne P. A. Neve, Margareta Porsmyr Palmertz, Magnus Ingelman-Sundberg, Irene Edebert
Publikováno v:
Molecular Pharmacology. 83:659-670
We have previously shown that confluent growth of the human hepatoma cell line Huh7 substantially induces the CYP3A4 mRNA, protein, and activity levels. Here, the mechanisms behind were investigated, and a transcriptome analysis revealed significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a973116f6e7599fb27f9c3a0690a73
https://doi.org/10.1124/mol.112.082305
https://doi.org/10.1124/mol.112.082305
Autor:
Malin Darnell, Magnus Ingelman-Sundberg, Monica Ek, Etienne P. A. Neve, Irene Edebert, Louise Sivertsson
Publikováno v:
Drug Metabolism and Disposition. 38:995-1002
Drug-induced hepatotoxicity is an important cause for disapproval, limitations of use, or withdrawal of drugs, and there is a high need for reproducible in vitro systems that can predict such toxicity. In this study, we show that confluent growth of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7812a81c0f167fdcefdfadf0ffac5232
https://doi.org/10.1124/dmd.110.032367
https://doi.org/10.1124/dmd.110.032367
Autor:
Petter Björquist, Gustav Eriksson, Inger Johansson, Monica Ek, Nico Heins, Louise Sivertsson, Gabriella Brolén, Henrik Semb, Magnus Ingelman-Sundberg, Tommy B. Andersson
Publikováno v:
Journal of Biotechnology. 145:284-294
Human embryonic stem cells offer a potential unlimited supply for functional hepatocytes, since they can differentiate into hepatocyte-like cells displaying a characteristic hepatic morphology and expressing various hepatic markers. These cells could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367eee917c8f867241aa339185c3dc21
https://doi.org/10.1016/j.jbiotec.2009.11.007
https://doi.org/10.1016/j.jbiotec.2009.11.007
Publikováno v:
Toxicology in Vitro. 23:1387-1395
Drug-induced hepatotoxicity is a major reason for withdrawal of drugs from development as well as from the market. A major problem predicting hepatotoxicity is the lack of suitable predictive in vitro system. Drug-induced hepatotoxicity is usually as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08335cd3bf797547164d1f1fcc54168d
https://doi.org/10.1016/j.tiv.2009.07.026
https://doi.org/10.1016/j.tiv.2009.07.026
Drug-induced liver injury is a serious and frequently occurring adverse drug reaction in the clinics and is hard to predict during preclinical studies. Today, primary hepatocytes are the most frequently used cell model for drug discovery and predicti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30681abf4484e9ff82372026f8722c43
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-8402
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-8402
Autor:
Tommy B. Andersson, Ylva Edling, Margareta Porsmyr-Palmertz, Louise Sivertsson, Magnus Ingelman-Sundberg
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 22(6)
There is a lack of suitable human in vitro systems which can predict drug hepatotoxicity that in many cases involves inflammatory responses mediated by macrophages. In the present investigation we used an in vitro model based on human THP-1 cells to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a78ddba284950c734687a40da41f50
https://pubmed.ncbi.nlm.nih.gov/18640260
https://pubmed.ncbi.nlm.nih.gov/18640260