Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Louise Showe"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The most common approaches to discovering genes associated with specific diseases are based on machine learning and use a variety of feature selection techniques to identify significant genes that can serve as biomarkers for a given disease.
Externí odkaz:
https://doaj.org/article/7e0d99f912504d01965405b91206c9e5
Autor:
Anjana Yadav, Andrew Kossenkov, Louise Showe, Sarah Ratcliffe, Grace Choi, Luis Montaner, Pablo Tebas, Pamela Shaw, Ronald Collman
Publikováno v:
Pathogens and Immunity, Vol 6, Iss 2 (2021)
Background: Many people living with HIV have persistent monocyte activation despite viral suppression by antiretroviral therapy (ART), which contributes to non-AIDS complications including neurocognitive and other disorders. Statins have immunomodula
Externí odkaz:
https://doaj.org/article/c55f3834fb7b470cb7ada30aef9d007a
Autor:
R Jason Lamontagne, Samantha S Soldan, Chenhe Su, Andreas Wiedmer, Kyoung Jae Won, Fang Lu, Aaron R Goldman, Jayamanna Wickramasinghe, Hsin-Yao Tang, David W Speicher, Louise Showe, Andrew V Kossenkov, Paul M Lieberman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009208 (2021)
Epstein-Barr virus (EBV) immortalizes resting B-lymphocytes through a highly orchestrated reprogramming of host chromatin structure, transcription and metabolism. Here, we use a multi-omics-based approach to investigate these underlying mechanisms. A
Externí odkaz:
https://doaj.org/article/48776a669bd044a5a1887f85a9a8d95d
Autor:
Bethsebah Gekonge, Malavika S Giri, Andrew V Kossenkov, Michael Nebozyhn, Malik Yousef, Karam Mounzer, Louise Showe, Luis J Montaner
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41153 (2012)
Elevated TLR expression/signalling in monocyte/macrophages has been shown to mediate systemic immune activation, a hallmark of progressive HIV-1 infection. Here we show, via differential gene expression comparisons, the presence of a constitutive in
Externí odkaz:
https://doaj.org/article/cfdca653f8dc4778a67c32ba4826a3f2
Autor:
Qihong Huang, Lin Zhang, Louise Showe, Hua Xu, Jinchun Yan, Qin Liu, Kathy Q. Cai, Andrew V. Kossenkov, Anping Li, Kiranmai Gumireddy
Supplementary Figure 1. Expression of Id1 and Id2 was determined by qRT-PCR in MCF7 cells expressing a vector control, or Id1, or Id2. Supplemenatary Figure 2. Id1 expression in human primary breast cancer and metastatic samples, and MCF7 cells expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d1163c077529e7dda21813b389cc12
https://doi.org/10.1158/1541-7786.22512084.v1
https://doi.org/10.1158/1541-7786.22512084.v1
Autor:
Qihong Huang, Lin Zhang, Louise Showe, Hua Xu, Jinchun Yan, Qin Liu, Kathy Q. Cai, Andrew V. Kossenkov, Anping Li, Kiranmai Gumireddy
Metastasis is a major factor responsible for mortality in patients with breast cancer. Inhibitor of DNA binding 1 (Id1) has been shown to play an important role in cell differentiation, tumor angiogenesis, cell invasion, and metastasis. Despite the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266e48e8c657f18601521a215f6a1d69
https://doi.org/10.1158/1541-7786.c.6540123.v1
https://doi.org/10.1158/1541-7786.c.6540123.v1
Autor:
Joseph Kelich, Tomas Aramburu, Joanne J. van der Vis, Louise Showe, Andrew Kossenkov, Jasper van der Smagt, Maarten Massink, Angela Schoemaker, Eric Hennekam, Marcel Veltkamp, Coline H.M. van Moorsel, Emmanuel Skordalakes
Publikováno v:
The Journal of experimental medicine. 219(5)
Exonic sequencing identified a family with idiopathic pulmonary fibrosis (IPF) containing a previously unreported heterozygous mutation in POT1 p.(L259S). The family displays short telomeres and genetic anticipation. We found that POT1(L259S) is defe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9ef2aea75e026cba0e2dce60029d04
https://pubmed.ncbi.nlm.nih.gov/35420632
https://pubmed.ncbi.nlm.nih.gov/35420632
Autor:
Louise Showe, Harold W. Avery, Sift Desk, Barbara A. Bell, Richard B. Huneke, Amit Basu, Kimberly D. Magrini, Shankar Addya, and James R. Spotila
Publikováno v:
SDRP Journal of Earth Sciences & Environmental Studies. 4:516-533
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48736e070ac4780ede10e8ad500291af
https://doi.org/10.25177/jeses.4.1.ra.438
https://doi.org/10.25177/jeses.4.1.ra.438
Autor:
Daniel Lindsay, Cris S. Constantinescu, Kiyokazu Kawabe, Angela J. Fahey, Manjit Braitch, Louise Showe
Publikováno v:
Immunobiology. 217(1)
Interleukin (IL)-12 is an important pro-inflammatory cytokine that has been shown to play a role in T cell survival, at least in part by activating the PI3K/Akt pathway. Glucocorticoid modulatory element binding protein (GMEB)1 and 2 are closely rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d20f7bc928856bae40dcaa2ad9a0156
https://pubmed.ncbi.nlm.nih.gov/21840619
https://pubmed.ncbi.nlm.nih.gov/21840619
Autor:
Hildegund C. J. Ertl, Susanna Pasquini, Zhenning He, Hongying Deng, Louise Showe, Wynetta Giles-Davis, Yijie Wang, InSug O, Hilary Marston, Magdalena Blaszczyk-Thurin, Zhiquan Xiang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d39bfe87ff4293d1430abc1926d9c6a
https://doi.org/10.1385/1-59259-688-6:251
https://doi.org/10.1385/1-59259-688-6:251