Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Louise S Matheson"'
Autor:
David J Turner, Alexander Saveliev, Fiamma Salerno, Louise S Matheson, Michael Screen, Hannah Lawson, David Wotherspoon, Kamil R Kranc, Martin Turner
Publikováno v:
eLife, Vol 11 (2022)
To identify roles of RNA binding proteins (RBPs) in the differentiation or survival of antibody secreting plasma cells we performed a CRISPR/Cas9 knockout screen of 1213 mouse RBPs for their ability to affect proliferation and/or survival, and the ab
Externí odkaz:
https://doaj.org/article/82d0b3c9007147978c12bb01398d56b3
Autor:
Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner
Publikováno v:
eLife, Vol 9 (2020)
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensat
Externí odkaz:
https://doaj.org/article/b68b2bc2ff684844afe3e2ee6dd99ca4
Autor:
Fiamma Salerno, Andrew J. M. Howden, Louise S. Matheson, Özge Gizlenci, Michael Screen, Holger Lingel, Monika C. Brunner-Weinzierl, Martin Turner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. Here we use label-free proteomics to quantify the proteome of B c
Externí odkaz:
https://doaj.org/article/a73a6dd20eda46d58f1c7c4fa5d6a06d
Autor:
Louise S. Matheson, Georg Petkau, Beatriz Sáenz-Narciso, Vanessa D’Angeli, Jessica McHugh, Rebecca Newman, Haydn Munford, James West, Krishnendu Chakraborty, Jennie Roberts, Sebastian Łukasiak, Manuel D. Díaz-Muñoz, Sarah E. Bell, Sarah Dimeloe, Martin Turner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-24 (2022)
Abstract The ZFP36 family of RNA-binding proteins acts post-transcriptionally to repress translation and promote RNA decay. Studies of genes and pathways regulated by the ZFP36 family in CD4+ T cells have focussed largely on cytokines, but their impa
Externí odkaz:
https://doaj.org/article/502be5987af14790b105142b3363eb12
Autor:
Olga Mielczarek, Carolyn H. Rogers, Yinxiu Zhan, Louise S. Matheson, Michael J.T. Stubbington, Stefan Schoenfelder, Daniel J. Bolland, Biola M. Javierre, Steven W. Wingett, Csilla Várnai, Anne Segonds-Pichon, Simon J. Conn, Felix Krueger, Simon Andrews, Peter Fraser, Luca Giorgetti, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113074- (2023)
Summary: To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (VH), diversity (DH), and joining (JH)
Externí odkaz:
https://doaj.org/article/125cbc8ecfba40ce99ab9245a423021d
Autor:
Hashem Koohy, Daniel J. Bolland, Louise S. Matheson, Stefan Schoenfelder, Claudia Stellato, Andrew Dimond, Csilla Várnai, Peter Chovanec, Tamara Chessa, Jeremy Denizot, Raquel Manzano Garcia, Steven W. Wingett, Paula Freire-Pritchett, Takashi Nagano, Phillip Hawkins, Len Stephens, Sarah Elderkin, Mikhail Spivakov, Peter Fraser, Anne E. Corcoran, Patrick D. Varga-Weisz
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-24 (2018)
Abstract Background Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression and chromatin f
Externí odkaz:
https://doaj.org/article/6176506a0b014dd1a2e2a5beb2a2e029
Autor:
Rena Levin-Klein, Shira Fraenkel, Michal Lichtenstein, Louise S. Matheson, Osnat Bartok, Yuval Nevo, Sebastian Kadener, Anne E. Corcoran, Howard Cedar, Yehudit Bergman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochas
Externí odkaz:
https://doaj.org/article/a60058be570b46449a317fcb6741376b
Autor:
Vanessa D’Angeli, Elisa Monzón-Casanova, Louise S. Matheson, Özge Gizlenci, Georg Petkau, Clare Gooding, Rebecca V. Berrens, Christopher W. J. Smith, Martin Turner
Publikováno v:
European Journal of Immunology. 52:1058-1068
The RNA-binding protein polypyrimidine tract binding protein 1 (PTBP1) has been found to have roles in CD4 T-cell activation, but its function in CD8 T cells remains untested. We show it is dispensable for the development of naïve mouse CD8 T cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6177636ea190a0e34eb80d74763e8212
https://doi.org/10.1002/eji.202149781
https://doi.org/10.1002/eji.202149781
Autor:
Daniel J. Bolland, Hashem Koohy, Andrew L. Wood, Louise S. Matheson, Felix Krueger, Michael J.T. Stubbington, Amanda Baizan-Edge, Peter Chovanec, Bryony A. Stubbs, Kristina Tabbada, Simon R. Andrews, Mikhail Spivakov, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2475-2487 (2016)
Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage. We have developed VDJ
Externí odkaz:
https://doaj.org/article/2754b12283b14484b5441338b9c3ac7a
Autor:
Fiamma Salerno, Andrew J. M. Howden, Louise S. Matheson, Özge Gizlenci, Michael Screen, Holger Lingel, Monika C. Brunner-Weinzierl, Martin Turner
Publikováno v:
BioRxiv
bioRxiv
bioRxiv
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. We used label-free mass spectrometry to quantify the proteome of B cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aad07e889cc855d795801cd51a2549e
https://doi.org/10.1101/2022.12.22.521580
https://doi.org/10.1101/2022.12.22.521580
