Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Louise R. Whittell"'
Autor:
Alexander P Martyn, Fay E. Dawes, Aaron J. Oakley, Nicholas E. Dixon, Jennifer L. Beck, Amy E. McGrath, Michael J. Kelso, Louise R. Whittell
Publikováno v:
Journal of structural biology. 204(3)
Bacterial sliding clamps bind to DNA and act as protein-protein interaction hubs for several proteins involved in DNA replication and repair. The partner proteins all bind to a common pocket on sliding clamps via conserved linear peptide sequence mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e420cd14dcad18736a1f76c6d17241
https://pubmed.ncbi.nlm.nih.gov/31097372
https://pubmed.ncbi.nlm.nih.gov/31097372
Autor:
Aaron J. Oakley, Nehad S. El Salamouni, Louise R. Whittell, Fay E. Dawes, Amy E. McGrath, Jennifer L. Beck, Alexander P Martyn, Michael J. Kelso, Nicholas E. Dixon
Publikováno v:
Journal of Structural Biology. 207:234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddae05f7b8ba6c7b8b04eebb95968ff1
https://doi.org/10.1016/j.jsb.2019.05.003
https://doi.org/10.1016/j.jsb.2019.05.003
Autor:
Aaron J. Oakley, Cong Ma, Louise R. Whittell, Michael J. Kelso, Peter J. Lewis, Nicholas E. Dixon, Yao Wang, Jennifer L. Beck, Slobodan Jergic, Zhou Yin
Publikováno v:
Journal of medicinal chemistry. 58(11)
The bacterial DNA replication machinery presents new targets for the development of antibiotics acting via novel mechanisms. One such target is the protein–protein interaction between the DNA sliding clamp and the conserved peptide linear motifs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfd6de832e5c90591d3dbd162e472c5
https://pubmed.ncbi.nlm.nih.gov/25970224
https://pubmed.ncbi.nlm.nih.gov/25970224
Autor:
Aaron J. Oakley, Elizabeth J. Harry, Yao Wang, Michael J. Kelso, Louise R. Whittell, Nicholas E. Dixon, Slobodan Jergic, Jennifer L. Beck, Michael Liu, Zhou Yin
Publikováno v:
Journal of medicinal chemistry. 57(6)
The bacterial sliding clamp (SC), also known as the DNA polymerase III β subunit, is an emerging antibacterial target that plays a central role in DNA replication, serving as a protein-protein interaction hub with a common binding pocket to recogniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fcc499fd4c49790824d92874c6ae1d
https://pubmed.ncbi.nlm.nih.gov/24592885
https://pubmed.ncbi.nlm.nih.gov/24592885
Autor:
Louise R. Whittell, Timothy M. E. Davis, Paul E. Murray, Kevin T. Batty, Simon A. Fox, Erin M. Bolitho, Rina P. M. Wong
Publikováno v:
Bioorganicmedicinal chemistry. 19(24)
A series of mono- and di-substituted analogues of isocryptolepine have been synthesized and evaluated for in vitro antimalarial activity against chloroquine sensitive (3D7) and resistant (W2mef) Plasmodium falciparum and for cytotoxicity (3T3 cells).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c5254efb10a892daf05741fd40fcb5
https://pubmed.ncbi.nlm.nih.gov/22055713
https://pubmed.ncbi.nlm.nih.gov/22055713
Autor:
Zhou Yin, Louise R. Whittell, Yao Wang, Slobodan Jergic, Cong Ma, Peter J. Lewis, NicholasE. Dixon, Jennifer L. Beck, Michael J. Kelso, Aaron J. Oakley
Publikováno v:
Journal of Medicinal Chemistry; Jun2015, Vol. 58 Issue 11, p4693-4702, 10p
Autor:
Nicholas E. Dixon, Aaron J. Oakley, Michael J. Kelso, Elizabeth J. Harry, Yao Wang, Slobodan Jergic, Zhou Yin, Louise R. Whittell, Michael Liu, Jennifer L. Beck
Publikováno v:
Chemistry & Biology. (4):481-487
Evidence suggests that some nonsteroidal anti-inflammatory drugs (NSAIDs) possess antibacterial properties with an unknown mechanism. We describe the in vitro antibacterial properties of the NSAIDs carprofen, bromfenac, and vedaprofen, and show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a487f6a4fa2cd5372597266e7309c95e