Výsledky vyhledávání - "Louise S Dalbøge"

Akademický článek

Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons

Publikováno v: Molecular Metabolism, Vol 26, Iss , Pp 18-29 (2019)

Objective: Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophren

Externí odkaz: https://doaj.org/article/2fb89f157ba64298a2342ca376aaca21

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Akademický článek

Nephroprotective Effects of Semaglutide as Mono- and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease

Autor: Louise S. Dalbøge, Michael Christensen, Martin Rønn Madsen, Thomas Secher, Nicole Endlich, Vedran Drenic’, Alba Manresa-Arraut, Henrik H. Hansen, Ida Rune, Lisbeth N. Fink, Mette V. Østergaard

Publikováno v: Biomedicines, Vol 10, Iss 7, p 1661 (2022)

Background: Obesity, hyperglycemia and hypertension are critical risk factors for development of diabetic kidney disease (DKD). Emerging evidence suggests that glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular and renal outcom

Externí odkaz: https://doaj.org/article/c0feffdb62e2458593f267886e8f3e7e

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MO069: Therapeutic Effects of Semaglutide as Mono and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease

Autor: Michael Christensen, Louise S Dalbøge, Thomas Secher, Casper Gravesen Salinas, Rune Ida, Henrik Björk Hansen, Lisbeth N Fink, Mette Viberg Østergaard

Publikováno v: Nephrology Dialysis Transplantation. 37

BACKGROUND AND AIMS Obesity, hyperglycemia and hypertension are critical risk factors for the onset and progression of diabetic kidney disease (DKD). Emerging evidence suggests that sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9efc486a1a74a5fc7759bc4fc8153c1b
https://doi.org/10.1093/ndt/gfac063.021

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Akademický článek

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents.

Autor: Louise S Dalbøge, Philip J Pedersen, Gitte Hansen, Katrine Fabricius, Henrik B Hansen, Jacob Jelsing, Niels Vrang

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135634 (2015)

Unlike rats and mice, hamsters develop hypercholesterolemia, and hypertriglyceridemia when fed a cholesterol-rich diet. Because hyperlipidemia is a hallmark of human obesity, we aimed to develop and characterize a novel diet-induced obesity (DIO) and

Externí odkaz: https://doaj.org/article/c71f9205a59d47268432a13b2c285b66

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Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 26, Iss, Pp 18-29 (2019)

Objective Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophreni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ad358a49d1b18695f17a8716e6a105
https://doi.org/10.1016/j.molmet.2019.06.001

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Akademický článek

Characterisation of age-dependent beta cell dynamics in the male db/db mice.

Autor: Louise S Dalbøge, Dorthe L C Almholt, Trine S R Neerup, Efstathios Vassiliadis, Niels Vrang, Lars Pedersen, Keld Fosgerau, Jacob Jelsing

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82813 (2013)

AIM: To characterise changes in pancreatic beta cell mass during the development of diabetes in untreated male C57BLKS/J db/db mice. METHODS: Blood samples were collected from a total of 72 untreated male db/db mice aged 5, 6, 8, 10, 12, 14, 18, 24 a

Externí odkaz: https://doaj.org/article/3390669c0ceb41baae723447f2898ee6

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Akademický článek

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats.

Autor: Carl Frederik Hansen, Marco Bueter, Nadine Theis, Thomas Lutz, Sarah Paulsen, Louise S Dalbøge, Niels Vrang, Jacob Jelsing

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65696 (2013)

BACKGROUND AND AIMS: Roux-en-Y gastric bypass (RYGB) leads to a rapid remission of type 2 diabetes mellitus (T2DM), but the underlying mode of action remains incompletely understood. L-cell derived gut hormones such as glucagon-like peptide-1 (GLP-1)

Externí odkaz: https://doaj.org/article/62bf369347f546f49a763143c225bee0

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Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human primates

Autor: Burak Kutlu, Mette Guldbrandt, Christina A. Sanford, Ayesha Misquith, Paul Kievit, Kevin L. Grove, Birgitte Andersen, Sara A. Murray, Karalee Baquero, Louise S. Dalbøge, Thomas H. Meek, Aaron J. Mercer

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports

Fibroblast growth factor 21 (FGF21) induces weight loss in mouse, monkey, and human studies. In mice, FGF21 is thought to cause weight loss by stimulating thermogenesis, but whether FGF21 increases energy expenditure (EE) in primates is unclear. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69870d4873a7f073cb01baa1ddc43d37
https://doi.org/10.1038/s41598-020-64170-6

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GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Autor: Søren Blok van Witteloostuijn, Jacob Jelsing, Søren L. Pedersen, Grethe V. Jensen, Knud J. Jensen, Niels Vrang, Søren Roi Midtgaard, Louise S. Dalbøge, Gitte Hansen

Publikováno v: Journal of Peptide Science. 23:845-854

Bariatric surgery is currently the most effective treatment of obesity, which has spurred an interest in developing pharmaceutical mimetics. It is thought that the marked body weight-lowering effects of bariatric surgery involve stimulated secretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff9ba21c2bd13e620abd499de65966f5
https://doi.org/10.1002/psc.3048

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Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Autor: Louise S. Dalbøge, Jens J. Holst, Hazem Hassan, Brynjulf Mortensen, Jakob Hendel, Steen Seier Poulsen, Jens Pedersen, Tina Jorsal, Tina Vilsbøll, Nicolai Rhee, Filip K. Knop, Jacob Jelsing, Sara L. Jepsen, Camilla D. Wahlgren, Peter Vilmann

Publikováno v: Diabetologia. 61:284-294

Enteroendocrine K and L cells are pivotal in regulating appetite and glucose homeostasis. Knowledge of their distribution in humans is sparse and it is unknown whether alterations occur in type 2 diabetes. We aimed to evaluate the distribution of ent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400d54ba24b9108ca2aa3b8f9c587a51
https://doi.org/10.1007/s00125-017-4450-9

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