A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation

Autor: Iris Mair, Stephanie E. J. Zandee, Iqbal S. Toor, Louise Saul, Rhoanne C. McPherson, Melanie D. Leech, Danielle J. Smyth, Richard A. O’Connor, Neil C. Henderson, Stephen M. Anderton

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Several inflammatory diseases including multiple sclerosis and inflammatory bowel disease have been associated with dysfunctional and/or reduced numbers of Foxp3+ regulatory T cells (Treg). While numerous mechanisms of action have been discovered by

Externí odkaz: https://doaj.org/article/71a9e22f44f044f6b76a20174ef74fc8

Supplementary Figure S4 from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Autor: Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs

Evaluation of FRalpha expression by tumor cell lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38db7cb9edccc92a72b16204c6c84d78
https://doi.org/10.1158/0008-5472.22416014.v1

Data from Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Autor: Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs

IgE antibodies are key mediators of antiparasitic immune responses, but their potential for cancer treatment via antibody-dependent cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen–specific IgEs were reported to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816bd38045ed7ffde480f7e6dc0d11ea
https://doi.org/10.1158/0008-5472.c.6509447.v1

AllergoOncology - the impact of allergy in oncology: EAACI position paper

Autor: Rodolfo Bianchini, Manuel L. Penichet, Luca Vangelista, Elisa Agnese Nigro, Josef Singer, Eva Untersmayr, Heather J. Bax, Antonio G. Siccardi, Michelle C. Turner, T. R. Daniels-Wells, Francesca Levi-Schaffer, Mariana Castells, Diana Mechtcheriakova, Panagiotis Karagiannis, Christopher Corrigan, Frank A. Redegeld, S. Gatault, Debra H. Josephs, David Dombrowicz, Louise Saul, Erika Jensen-Jarolim, Sophia N. Karagiannis, Y. Mekori, Felicitas Mungenast, James Spicer, Judit Fazekas, Edda Fiebiger, Hannah J. Gould, Anastasia Meshcheryakova, Monique Capron, Jozef Janda, Edzard Spillner

Publikováno v: Jensen-Jarolim, E, Bax, H J, Bianchini, R, Capron, M, Corrigan, C, Castells, M, Dombrowicz, D, Daniels-Wells, T R, Fazekas, J, Fiebiger, E, Gatault, S, Gould, H J, Janda, J, Josephs, D H, Karagiannis, P, Levi-Schaffer, F, Meshcheryakova, A, Mechtcheriakova, D, Mekori, Y, Mungenast, F, Nigro, E A, Penichet, M L, Redegeld, F, Saul, L, Singer, J, Spicer, J F, Siccardi, A G, Spillner, E, Turner, M C, Untersmayr, E, Vangelista, L & Karagiannis, S N 2017, ' AllergoOncology-the impact of allergy in oncology : EAACI position paper ', Allergy, vol. 72, no. 6, pp. 866-887 . https://doi.org/10.1111/all.13119
Jensen-Jarolim, E, Bax, HJ, Bianchini, R, Capron, M, Corrigan, C, Castells, M, Dombrovicz, D, Daniels-Wells, HR, Fazekas, J, Fiebiger, E, Gatault, S, Gould, H, Janda, J, Josephs, DH, Karagiannis, P, Levi-Schaffer, F, Meshcheryakova, A, Mechtcheriakova, D, Mekori, Y, Mungenast, F, Nigro, EA, Penichet, M F, Redegeld, F, Saul, L, Singer, J, Spicer, JF, Siccardi, AG, Spillner, E, Turner, MC, Untersmayr, E, Vangelista, L & Karagiannis, S N 2017, ' AllergoOncology-the Impact of Allergy in Oncology. EAACI Position Paper. ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 72, no. 6, pp. 866-887 . https://doi.org/10.1111/all.13119

Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf18818459054d0000c9baa1c732113
https://doi.org/10.1111/all.13119

IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin

Autor: Louise Saul, Kristina M. Ilieva, Heather J. Bax, Panagiotis Karagiannis, Isabel Correa, Irene Rodriguez-Hernandez, Debra H. Josephs, Isabella Tosi, Isioma U. Egbuniwe, Sara Lombardi, Silvia Crescioli, Carl Hobbs, Federica Villanova, Anthony Cheung, Jenny L. C. Geh, Ciaran Healy, Mark Harries, Victoria Sanz-Moreno, David J. Fear, James F. Spicer, Katie E. Lacy, Frank O. Nestle, Sophia N. Karagiannis

Publikováno v: Saul, L, Ilieva, K M, Bax, H J, Karagiannis, P, Correa, I, Rodriguez-Hernandez, I, Josephs, D H, Tosi, I, Egbuniwe, I U, Lombardi, S, Crescioli, S, Hobbs, C, Villanova, F, Cheung, A, Geh, J L C, Healy, C, Harries, M, Sanz-Moreno, V, Fear, D J, Spicer, J F, Lacy, K E, Nestle, F O & Karagiannis, S N 2016, ' IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin ', Scientific Reports, vol. 6, 29736 . https://doi.org/10.1038/srep29736
Scientific Reports

B cells participate in immune surveillance in human circulation and tissues, including tumors such as melanoma. By contrast, the role of humoral responses in cutaneous immunity is underappreciated. We report circulating skin-homing CD22+CLA+B cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4e5f6974dba43b7bcd23d159cf9ff10c
https://kclpure.kcl.ac.uk/ws/files/54701902/srep29736.pdf